This Week In Medicine

NEJM 3 26 26 Dengue Suppression by Male Wolbachia-Infected Mosquitoes.

Sat, 28 Mar 2026 23:00:02 +0000

This research study explores a biological method for controlling dengue fever in Singapore by releasing specially infected male mosquitoes into the environment. These males carry a bacterium called Wolbachia, which ensures that any offspring produced from mating with wild females are nonviable, effectively crashing the local mosquito population. Over a two-year period, the experiment successfully demonstrated that areas treated with these releases saw a dramatic reduction in wild mosquito abundance compared to control zones. Most importantly, the intervention resulted in a 71 to 72% decrease in dengue infections among residents, proving that sterile insect technology is a highly effective tool for public health protection

NEJM 3 26 26 Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years

Sat, 28 Mar 2026 22:19:18 +0000

This study investigates whether proactive medical intervention or watchful waiting provides better long-term outcomes for patients with severe aortic stenosis who do not yet show symptoms. Researchers compared a strategy of early surgical intervention against traditional conservative care by monitoring patient health outcomes over a ten-year period. The data revealed that patients who underwent surgery sooner experienced a significantly lower risk of cardiovascular death and a higher overall survival rate compared to those who delayed treatment. Ultimately, the text demonstrates that preemptive surgery offers a superior survival benefit, challenging the conventional practice of waiting for symptoms to appear before operating.

NEJM 3 26 26 Atezolizumab plus FOLFOX for Stage III Mismatch Repair–Deficient Colon Cancer

Sat, 28 Mar 2026 22:12:06 +0000

his clinical study investigates whether adding the immunotherapy drug atezolizumab to standard chemotherapy significantly benefits patients recovering from high-risk, stage III colon cancer with specific genetic deficiencies. Researchers compared a traditional drug cocktail against a combination treatment followed by extended immunotherapy to see if it could better prevent cancer recurrence. The results demonstrated that this dual approach markedly improved disease-free survival rates over three years, despite a noted increase in side effects. Ultimately, the text highlights a major advancement in personalized oncology, suggesting that targeting a tumor's specific molecular profile can lead to superior long-term outcomes

Lancet March 2026 Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study

Tue, 17 Mar 2026 20:47:38 +0000

This international study investigates the clinical landscape for immunocompromised individuals suffering from acute respiratory failure, a primary driver of intensive care admissions. By analyzing nearly ten thousand patients across twenty-six countries, researchers identified that infectionand malignancies are the most common underlying triggers, resulting in a high thirty-day mortality rate of over 47%. The findings highlight critical prognostic factors, such as age, frailty, and the specific cause of lung distress, while noting that certain treatments like high-flow nasal oxygenmay offer protective benefits. Ultimately, this research provides a vital framework for clinicians to make informed management decisions and improve survival outcomes for this highly vulnerable population.

Lancet March 2026 The effectiveness of HPV vaccination against invasive cervical cancer and related precancerous lesions: a multinational target trial emulation study

Tue, 17 Mar 2026 20:38:27 +0000

By analyzing extensive healthcare data from the United Kingdom, Spain, and Norway, this study evaluates how well HPV vaccination programs protect young women against serious cervical disease over a fifteen-year period. Researchers utilized a target trial emulation to compare health outcomes between vaccinated and unvaccinated individuals, specifically focusing on the prevention of high-grade precancerous lesions and surgical interventions. The findings demonstrate a significant reduction in these risks, confirming that the vaccines remain a highly effective preventative measure in real-world clinical settings. While there were too few cases to draw definitive conclusions about invasive cancer, the results strongly reinforce the long-term public health benefits of early immunization.

NEJM March 12 2026 Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia

Thu, 12 Mar 2026 21:54:16 +0000

This study evaluates whether time-limited drug combinations are as effective as lifelong daily medication for patients newly diagnosed with chronic lymphocytic leukemia. By comparing three specific drug regimens over a three-year period, researchers found that the shorter, fixed-duration treatments performed just as well at keeping the cancer from progressing as the standard continuous therapy. Notably, the fixed-duration groups showed significantly higher rates of undetectable residual disease, suggesting that intensive, brief therapy can achieve deep remission. Ultimately, the trial proves that patients can achieve equivalent survival outcomes without the need for indefinite treatment, potentially reducing long-term side effects and improving quality of life.

NEJM March 12 2026 Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia

Thu, 12 Mar 2026 21:49:57 +0000

This study investigates the effectiveness of the drug romiplostim in managing a frequent cancer treatment complication where chemotherapy causes a dangerous drop in blood platelets. By comparing the drug against a placebo in patients with gastrointestinal cancers, researchers aimed to see if the treatment could prevent dosage modifications like delays or reductions. The results demonstrated that patients receiving the drug were significantly more likely to maintain their intended chemotherapy schedule, showing a success rate more than double that of the control group. Ultimately, the findings suggest that this therapy is an efficacious solution for stabilizing platelet levels, allowing for more consistent and potentially more effective cancer treatment without introducing severe new safety risks.

NEJM March 12 2026 Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism

Thu, 12 Mar 2026 21:40:11 +0000

This clinical study investigates the safety profiles of two common blood thinners by comparing their potential to cause harmful side effects during the treatment of blood clots. Researchers conducted a large-scale international trial to determine whether patients using apixaban or rivaroxaban faced a higher danger of clinically relevant bleeding over a three-month period. The findings revealed that those treated with apixaban experienced significantly lower bleeding risks, with less than half the incident rate of the rivaroxaban group. Ultimately, the trial provides critical evidence that apixaban serves as a safer anticoagulation alternative for individuals managing acute venous thromboembolism.

JAMA Pediatrics March 2026 Screen Use at Bedtime and Sleep Duration and Quality Among Youths

Thu, 05 Mar 2026 16:06:44 +0000

This study utilized objective video monitoring and wearable sensors to move beyond unreliable self-reporting when investigating how adolescent technology use affects rest. The researchers discovered that while general screen time in the two hours before bed had little impact on sleep, device use while physically in bed significantly reduced total sleep time. The findings highlight that interactive activities, such as gaming or multitasking, are far more disruptive to sleep health than passive consumption. Consequently, the authors suggest that traditional advice to avoid all screens before bed is outdated, arguing instead that interventions should focus specifically on restricting device engagement after getting into bed.

NEJM March 5 2026 Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction

Thu, 05 Mar 2026 14:26:07 +0000

This study investigated whether the timing and method of treating secondary arterial blockages in heart attack patients affects their long-term recovery. Researchers compared two distinct strategies: performing immediate corrective surgery guided by internal pressure measurements versus postponing treatment until after an external cardiac stress MRI. The findings revealed that performing the procedure right away offered no significant clinical advantage over waiting up to six weeks for further imaging. Ultimately, both approaches resulted in comparable rates of major health complications like heart failure or recurrent attacks over a three-year period.

NEJM March 5 2026 Finerenone in Type 1 Diabetes and Chronic Kidney Disease

Thu, 05 Mar 2026 13:43:41 +0000

This clinical study investigates whether the drug finerenone can help protect the kidneys of adults living with type 1 diabetes, a population for whom the medication's effects were previously uncertain. By tracking the urinary albumin-to-creatinine ratio, researchers discovered that those taking the drug experienced a significant reduction in protein leakage compared to those on a placebo. While the treatment proved effective at lowering this key marker of kidney damage, it also carried a higher risk of hyperkalemia, or elevated potassium levels. Ultimately, the trial demonstrates that this nonsteroidal therapy offers a promising new intervention for managing chronic kidney disease in patients with type 1 diabetes

JAMA February 2026 Coffee and Tea Intake, Dementia Risk, and Cognitive Function

Fri, 27 Feb 2026 23:25:18 +0000

This extensive longitudinal study tracked over 130,000 individuals for more than four decades to clarify how different hot beverages impact long-term brain health. The researchers discovered that regular consumption of caffeinated coffee and tea is linked to a statistically significant reduction in dementia risk and better preservation of mental clarity. Interestingly, these protective benefits were most evident at moderate intake levels, specifically around two to three cups of coffee or one to two cups of tea daily. Conversely, the data revealed that decaffeinated coffee offered no such advantages, suggesting that caffeine or specific compounds associated with it play a vital role in maintaining cognitive function as we age.

JAMA February 2026 Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation

Fri, 27 Feb 2026 23:22:10 +0000

This clinical study investigated the most effective way to manage multiple brain metastases by comparing highly targeted stereotactic radiationagainst a broader approach that treats the entire brain while protecting the hippocampus. By measuring how cancer treatments affect a patient's symptom severity and daily functioning, researchers sought to identify which method preserves a higher quality of life for those with five to twenty tumors. The results demonstrated that the localized approach significantly outperformed the whole-brain method, leading to a meaningful reduction in patient-reported distress. Ultimately, the findings suggest that precision-focused radiation should be the preferred choice for maintaining the well-being of patients facing extensive brain involvement.

JAMA February 2026 Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging

Fri, 27 Feb 2026 22:53:37 +0000

This global study examines the ionizing radiation exposure that patients experience during common medical imaging procedures used to diagnose heart disease. By analyzing data from over 100 countries, the researchers discovered significant disparities in dosage depending on the specific type of technology used and the geographic location of the patient. A major finding is that individuals in low-income regions are often exposed to much higher levels of radiation than those in wealthier nations, particularly during coronary CT scans. Ultimately, the text highlights a pressing need for standardized protocols and modern equipment to ensure that diagnostic testing is safer and more equitable for patients worldwide.

NEJM February 2026 Tecovirimat for the Treatment of Mpox

Thu, 26 Feb 2026 14:59:46 +0000

This clinical study investigated whether the drug tecovirimat, originally approved for smallpox based on animal data, effectively treats human clade II mpox. By comparing a group receiving the medication against a group receiving a placebo, researchers meticulously tracked the time required for skin lesions to heal and for pain to subside. Ultimately, the trial revealed that tecovirimat provided no significant benefit over the placebo in accelerating recovery or reducing viral presence. These findings suggest that while the drug remains a known intervention for related viruses, its clinical efficacy for this specific strain of mpox is not supported by the data.

NEJM February 2026 Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges

Thu, 26 Feb 2026 14:45:24 +0000

This study investigates whether a long-acting injectable treatment is more effective than traditional daily pills for HIV patients who struggle with medication adherence. Researchers compared a monthly regimen of cabotegravir and rilpivirine against standard oral therapy in a group of participants who previously had difficulty maintaining low viral levels. The trial was halted early because the injectable method proved significantly superior, resulting in a much lower rate of treatment failure compared to the oral alternative. Ultimately, the findings suggest that moving away from daily pills toward periodic injections can provide a more reliable and successful health outcome for high-risk populations facing consistency challenges.

NEJM February 2026 Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer

Thu, 26 Feb 2026 14:43:55 +0000

This clinical study evaluates a promising medical advancement for patients with HER2-positive breast cancer who still have signs of the disease following their initial surgery and treatment. Researchers compared the effectiveness of a newer drug, T-DXd, against the long-standing standard of care, T-DM1, to see which better prevented the cancer from returning. The results were striking, showing that patients receiving T-DXd had a significantly higher survival rate without the disease recurring compared to those on the traditional therapy. While the new treatment demonstrated superior protection against relapse, it also introduced specific side effects, most notably gastrointestinal issues and a serious inflammatory lung condition that requires careful clinical monitoring. Ultimately, the study suggests a shift in the standard treatment protocol for high-risk patients, offering a more effective path toward long-term recovery.

Lancet February 2026 Serotype-specific pneumococcal invasiveness: a global meta-analysis of paired estimates of disease incidence and carriage prevalence B

Tue, 24 Feb 2026 19:49:46 +0000

Source guide This meta-analysis explores the invasiveness of various pneumococcal serotypes by comparing how often they live harmlessly in the throat versus how frequently they cause serious illness. By calculating case-carrier ratios across diverse global settings, the researchers identified that a strain's likelihood of causing disease is heavily influenced by patient age, HIV status, and national income levels. Crucially, the study reveals that vaccine introduction has shifted these dynamics differently in wealthy versus low-income countries, highlighting a persistent risk from non-vaccine strains in developing regions. Ultimately, these findings provide a refined mathematical framework for health officials to predict future disease outbreaks using simple carriage data.

Lancet February 2026 End-to-end integrative segmentation and radiomics prognostic models for risk stratification of high-grade serous ovarian cancer: a retrospective multicohort study

Tue, 24 Feb 2026 19:35:38 +0000

Researchers have developed an innovative artificial intelligence pipelinedesigned to automate the analysis of medical imaging for patients with high-grade ovarian cancer. By utilizing automated segmentation and radiomics, the model extracts complex data from routine CT scans to predict patient outcomes more accurately than traditional clinical markers. This end-to-end framework successfully identifies high-risk individuals by linking digital imaging patterns to specific biological pathways and invasive phenotypes. Ultimately, this technology offers a non-invasive and scalable way to personalize treatment plans and improve the precision of prognostic assessments in oncology.

Lancet February 2026 Zegocractin for acute pancreatitis with systemic inflammatory response syndrome: a randomized, controlled, dose-ranging, phase 2b trial

Tue, 24 Feb 2026 18:14:12 +0000

This clinical study investigated the efficacy of zegocractin, a novel drug designed to treat acute pancreatitis by blocking specific calcium channels to reduce systemic inflammation. While the drug did not significantly speed up the return to solid food for every participant, it showed significant clinical benefits for patients suffering from more severe forms of the disease. Specifically, higher doses of the medication helped prevent severe respiratory failure and shortened hospital stays for those with high-risk diagnostic markers. By identifying these positive responses in secondary outcomes, researchers have established a strategic foundation for future Phase 3 trials to target the most vulnerable patient populations.

NEJM February 19 2026 An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1

Thu, 19 Feb 2026 18:58:44 +0000

This study investigates a novel medical treatment called del-desiran, an innovative therapy designed to combat myotonic dystrophy type 1 by targeting the underlying genetic cause of the disease. By utilizing a specialized antibody-oligonucleotide conjugate, researchers successfully delivered a corrective molecular message directly to muscle cells to reduce the production of toxic messenger RNA. The clinical trial demonstrated that this approach could effectively lower harmful DMPK levels and improve the accuracy of genetic processing, known as alternative splicing. While the results showed promise in repairing cellular function, the study also meticulously tracked safety and side effects to determine the viability of this treatment for patients with this progressive neuromuscular condition.

NEJM February 19 2026 Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma

Thu, 19 Feb 2026 18:56:51 +0000

This clinical study evaluates the effectiveness of combining two targeted immunotherapies, teclistamab and daratumumab, to treat patients with multiple myeloma who have failed previous therapies. By utilizing a bispecific antibody alongside a monoclonal antibody, this dual approach aims to bridge immune cells directly to cancer cells for more efficient destruction. The research demonstrates that this novel combination significantly improves progression-free survival and achieves higher rates of complete remission compared to standard treatment regimens. While the combination therapy offers a powerful new strategy for controlling the disease, it also carries a slightly higher risk of serious adverse events that must be carefully managed.

JAMA February 5 Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke

Mon, 16 Feb 2026 23:00:28 +0000

The OPTION trial investigated whether the clot-dissolving drug tenecteplase could improve recovery for stroke patients who arrived at the hospital between 4.5 and 24 hours after their symptoms began. By focusing on individuals with non-large vessel occlusions and imaging evidence of salvageable brain tissue, researchers found that those receiving the medication were significantly more likely to achieve an excellent functional outcome compared to those receiving standard care. However, while the treatment improved long-term independence, it also carried a statistically higher risk of symptomatic intracranial hemorrhage. Ultimately, this study suggests that the therapeutic windowfor specialized stroke intervention may be safely extended for a specific subset of patients, provided the benefits are weighed against potential bleeding risks.

JAMA February 11 Coffee and Tea Intake, Dementia Risk, and Cognitive Function.

Mon, 16 Feb 2026 22:50:47 +0000

This extensive longitudinal study tracked over 130,000 individuals for more than four decades to determine how beverage choices influence brain health as we age. Researchers discovered that people who regularly consumed caffeinated coffee and tea faced a significantly reduced risk of developing dementia compared to those who did not. Interestingly, these cognitive benefits were not observed with decaffeinated coffee, suggesting that caffeine plays a vital role in maintaining mental sharpness and slowing perceived decline. The data indicates a nonlinear dose-response relationship, where moderate daily consumption—roughly two to three cups of coffee or one to two cups of tea—offered the most substantial protection for long-term cognitive resilience.

JAMA February 11 Emergency Department–Initiated Buprenorphine for Opioid Use Disorder

Mon, 16 Feb 2026 22:48:12 +0000

This study investigates whether a seven-day injectable dose of medication-assisted treatment in the emergency department is more effective than the standard sublingual tablets for patients with opioid use disorder. Researchers found that both methods yielded comparable rates of treatment engagement at the one-week and one-month marks, suggesting that the long-acting injection is a viable alternative to daily prescriptions. While neither method showed a clear superiority in keeping patients in long-term care, the injectable group reported lower drug cravings and fewer days of illegal substance use. Ultimately, the trial demonstrates that initiating recovery in an emergency setting is safe and well-tolerated, even in a landscape where high-potency synthetic opioids like fentanyl are prevalent.

NEJM February 2026 Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents

Thu, 12 Feb 2026 21:52:20 +0000

This clinical study evaluated whether patients with atrial fibrillation who have lived with a drug-eluting stent for at least one year should take a single anticoagulant or a combination of an anticoagulant and an antiplatelet drug. By tracking the occurrence of major health complications and bleeding over a twelve-month period, researchers discovered that those using only a non-vitamin K antagonist oral anticoagulant (NOAC) experienced significantly fewer adverse clinical events. Most notably, the data revealed that monotherapy substantially reduced the risk of bleeding without compromising the patient's cardiovascular safety. Consequently, the trial concludes that for long-term management, a simplified single-drug regimen is not only as effective as dual therapy but may actually provide a superior safety profile for this specific patient group

NEJM February 2026 A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy

Thu, 12 Feb 2026 21:43:46 +0000

This scientific report details a significant medical study on a new treatment for IgA nephropathy, a common and dangerous kidney disease driven by abnormal immune system activity. Researchers tested a drug called atacicept, which works by blocking specific proteins that fuel the production of harmful antibodies responsible for damaging the kidneys. The study found that patients receiving weekly injections experienced a dramatic reduction in protein loss in their urine compared to those who received a placebo, indicating a much healthier kidney function. By effectively slowing the progression of the disease with mostly mild side effects, this trial suggests that atacicept could provide a vital new defense against kidney failure.

NEJM February 2026 Sibeprenlimab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial

Thu, 12 Feb 2026 20:57:40 +0000

monoclonal antibody designed to block a protein called APRIL that fuels the progression of IgA nephropathy. By neutralizing this key driver, the drug aims to reduce the production of harmful antibodies that damage the kidneys' filtering units. The interim results from this randomized, placebo-controlled trial demonstrate that patients receiving the treatment experienced a significant reduction in proteinuria—a critical marker of kidney stress—compared to those receiving a placebo. Ultimately, the data suggests that sibeprenlimab is a safe and potent intervention capable of drastically lowering the levels of pathogenic proteins while maintaining a side-effect profile comparable to the control group.

Lancet February 2026 Smartwatch-derived versus self-reported outcomes of physiological recovery after COVID-19, influenza, and group A streptococcus: a 2-year prospective cohort study

Mon, 09 Feb 2026 23:05:40 +0000

This research investigates the discrepancy between how patients feel and how their bodies actually function after an illness, using smartwatch datato track physiological markers like heart rate alongside self-reported symptoms. By monitoring thousands of individuals with COVID-19, influenza, and strep throat, the study found a significant digital recovery lag, where internal biological metrics remained abnormal long after participants felt better and resumed their daily routines. This phenomenon was especially pronounced in moderate-to-severe COVID-19 cases, where physical recovery took nearly two months despite symptoms vanishing much sooner. Ultimately, the findings suggest that standard public health guidelines for returning to activity may be too aggressive, and wearable technology could serve as a vital tool for ensuring a truly complete recovery.

Lancet February 2026, Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank

Mon, 09 Feb 2026 23:01:30 +0000

This research study reveals that experiencing delirium during a hospital stay acts as a sentinel event, signaling a widespread and long-term multisystem clinical decline. By comparing thousands of patients, researchers found that those who suffered from delirium were significantly more likely to experience twelve different adverse health outcomes, ranging from physical injuries like falls and hip fractures to severe medical crises such as sepsis and kidney failure. Crucially, this heightened risk exists independently of a patient’s initial frailty or cognitive status, with the danger increasing with each subsequent episode of confusion. Ultimately, the text illustrates that delirium is not just a temporary state of mental fog, but a vital indicator of underlying vulnerability that predicts a broad spectrum of future medical complications.

NEJM February 5,2026 Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer

Thu, 05 Feb 2026 21:20:06 +0000

This clinical study investigates whether a novel drug combination can improve outcomes for patients facing HER2-positive metastatic breast cancer who have not yet received treatment. By comparing a pairing of trastuzumab deruxtecan and pertuzumab against the current standard medical care, researchers found that the new regimen significantly extended progression-free survival, reaching a median of over forty months. While the innovative therapy produced superior tumor response rates, it also carried a specific risk of interstitial lung disease that requires careful monitoring. Ultimately, the trial demonstrates that this treatment duo offers a more effective first-line defense than traditional chemotherapy-based options for managing advanced disease.

NEJM February 5,2026 Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.

Thu, 05 Feb 2026 21:05:08 +0000

This meta-analysis investigated whether prescribing beta-blockersprovides any clinical benefit to heart attack survivors who maintain a normal ejection fraction, a measure of healthy heart pumping function. By aggregating individual data from over 17,000 patients across five major trials, researchers compared those receiving the medication against those who did not over several years. The results clearly demonstrated that beta-blocker therapy offered no significant reduction in the risks of death, subsequent heart attacks, or heart failure for this specific group. Ultimately, the study suggests that the routine use of these drugs may be unnecessary for post-infarction patients whose hearts still pump blood effectively and who lack other medical reasons for the prescription.

NEJM February 5,2026:A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide

Thu, 05 Feb 2026 20:45:59 +0000

This study examines the effectiveness of enlicitide, a novel oral PCSK9 inhibitor, in treating patients with a genetic predisposition for dangerously high cholesterol. Researchers conducted a phase 3 clinical trial to see if this daily pill could further lower LDL-C levels in individuals who were already taking standard medications like statins but had not yet reached their health targets. The results were significant, showing that the drug drastically reduced "bad" cholesterol by nearly 60% compared to a placebo over the course of a year. Ultimately, the trial suggests that enlicitide is a well-tolerated and potent option for managing cardiovascular risk in high-stakes patients who require more aggressive lipid-lowering therapy.

American Journal of HTN January 2026 Trends in Initial Combination Antihypertensive Therapy in a US Health System

Wed, 04 Feb 2026 00:48:45 +0000

Source guide This study examines a concerning shift in medical practice by tracking how often doctors prescribe multiple medications simultaneously to treat newly diagnosed hypertension. Although using a combination of drugsfrom the start is more effective at reaching healthy blood pressure targets, the data reveals a significant decline in this practice over the last decade. Researchers found that as clinicians moved away from these aggressive initial treatments, the overall success rate of blood pressure controlamong patients also dropped. Ultimately, the text serves as a call to action for healthcare providers to return to evidence-based guidelines to ensure patients receive the most effective early intervention possible.

JAMA Network Open ID Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital

Wed, 04 Feb 2026 00:16:25 +0000

This research study evaluates a streamlined treatment method for cryptococcal meningitis, a dangerous fungal brain infection that frequently affects individuals living with HIV. By comparing a single high dose of liposomal amphotericin against the traditional two-week daily regimen, researchers found that the condensed approach resulted in significantly fewer severe side effects and less medical toxicity. The simplified protocol not only maintained survival rates but also led to better patient retention, as fewer individuals left the hospital against medical advice. Ultimately, the findings advocate for the wider adoption of this efficient, patient-centered therapy in high-resource medical settings to improve clinical outcomes and safety.

NEJM January 28, 2026: A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D

Wed, 28 Jan 2026 22:26:57 +0000

This research study evaluates the effectiveness of two experimental drugs, tobevibart and elebsiran, in treating chronic hepatitis D, a serious viral infection. By testing these medications both as a combined therapy and as a single treatment, scientists aimed to see if they could successfully suppress viral levels and restore liver health markers. The results indicate that while both approaches helped patients, the dual-drug regimen was particularly powerful at making the virus undetectable and significantly lowering the surface antigens associated with the disease. Ultimately, the trial demonstrates a promising clinical pathway for managing a difficult condition with manageable side effects.

NEJM January 28,2026 Nivolumab for Resected Stage III or IV Melanoma at 9 Years

Wed, 28 Jan 2026 22:03:05 +0000

The provided text details the long-term results of the CheckMate 238 clinical trial, which evaluated the effectiveness of two immunotherapy drugs in preventing the return of advanced melanoma after surgery. Over a nine-year follow-up period, researchers discovered that patients treated with nivolumab experienced significantly longer recurrence-free survivalcompared to those who received ipilimumab. While both medications showed high rates of overall survival, nivolumab proved superior in delaying the spread of cancer and reducing the necessity for subsequent systemic treatments. Ultimately, the study concludes that nivolumab provides a sustained clinical advantage, offering a more durable defense against cancer relapse without any new long-term safety concerns.

NEJM January 28,2026 Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation

Wed, 28 Jan 2026 21:57:45 +0000

This clinical study investigates whether patients who have undergone a successful catheter ablation for atrial fibrillation still require powerful anticoagulants to prevent future neurological complications. By comparing the efficacy of rivaroxaban against daily aspirin over a three-year period, researchers measured the occurrence of both clinical strokes and "silent" brain damage visible only on imaging. The trial ultimately concluded that using a specialized blood thinner provided no significant clinical advantageover aspirin in reducing the combined risk of stroke or systemic embolism. Furthermore, the findings suggest that the choice of medication did not meaningfully alter the rate of major bleeding events or minor cerebral infarcts among the participants.

NEJM January 22,2026 Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer

Fri, 23 Jan 2026 00:10:37 +0000

This clinical study investigates a promising new treatment combination for patients facing advanced triple-negative breast cancer, a particularly aggressive form of the disease. Researchers compared the effectiveness of pairing the drug sacituzumab govitecan with pembrolizumab against the standard approach of using traditional chemotherapy with immunotherapy. The trial found that patients receiving the new combination therapy experienced a significantly longer duration of progression-free survival, maintaining stability for over eleven months on average. Beyond just slowing the disease, this experimental regimen demonstrated a higher objective response rate and proved easier for patients to tolerate, resulting in far fewer people stopping treatment due to side effects. Ultimately, the study suggests this dual-drug approach offers a superior therapeutic alternativefor previously untreated patients with this specific cancer subtype.

NEJM January 22,2026:Nivolumab for Resected Stage III or IV Melanoma at 9 Years

Thu, 22 Jan 2026 21:49:11 +0000

This long-term clinical study evaluates the effectiveness of two different immunotherapy drugs in preventing the return of advanced melanoma following surgical removal. By tracking patients over a nine-year period, researchers demonstrated that nivolumab provides a more durable defense against cancer recurrence compared to ipilimumab. While both treatments showed similar results regarding total lifespan, patients receiving nivolumab experienced fewer distant metastases and required less follow-up systemic therapy. Ultimately, these final findings confirm that nivolumab remains a superior and safer standard for sustaining remission in high-risk skin cancer patients.

NEJM January 22,2026:Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation.

Thu, 22 Jan 2026 21:47:29 +0000

This clinical trial investigated whether patients who underwent a successful catheter ablation for atrial fibrillation still require powerful blood thinners to prevent future complications. Researchers compared the effectiveness of rivaroxaban against aspirin over a three-year period by monitoring for strokes and hidden brain injuries using MRI technology. The study ultimately found no significant difference between the two medications in reducing the risk of major embolic events for this specific group of patients. These results suggest that for those whose heart rhythm has been restored, the additional protection offered by stronger anticoagulants may not outweigh the potential risks or provide a meaningful advantage over simpler treatments.

NEJM January 2026 Fremanezumab in Children and Adolescents with Episodic Migraine

Thu, 15 Jan 2026 21:17:13 +0000

This study investigated whether fremanezumab, a treatment already used by adults, could effectively reduce the frequency of episodic migraines in children and adolescents. By comparing monthly injections of the drug against a placebo, researchers found that young patients experienced a significant decrease in monthly migraine days and a reduction in the severity of their headaches. Notably, nearly half of the participants receiving the medication saw their migraine frequency cut by at least 50%, suggesting a strong therapeutic benefit. While the drug was generally well-tolerated, with only minor skin redness at the injection site, the authors conclude that continued observation is necessary to confirm the long-term safety and success of this treatment for younger populations.

NEJM January 2026 ORIGINAL ARTICLE Share on Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD

Thu, 15 Jan 2026 19:57:43 +0000

This research study evaluates a groundbreaking subretinal photovoltaic implant designed to combat vision loss caused by geographic atrophy, a severe form of macular degeneration. By utilizing specialized glasses that beam near-infrared light onto a chip behind the retina, the system successfully restored central sight in a high majority of clinical trial participants. Over the course of a year, most subjects experienced a clinically meaningful improvement in their ability to see, while maintaining their existing peripheral vision. Ultimately, the text demonstrates that this innovative neural prosthesis offers a promising solution for patients who previously had no medical options for recovering their lost visual clarity.

NEJM January 2026;Medical Management and Revascularization for Asymptomatic Carotid Stenosis

Thu, 15 Jan 2026 19:32:44 +0000

This research study evaluates the most effective way to treat patients with severely blocked carotid arteries who have not yet experienced symptoms like a stroke. Researchers compared the results of intensive medical management alone against combining that medication with surgical interventions like stenting or endarterectomy. The findings revealed that while surgical stenting significantly lowered the four-year risk of stroke or death compared to drugs alone, the benefits of traditional endarterectomy were not statistically significant. Ultimately, the trial suggests that integrating stenting with modern medicine offers a superior preventative strategy for maintaining long-term neurological health in high-risk patients.

Lancet : January 2026 Mortality and long-term exposure to source-specific PM2·5: evidence from a national cohort study in China

Sun, 11 Jan 2026 20:01:25 +0000

This research investigates how long-term exposure to fine particulate matter from different origins impacts death rates across mainland China. By tracking a diverse group of nearly 97,000 adults over a decade, the study demonstrates that air pollution is not a monolith, as toxins from industrial, residential, and transportation sectors show the strongest links to non-accidental and cardiopulmonary deaths. Notably, the findings highlight that while almost all human-made particles are dangerous, agricultural and industrial emissions are particularly associated with an increased risk of lung cancer. Ultimately, the authors argue that understanding these source-specific health risks is essential for governments to design more precise and effective clean air policies

Lancet : January 2026:SARS-CoV-2 infectious shedding and rebound among adults with and without oral antiviral use: two case-ascertained prospective household studies

Sun, 11 Jan 2026 19:52:37 +0000

This research examined how oral antiviral medications influence the duration of contagiousness and the frequency of viral rebound in patients with COVID-19. By monitoring nasal swabs from high-risk adults, the study found that while treatment initially leads to an earlier cessation of infectious shedding, it also significantly increases the likelihood of a temporary resurgence of the virus. Ultimately, the findings suggest that patients who take antivirals are more likely to experience culture rebound compared to those who do not, though the overall time spent being infectious remains similar between the two groups. This data provides a more nuanced understanding of viral dynamics, helping clinicians and patients better navigate the trade-offs involved in using these medications to manage severe illness.

Lancet : January 2026, REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial

Sun, 11 Jan 2026 19:45:31 +0000

This clinical study investigates a pioneering medical treatment called REGENECYTE, which utilizes umbilical cord blood cells to combat the persistent exhaustion associated with long COVID. By administering multiple intravenous infusions to a small group of patients, researchers discovered that this allogeneic progenitor cell therapy was not only safe but also led to a significant and lasting reduction in physical fatigue. Participants receiving the treatment reported a meaningful boost in their overall quality of life and mental well-being compared to those who received a placebo. Ultimately, these findings suggest that regenerative cell-based therapiesoffer a promising new strategy for managing the most debilitating symptoms of post-viral syndromes.

NEJM January 8, 2026 RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults

Fri, 09 Jan 2026 22:46:34 +0000

This research study evaluates the impact of a specific bivalent vaccine on reducing severe illness from respiratory syncytial virus (RSV) among individuals aged 60 and older. By comparing a large group of vaccinated seniors against an unvaccinated control group during a winter season, researchers discovered that the immunization offered significant protection against serious complications. The data specifically highlights that the vaccine was highly effective at preventing hospitalizations linked to both general and lower respiratory infections caused by the virus. Ultimately, the findings suggest that this medical intervention is a safe and successfultool for decreasing the burden of RSV-related hospital stays in the elderly population.

NEJM January 8, 2026 Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis

Fri, 09 Jan 2026 22:31:39 +0000

This research study evaluates whether daily fish-oil supplements can protect the heart health of patients undergoing long-term hemodialysis, a group that faces a disproportionately high risk of mortality from circulatory issues. By comparing a high dose of omega-3 fatty acids against a placebo over several years, the investigators discovered that those receiving the active treatment experienced significantly fewer major cardiovascular events, including strokes and heart attacks. The data suggests a substantial reduction in the rate of cardiac-related deaths, proving that this simple nutritional intervention is both safe and effective for this vulnerable population. Ultimately, the trial demonstrates that increasing polyunsaturated fatty acid intake serves as a potent preventive therapywhere previous medical options were notably scarce.

NEJM January 8, 2026

Fri, 09 Jan 2026 22:20:58 +0000

A recent clinical study investigated the effectiveness of evolocumab, a PCSK9 inhibitor, in preventing major cardiovascular events for individuals who have never suffered a heart attack or stroke. Researchers conducted a massive trial involving over 12,000 participants with underlying conditions like diabetes or atherosclerosis to see if the medication could lower their initial risk. The results demonstrated that patients receiving the drug experienced significantly fewer life-threatening incidents and arterial procedures compared to those who took a placebo. Over a follow-up period of nearly five years, the treatment proved both statistically effective and safe for primary prevention. These findings suggest that the medication provides a vital protective benefit for high-risk patients before a first major cardiac event occurs. This evidence expands the known clinical utility of the drug beyond just treating patients with a history of vascular disease.

Circulation:January 6, 2026:Circulation:January 6, 2026 Deep Learning–Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation

Mon, 05 Jan 2026 22:27:32 +0000

This research introduces 3DRECON-QT, a sophisticated artificial intelligence system designed to enhance the safety of patients taking specific heart medications by monitoring their cardiac rhythm through a single-lead device. By using deep learning to reconstruct comprehensive spatial data from a limited signal, the model can accurately identify dangerous QT prolongation, a condition that significantly increases the risk of life-threatening arrhythmias. The study demonstrates that this technology achieves guideline-level measurement accuracy, effectively performing as well as standard 12-lead hospital equipment even in outpatient settings. Ultimately, this innovation provides a continuous surveillance strategy that could prevent sudden cardiac events by allowing doctors to intervene the moment a patient’s heart rhythm becomes unstable.

Circulation:January 6, 2026 Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial

Mon, 05 Jan 2026 22:19:59 +0000

The STORM-PE clinical trial investigated whether using a computer-assisted vacuum thrombectomy device to physically remove blood clots provides better outcomes for high-risk pulmonary embolism patients than standard medication alone. By comparing these two treatments, researchers discovered that the mechanical procedure was significantly more effective at reducing heart strain and normalizing vital signs within the first two days of care. While the physical intervention more rapidly restored the balance between heart chambers, it maintained a safety profile comparable to anticoagulation therapy, showing no significant increase in major complications. Ultimately, this study suggests that combining advanced clot-retrieval technology with traditional medicine offers a superior pathway for stabilizing patients facing life-threatening lung obstructions.

Circulation:January 6, 2026 Cardiac Allograft Vasculopathy Inhibition With Alirocumab: The CAVIAR Trial

Mon, 05 Jan 2026 22:18:27 +0000

The CAVIAR trial investigated whether adding the drug alirocumab to standard statin therapy could prevent artery disease in heart transplant recipients, a common cause of post-transplant mortality. While the study confirmed that this combination drastically lowered "bad" cholesterol levels without causing safety concerns, it failed to show a significant clinical benefit regarding physical heart health. Specifically, researchers discovered that the volume of arterial plaque continued to increase regardless of whether patients received the additional medication or a placebo. Ultimately, the study concludes that for patients who already have relatively low cholesterol, the intensive reduction provided by alirocumab does not slow the progression of vascular damage within the first year of recovery.

THE LANCET: December 31, 2025:International trends and social disparities in pain of adults aged 50 years and older in 22 countries across Europe, Asia, and the Americas: a longitudinal population-based study

Sun, 04 Jan 2026 02:01:40 +0000

This longitudinal study examines how chronic physical suffering evolved over two decades among aging populations across twenty-two different nations. By analyzing data from hundreds of thousands of individuals, researchers discovered that pain prevalence is rising globally, though the severity of this trend varies significantly depending on a country's specific geography and policies. The findings highlight a troubling correlation between social disadvantage and physical health, noting that women and those with limited education frequently endure the highest levels of discomfort. Ultimately, the authors argue that persistent pain must be addressed as a critical public health crisis rather than just an individual medical concern, urging leaders to learn from nations that have successfully minimized these health gaps.

THE LANCET Volume 407, Issue 10523P31-52January 03, 2026 Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Sun, 04 Jan 2026 01:57:58 +0000

This comprehensive analysis examines the staggering global impact of domestic and childhood abuse on public health, revealing that over a billion people have endured such trauma. By quantifying the long-term health consequences across 204 countries, the researchers demonstrate that these violations are primary drivers of disability and disease, particularly through severe mental health disorders like depression and self-harm. The study highlights a critical gap in current policy, arguing that these preventable risks should be treated as top-tier public health priorities rather than isolated social issues. Ultimately, the text serves as a call to action for international leaders to increase investments in prevention and survivor support to alleviate a massive, avoidable burden on human life.

N Engl J Med 2026;394:51-61 Dual Targeting of Extramedullary Myeloma with Talquetamab and Teclistamab

Fri, 02 Jan 2026 21:51:16 +0000

patients suffering from a particularly aggressive form of cancer known as true extramedullary myeloma. By simultaneously attacking two different markers on cancer cells using the drugs talquetamab and teclistamab, researchers achieved a high overall response rate in a population that usually faces very poor odds. While the treatment proved effective at shrinking tumors and extending survival, it also carried a high incidence of severe adverse events, specifically regarding infections and hematologic issues. Ultimately, the research suggests that this dual-targeting approachoffers a powerful new strategy for managing drug-resistant disease, provided that the significant safety risks are carefully managed.

NEJM: Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC

Fri, 02 Jan 2026 21:49:16 +0000

This clinical study investigates whether combining the targeted drug osimertinib with traditional chemotherapy offers a superior outcome for patients facing a specific type of advanced lung cancer. By comparing this dual approach against the standard single-drug therapy, researchers discovered that the combination treatment significantly extended the livesof participants by nearly ten months. While the combined regimen proved more effective at keeping the disease at bay, it also resulted in a higher frequency of severe side effects compared to the solo medication. Ultimately, the trial demonstrates a clear survival advantage for this aggressive frontline strategy, providing a more potent but more intensive option for managing this complex malignancy.

N Engl J Med 2026;394:13-26 Sacituzumab Tirumotecan in EGFR-TKI–Resistant, EGFR-Mutated Advanced NSCLC

Fri, 02 Jan 2026 21:38:23 +0000

This study evaluates the effectiveness of sacituzumab tirumotecan, a novel antibody-drug conjugate, for patients with advanced lung cancer whose disease has worsened despite standard treatments. By comparing this new drug against traditional chemotherapy, researchers discovered that it doubled the duration of progression-free survival and significantly extended the lives of those involved in the trial. While side effects like low white blood cell counts were observed, the therapy demonstrated a superior clinical benefit and a manageable safety profile compared to the existing standard of care. Ultimately, the results suggest that this targeted approach offers a transformative secondary treatment option for patients facing resistant forms of EGFR-mutated cancer.

Most Popular Articles JAMA 2025 Episode 2:Screening for Osteoporosis to Prevent Fractures US Preventive Services Task Force Recommendation Statement

Wed, 31 Dec 2025 00:53:52 +0000

This clinical guideline establishes a framework for using medical screenings to identify bone density loss before it leads to debilitating injuries. The document highlights that osteoporotic fractures are severe events that can strip individuals of their independence or even lead to mortality. Based on a rigorous evidence assessment, the task force issues a formal recommendation for all women aged 65 and older, as well as younger postmenopausal women with specific risk factors, to undergo testing. Conversely, the text notes that there is currently insufficient evidence to determine if the benefits of routine screening outweigh the potential harms for the male population. Overall, the text serves as a strategic roadmap for preventative care, aiming to reduce the physical and psychological toll of bone fragility through timely intervention.

Most Popular Articles JAMA 2025 Episode 1:The DECAF Trial

Wed, 31 Dec 2025 00:47:27 +0000

The DECAF Trial challenged the long-held medical assumption that caffeine triggers irregular heart rhythms by investigating its actual impact on patients with atrial fibrillation. Researchers conducted a randomized experiment where one group continued drinking caffeinated coffee while the other practiced complete abstinence following a heart procedure. Surprisingly, the data revealed that those who consumed at least one cup of coffee daily experienced a significantly lower rate of arrhythmia recurrencecompared to those who avoided it. Ultimately, the study suggests that moderate coffee consumption may actually provide a protective benefit for heart rhythm stability rather than acting as a harmful stimulant.

The Lancet December 2025:Neurobehavioural links from infant screen time to anxiety

Wed, 31 Dec 2025 00:39:05 +0000

This research explores how early exposure to digital media impacts the long-term mental health of children by tracing a specific neurodevelopmental pathway from infancy to adolescence. By monitoring brain growth over several years, scientists discovered that excessive screen time during the first two years of life leads to an accelerated maturation of brain networks responsible for vision and cognitive control. This premature structural change eventually manifests as impaired decision-making speeds, which serves as a critical bridge to increased anxiety symptoms by age thirteen. Ultimately, the study reveals that the sensory overstimulation provided by screens may disrupt healthy brain integration, offering a new biological explanation for why limiting early childhood screen use is vital for emotional stability later in life.

Best of JAMA 2025: Episode 9:Nicotinamide for Skin Cancer Chemoprevention

Sat, 27 Dec 2025 21:21:55 +0000

This extensive medical study investigates whether taking nicotinamide, a form of vitamin B3, can effectively serve as a preventative measure against skin cancer for both the general public and high-risk transplant patients. By analyzing health records from over 30,000 veterans, researchers discovered that a daily supplement significantly lowered the overall risk of developing further malignancies, particularly squamous cell carcinoma. The data suggests that the treatment is most powerful when started immediately after a first diagnosis, as the protective benefits appear to diminish if the intervention is delayed until after multiple cancers have occurred. Ultimately, the findings highlight nicotinamide as a promising tool for long-term skin protection, though its effectiveness varies depending on a patient's specific medical history.Å

Best of JAMA 2025: Episode 8:Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use

Sat, 27 Dec 2025 19:52:41 +0000

The CANDIDE study investigated the impact of long-term cannabis use on cardiovascular health by comparing non-users to those who frequently smoke marijuana or consume THC-infused edibles. By measuring how well blood vessels dilate and testing cell reactions to user serum, researchers discovered that both forms of consumption lead to significant endothelial dysfunction, a condition where the lining of the blood vessels fails to function properly. Interestingly, while the physical impairment of the arteries was similar to that caused by tobacco, the underlying biological mechanisms appeared to differ depending on whether the THC was inhaled or ingested. Ultimately, the findings suggest that frequent cannabis use, regardless of the delivery method, may pose a substantial risk to vascular integrity that correlates directly with the frequency and dosage of use.

Best of JAMA 2025: Episode 7: Global Estimates of Lives and Life-Years Saved by COVID-19 Vaccination During 2020-2024

Sat, 27 Dec 2025 18:57:27 +0000

This research provides a comprehensive assessment of the global public health impact of COVID-19 immunizations from 2020 through late 2024. By analyzing diverse demographics and viral waves, the study concludes that vaccines prevented millions of deaths and preserved nearly 15 million life-years, though these benefits were not distributed equally across all age groups. The data reveals that the vast majority of lives saved belonged to individuals aged 60 and older, while the impact on children and young adults was statistically minimal. Ultimately, the authors use these conservative estimates to demonstrate that while the primary protection was concentrated among the elderly, the overall effort resulted in a profound preservation of human life on a global scale.

Best of JAMA 2025: Episode 6:Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related Macular Degeneration

Thu, 25 Dec 2025 22:05:48 +0000

This research study investigates a potential link between popular metabolic medications and a serious vision-threatening condition known as neovascular age-related macular degeneration. By analyzing a massive database of elderly patients with diabetes, scientists discovered that those who used GLP-1 receptor agonists for at least six months faced double the risk of developing this specific eye disease compared to those not taking the drugs. The findings highlight a critical need for clinicians to weigh the systemic benefits of these treatments against possible long-term ocular complications. Ultimately, the study calls for deeper investigation into the biological reasons behind this association to ensure the safe management of patients on long-term therapy.

Best of JAMA 2025: Episode 5:Outcomes of Solid Organ Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors A Systematic Review and Individual Participant Data Meta-Analysis

Tue, 23 Dec 2025 23:11:04 +0000

This comprehensive meta-analysis investigates the delicate balance between treating aggressive cancers and preserving donor organs in solid organ transplant recipients. Researchers discovered that while immune checkpoint inhibitors offer a vital lifeline, they carry a substantial risk of acute rejection and graft loss because the stimulated immune system may attack the transplanted organ. The study highlights that clinical success varies significantly by disease, with cutaneous squamous cell carcinomashowing much better response rates than melanoma or other solid tumors. Ultimately, the findings suggest a potential breakthrough in safety, noting that combining steroids with mTOR inhibitors may shield the graft from rejection without compromising the cancer treatment's effectiveness.

Best of JAMA 2025: Episode 4:Residual Risk of Recurrent Stroke Despite Anticoagulation in Patients With Atrial Fibrillation A Systematic Review and Meta-Analysis

Tue, 23 Dec 2025 23:02:54 +0000

This meta-analysis investigates the residual risk of recurrent stroke in patients with atrial fibrillation who are already receiving modern medical treatment. Despite the widespread use of blood thinners, the study reveals that patients remain at a significant disadvantage, with roughly one in six individuals suffering another ischemic event within five years. The data highlights a particularly high vulnerability for those who experience a stroke while already on anticoagulants, suggesting that current therapies may not be sufficient for all patients. Ultimately, the researchers call for advanced secondary prevention strategies and a deeper investigation into the biological drivers of these persistent cardiovascular threats.

Best of JAMA 2025: Episode 3:Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses

Tue, 23 Dec 2025 22:57:08 +0000

This research explores the intricate genetic link between childhood maltreatment and psychiatric conditions, such as ADHD and depression, by analyzing the DNA of over 100,000 individuals. The study reveals that a person's biological predisposition—specifically genetic markers related to ADHD and educational attainment—can significantly influence their likelihood of experiencing early-life trauma. Even when environmental stressors like parental mental illness are present, an individual’s unique genetic profile remains a powerful predictor of risk. Ultimately, the findings highlight that certain demographics, particularly females with high genetic risk scores, face a much higher probability of maltreatment, suggesting that genetics play a vital role in identifying those who need the most protection.

Best of JAMA 2025: Episode 2:Projected Lifetime Cancer Risks From Current Computed Tomography Imaging

Mon, 22 Dec 2025 23:25:47 +0000

This research study evaluates the health impact of medical imaging by predicting that the roughly 93 million CT scans performed in 2023 will lead to approximately 103,000 future cancer cases. While younger patients face a higher individual risk from ionizing radiation, the sheer volume of procedures in adults—particularly abdominal and chest scans—is responsible for the vast majority of projected illnesses. By highlighting that these screenings could eventually represent 5% of all new cancer diagnoses, the authors underscore a significant public health challenge regarding the long-term safety and frequency of current diagnostic practices.

Best of JAMA 2025: Episode 1: Proximity to Golf Courses and Risk of Parkinson Disease

Mon, 22 Dec 2025 22:16:45 +0000

This scientific study investigates the potential link between pesticide exposure from golf courses and the likelihood of developing Parkinson disease. Researchers discovered that individuals living within a short distance of these facilities faced significantly higher odds of a diagnosis, with the risk generally decreasing as the distance from the greens increased. A major focus of the analysis was drinking water contamination, showing that those residing in areas with vulnerable groundwater or municipal wells near golf courses were particularly susceptible. Ultimately, the text suggests that environmental proximity to chemically maintained landscapes may serve as a critical factor in the onset of this neurological condition.

Lancet:December 19, 2025: Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study

Sun, 21 Dec 2025 20:21:25 +0000

This nationwide Swedish study investigates how the choice of an initial blood pressure medication influences whether a patient will remain on their treatment over several years. By analyzing data from hundreds of thousands of individuals, researchers discovered that those starting with angiotensin receptor blockers (ARBs) demonstrated the highest level of long-term consistency and the fewest changes in therapy. While previous assumptions suggested that only half of patients stick to their prescriptions, this research reveals a more optimistic reality where eighty percent of users continue their regimen over a five-year period. Ultimately, the study suggests that the initial drug class plays a pivotal role in maintaining health habits, effectively challenging old myths about patient non-compliance in hypertension management.

NATURE:Eleven clinical trials that will shape medicine in 2026

Fri, 19 Dec 2025 22:33:53 +0000

This collection outlines a series of groundbreaking clinical trials slated to conclude or produce results by 2026, representing a new frontier in the treatment of chronic and infectious diseases. The text is structured as a survey of diverse medical fields, highlighting innovations such as long-acting HIV antibodies, mRNA-based immunotherapy for autoimmune disorders, and precision gene editing to cure rare genetic defects. Key themes include the shift toward targeted therapies that minimize side effects, the discovery of novel biomarkers like inflammation and specific proteins to prevent heart disease, and the development of more durable vaccines for global health crises. Ultimately, the purpose of this source is to showcase how cutting-edge biotechnology is transitioning from experimental research into practical, life-changing solutions for patients with previously intractable conditions.

The LANCET:Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study Volume 406, Issue 10521P2757-2771December 13, 2025

Thu, 18 Dec 2025 22:42:16 +0000

This study, known as ALIGN-AR, investigated the use of the Trilogy valve, a device specifically engineered for native aortic regurgitation (AR), a condition where older devices optimized for calcific aortic stenosis were not suitable. The research followed high surgical risk patients with symptomatic moderate-to-severe or severe AR undergoing a transcatheter aortic valve intervention (TAVI) to assess the procedure's safety, valve function, and clinical outcomes. The trial successfully met its pre-specified safety composite and all-cause mortality performance goals, demonstrating that TAVI with this purpose-built device is a feasible and effective treatment option for selected high-risk patients by improving functional status and reducing AR.

Neurology: High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia Evidence From a 25-Year Prospective Cohort Study

Thu, 18 Dec 2025 21:39:32 +0000

This study, rooted in a 25-year prospective cohort study of over 27,000 participants in Sweden, sought to clarify the relationship between various dairy product consumption levels and the long-term risk of dementia. Researchers meticulously tracked dietary habits and subsequent diagnoses of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) to discover that higher intake of high-fat cheese and high-fat cream correlated with a statistically reduced risk of all-cause dementia. Conversely, consuming low-fat dairy, milk, or butter showed no significant association with the condition, leading the authors to conclude that the fat content of certain dairy items appears to be a factor in potential dementia risk modification, though the study's observational design limits causal inference.

JAMA December 2026 Valacyclovir Treatment of Early Symptomatic Alzheimer Disease The VALAD Randomized Clinical Trial

Wed, 17 Dec 2025 20:56:28 +0000

This randomized clinical trial, called VALAD, investigated whether the antiviral drug valacyclovir could be an effective treatment for individuals diagnosed with early symptomatic Alzheimer disease who also tested positive for the herpes simplex virus (HSV). The study was motivated by evidence suggesting a potential link between HSV and the etiology of Alzheimer disease. Researchers compared a valacyclovir group and a placebo group over 78 weeks, using the ADAS-Cognitive Subscale scoreas the primary measure of efficacy, along with secondary measures like changes in daily living activities and brain amyloid and tau levels via PET scans. Ultimately, the results indicated that valacyclovir was not efficaciousand, in fact, showed a trend toward greater cognitive worsening compared to the placebo, leading to the conclusion that the drug is not recommended for this patient population.

Annals of Internal Medicine December 2026 Eligibility and Prognostic Performance of Smoking Duration–Based Versus Pack-Year–Based U.S. National Lung Cancer Screening Criteria Across Racial and Ethnic Groups

Wed, 17 Dec 2025 20:35:55 +0000

This research evaluates whether using smoking duration instead of the current pack-year criteria for U.S. national lung cancer screening could improve equity across different racial and ethnic groups. The study utilized a multi-ethnic cohort to compare the eligibility rates and prognostic performance of the 2021 U.S. Preventive Services Task Force (USPSTF-2021) guidelines against a proposed 30-year smoking duration requirement. The findings indicate that the 30-year duration criteria significantly reduces the screening eligibility disparities between African Americans and Latinos relative to White participants, while also modestly increasing the sensitivity for detecting lung cancer within six years across all groups. Although a risk-based model was also tested and performed well overall, it ultimately widened the eligibility gap for Latino populations, supporting the conclusion that duration-based criteria are a more equitable alternative for lung cancer screening.

NEJM December 2026 Part III

Tue, 16 Dec 2025 20:16:00 +0000

NEJM articles:

Volume 393

No. 23

December 11, 2025

This research details a phase 3 randomized clinical trial comparing a novel combination therapy to traditional chemotherapy for patients with HER2-expressing advanced urothelial cancer. The study investigated the efficacy of disitamab vedotin, a HER2-targeting antibody–drug conjugate, combined with the PD-1 immunotherapy toripalimab against standard gemcitabine plus cisplatin or carboplatin. The compelling results showed that the combination therapy significantly extended progression-free survival (13.1 vs. 6.5 months) and overall survival (31.5 vs. 16.9 months) compared to chemotherapy, while also demonstrating a more favorable safety profile with fewer high-grade adverse events. Ultimately, the trial concluded that disitamab vedotin–toripalimab offers a considerable improvement in outcomes for this specific patient population.

NEJM December 2026 Part II

Tue, 16 Dec 2025 20:05:12 +0000

NEJM articles:

Volume 393

No. 23

December 11, 2025

This clinical trial investigated whether adding the drug ticagrelor to standard aspirin therapy would improve outcomes for patients who had undergone coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Researchers randomly assigned over 2,200 patients across Nordic centers to receive either the combination therapy or aspirin alone for one year to evaluate a primary outcome that included death, stroke, or heart attack. The results demonstrated that the dual-therapy group did not have a lower incidence of these serious adverse cardiovascular events compared to the aspirin-alone group. Furthermore, the combination of ticagrelor and aspirin was associated with a significantly increased risk of major bleeding, suggesting no clinical benefit for this specific patient population.

NEJM December 11 2026

Tue, 16 Dec 2025 19:58:41 +0000

NEJM articles:

Volume 393

No. 23

December 11, 2025

The provided text summarizes two distinct, large-scale, randomized controlled trials investigating the effectiveness of the high-dose inactivated influenza vaccine compared to the standard dose in older adults (aged 65 and older). Both studies sought to determine if the high-dose vaccine offered superior protection against severe clinical outcomes, primarily focusing on the composite primary endpoint of hospitalization for influenza or pneumonia. The Danish trial, involving over 330,000 participants, ultimately did not find a significantly lower incidence of this primary outcome with the high dose, although it noted a strong effectiveness against hospitalization specifically for influenza. Conversely, the Spanish trial, which focused on a slightly younger group (ages 65 to 79), concluded that there appeared to be fewer hospitalizations for influenza or pneumonia in those receiving the high-dose vaccine, suggesting conflicting findings regarding overall efficacy against severe complications.

10 27 2025

Mon, 27 Oct 2025 09:42:48 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Hypertonic Saline or Carbocisteine in Bronchiectasis

Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation

Common Diseases in Clinical Cohorts — Not Always What They Seem

Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis

Journal of American Medical Association

Bioresorbable vs Metallic Occluders for Transcatheter Atrial Septal Defect Closure

Annals of Internal Medicine

Trends in Cancer Incidence in Younger and Older Adults: An International Comparative Analysis

British Medical Journal

Sodium-glucose cotransporter-2 inhibitors and risk of autoimmune rheumatic diseases

JAMA oncology

Risk Factors for Valvulopathy Among Childhood Cancer Survivors

Gastroenterology

Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection

Clinical Gastroenterology

Prevalence and Pathophysiology of Loose Stools and Their Impact on Clinical Severity and Quality of Life in Women With Fecal Incontinence

Clinical Infectious Diseases

Phase 1 Evaluation of VH4524184, a Third-Generation Integrase Strand Transfer Inhibitor With an Enhanced Resistance Profile

Journal of Clinical Rheumatology

A Novel Scoring System for Diagnosing Systemic Lupus Erythematosus–Related Cytopenias: Insights From a Cohort Study

Circulation

Redefining the Genetic Architecture of Hypertrophic Cardiomyopathy: Role of Intermediate-Effect Variants

Journals of the American College of Cardiology

Trade-Off Between Bleeding and Ischemic Events From Left Ventricular Assist Devices: A EUROMACS Registry Analysis

JAMA Cardiology

Age-Stratified Effect of Rivaroxaban Monotherapy for Atrial Fibrillation in Stable Coronary Artery DiseaseA Post Hoc Analysis of the AFIRE Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Using a Composite Summary of Daily Sex Hormones to Gauge Time Until Menopause: A Focus on Pregnanediol Glucuronide (PDG)

Diabetes care

Differential Effect of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Lower-Extremity Amputation Outcomes in Type 2 Diabetes: A Nationwide Retrospective Cohort Study

Neurology

Soccer Heading Exposure–Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players

Chest

Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults

Clinical Journal of American Society of Nephrology

Comparative Effectiveness of Lubiprostone and Stool Softeners on Risk of Kidney Outcomes in Patients with CKD

Kidney International reports

Randomized Trial of Dapagliflozin in Patients With Nondiabetic Stage 4 CKD

10 21 2025

Mon, 20 Oct 2025 08:12:56 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality

Journal of American Medical Association

Intra-Arterial Alteplase After Successful Endovascular Reperfusion in Acute Stroke

The PEARL Randomized Clinical Trial

Annals of Internal Medicine

Effectiveness of Recombinant Herpes Zoster Vaccine in the U.S. Medicare Population, 2018 to 2019, by Immunocompetence and Prior Receipt of Live Zoster Vaccine

British Medical Journal

Sodium-glucose cotransporter-2 inhibitors and risk of autoimmune rheumatic diseases: population based cohort study

Lancet

The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023

JAMA oncology

Pathogenic Variants, Family History, and Cumulative Risk of Breast Cancer in US Women

Gastroenterology

Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): A Multicenter Randomized Controlled Trial

Clinical Gastroenterology

Safety and Efficacy of Endoscopic Submucosal Dissection for Rectal Neoplasms Extending to the Dentate Line: A Systematic Review and Meta-analysis

Clinical Infectious Diseases

Dolutegravir/Lamivudine for Maintenance of Virological Suppression in Persons With Historical Suspected or Confirmed Resistance to Lamivudine: Week 48 Results of a Single-Arm, Open-Label, Multicenter, Phase IIa Clinical Trial

Journal of Clinical Rheumatology

Knowledge and Behaviors in Reproductive Health Among Mexican Women With Autoimmune Rheumatic Diseases: Cross-sectional Study

Circulation

Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort

Journals of the American College of Cardiology

Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women

JAMA Cardiology

Efficacy and Tolerability of Finerenone According to the Use and Dosage of DiureticsA Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor

Chest

The Association Between Mechanical Power Within the First 24 Hours and ICU Mortality in Mechanically Ventilated Adult Patients With Acute Hypoxemic Respiratory Failure

The American Journal of Respiratory and Critical Care Medicine

One-Year Change in Quantitative Computed Tomography Is Associated with Meaningful Outcomes in Fibrotic Lung Disease

Clinical Journal of American Society of Nephrology

The Association of Long COVID and CKD: Findings from the National Clinical Cohort Collaborative

Kidney International reports

Effects of Combination Treatment on Renal Endothelial Function in Type 2 Diabetes Mellitus

9 29 2025

Mon, 29 Sep 2025 06:48:35 +0000

Here are the articles from Kidney International reports

A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation

Introduction

The interferon gamma (IFN-γ) enzyme-linked immunosorbent spot is a highly sensitive immune assay that enables the assessment of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) and can identify at-risk transplant patients of CMV infection; however, its clinical implementation remains elusive.

Conclusion

We developed a robust CMV-PrognosTIC score to quantify the risk of CMV infection in SOT, which may be readily implemented in clinical transplantation to personalize CMV preventive therapies.

Self-Reported Outcome of Living Kidney Donation Correlates With Perioperative Complications not With Surgical Techniques

Introduction

The German health care system lacks data on surgical complications and self-reported outcomes (SROs) of living donors. The prospective German Living Kidney Donor Registry, SOLKID-GNR aims to improve the assessment of donors’ medical and psychosocial risks.

Conclusion

Although the surgical technique does not directly affect donors' QoL shortly after donation, minimally invasive procedures result in shorter hospital stays and a quicker return to work. Self-reported complications have a greater impact on mental QoL than those documented by transplant centers, highlighting the importance of subjective experiences during recovery.

9 22 2025

Mon, 22 Sep 2025 10:31:46 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation

Journal of American Medical Association

Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia

Annals of Internal Medicine

The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity

British Medical Journal

Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016

Lancet

Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2): a multicentre, participant-masked, registry-based, randomised controlled trial

JAMA oncology

Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses

Falls Among Individuals With Systemic Lupus Erythematosus: An Observational Study

Journals of the American College of Cardiology

Safety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation

JAMA Cardiology

One-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST ElevationAn Individual Patient Data Meta-Analysis

Journal of Clinical Endocrinology & Metabolism

Association Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018

Diabetes care

A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.

Neurology

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

Chest

Investigating the Long-Term Effects of COVID-19 Infection on Health Care Utilization in Individuals With COPD

The American Journal of Respiratory and Critical Care Medicine

Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation

Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD: A Meta-Analysis of Kidney Outcome Trials

Kidney International reports

Prospective Pilot Study of Plasma Cell–Targeted Therapy With Bortezomib in Refractory IgA Nephropathy

Community-Acquired Acute Kidney Injury and Late Kidney Dysfunction in Survivors of COVID-19 Hospitalization

9 15 2025

Mon, 15 Sep 2025 08:16:50 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy

Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

Multidomain Rehabilitation for Older Patients with Myocardial Infarction

Journal of American Medical Association

Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis

The PRIME Diagnostic Clinical Trial

Annals of Internal Medicine

Exposure to CT and Pregnancy Outcomes

British Medical Journal

Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016

Lancet

Benefit–harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trials

JAMA oncology

Debt, Bankruptcy, and Credit Scores After Cancer Diagnosis

Journal of Clinical Rheumatology

Pilot Study: Development and Evaluation of Validity Evidence of a Low-Cost, Low-Fidelity Hand Model to Teach Clinical Assessment of Small Joint Swelling in Inflammatory Arthritis

Journals of the American College of Cardiology

Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease

JAMA Cardiology

Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events

Journal of Clinical Endocrinology & Metabolism

YAP1 Is a Prognostic Marker and Its Inhibition Reduces Tumor Progression in Adrenocortical Tumors

Diabetes care

Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease

Neurology

Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors

Chest

Association of Timely Spirometry With Lower All-Cause Mortality

Risk Factors for Patient-Important Upper Gastrointestinal Bleeding

Clinical Journal of American Society of Nephrology

Pregnancy and Long-Term Kidney Function in CKD: A Systematic Review and Meta-Analysis

Kidney International reports

Meta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus

A Systematic Review of Sleep Hygiene Strategy in CKD

8 25 2025

Mon, 25 Aug 2025 06:03:41 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer

Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer

Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis

Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma

Journal of American Medical Association

Annals of Internal Medicine

Measurement Error and the Cost-Effectiveness of Intensive Blood Pressure Targets

Effect of lateral versus supine positioning on hypoxaemia in sedated adults

Lancet

Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial

JAMA oncology

Sintilimab Plus Axitinib for Advanced Fumarate Hydratase–Deficient Renal Cell CarcinomaA Phase 2 Nonrandomized Clinical Trial

Clinical Infectious Diseases

Journal of Clinical Rheumatology

Noninfectious Uveitis in Pediatric Rheumatology: Long-term Follow-up at Tertiary Centers

Circulation

A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients With Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial

Journals of the American College of Cardiology

Paclitaxel-Coated Balloon for the Treatment of Multilayer In-Stent Restenosis: AGENT IDE Subgroup Analysis

JAMA Cardiology

Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events

Journal of Clinical Endocrinology & Metabolism

Association Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018

Diabetes care

In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth

Neurology

Use of Disease-Modifying Therapies in Patients With Late-Onset Multiple Chest

Normosol-R vs Lactated Ringers in the Critically Ill

The American Journal of Respiratory and Critical Care Medicine

Mechanically Affected Lung and Progression of Emphysema

Clinical Journal of American Society of Nephrology

Population Health Management Impact on Healthcare Utilization and Costs in CKD: Post Hoc Analysis of the Kidney Coordinated HeAlth Management Partnership Trial

Sex Differences in the EXerCise Introduction to Enhance Performance in Dialysis Trial

Kidney International reports

Economic Evaluation of System-Wide Implementation of Kidney Supportive Care

Impact of Improved Diagnosis and Treatment on Holistic CKD Burden

8 18 2025

Mon, 18 Aug 2025 09:36:27 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity

Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

Journal of American Medical Association

Dalbavancin for Treatment of Staphylococcus aureus Bacteremia

Annals of Internal Medicine

Geographic Variation in Receipt of Care by Specialized Oncologists

British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

Lancet

Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy

JAMA oncology

Integrating Quality of Life and Survival in Systemic Therapy for Advanced Hepatocellular CarcinomaA Network Meta-Analysis

Clinical Gastroenterology

Noninvasive Disease Assessment in Eosinophilic Esophagitis With Fractionated Exhaled Nitric Oxide, Blood, and Fecal Biomarkers

Clinical Infectious Diseases

Journal of Clinical Rheumatology

Validation of the ANCA-Associated Vasculitis Patient-Reported Outcomes Questionnaire in a Latin American Vasculitis Cohort

Circulation

Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease

Journals of the American College of Cardiology

Recurrent Events Analysis of MASTER DAPT: Total Ischemic and Bleeding Events After Abbreviated vs Prolonged DAPT in HBR Patients

JAMA Cardiology

Early Childhood Food Insecurity and Cardiovascular Health in Young Adulthood

Journal of Clinical Endocrinology & Metabolism

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

Diabetes care

Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy

Neurology

Real-World Evidence of Brexpiprazole Use and 6-Month Mortality, Hospitalization, and Emergency Department Visits Among Persons With Dementia

Chest

Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients

A Randomized Controlled Trial

The American Journal of Respiratory and Critical Care Medicine

Endotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4)

Clinical Journal of American Society of Nephrology

Core Outcome Measure for Life Participation in Patients with CKD: Standardized Outcomes in Nephrology Workshops Report

Frailty in Adults with CKD and Validation of the Kidney Failure Risk Equation in Frailty Subgroups

Kidney International reports

A Systematic Review of Treatment for Acute Interstitial Nephritis

Double-Icodextrin Dose Randomized Controlled Trial of a Double Icodextrin Dose for Older Patients on Incremental Continuous Ambulatory Peritoneal Dialysis

8 11 2025

Mon, 11 Aug 2025 09:02:54 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes

Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague

Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer

First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

Journal of American Medical Association

Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours

Annals of Internal Medicine

Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain: A Randomized Controlled Trial

JAMA oncology

Modeling Population-Level Impacts of Cell-Free DNA Screening for Colorectal Cancer in Canada

Journal of Clinical Oncology

Randomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer

journal of Hepatology

A phase IIb randomised-controlled trial of the FFAR1/FFAR4 agonist icosabutate in MASH

Gastroenterology

Risk of Gastric Adenocarcinoma After Eradication of Helicobacter pylori

Clinical Gastroenterology

Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders

Clinical Infectious Diseases

Target Trial Emulation of SARS-CoV-2 Infection Versus No Infection and Risk of Post–COVID-19 Conditions in the Omicron Variant Versus Prior Eras

Rheumatology

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

Circulation

Abelacimab Versus Rivaroxaban in Patients With Atrial Fibrillation on Antiplatelet Therapy: A Prespecified Analysis of the AZALEA-TIMI 71 Trial

Journals of the American College of Cardiology

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial

JAMA Cardiology

Cumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk

Journal of Clinical Endocrinology & Metabolism

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

Diabetes care

Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy

Neurology

Statin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020: A Target Trial Emulation Study

The American Journal of Respiratory and Critical Care Medicine

Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter-2 Inhibitor Therapy and Longitudinal Changes in Kidney Function among Veterans with Autosomal Dominant Polycystic Kidney Disease

Here are the articles from Kidney International reports

A Systematic Review of Treatment for Acute Interstitial Nephritis

8 4 2025

Mon, 04 Aug 2025 10:00:39 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery

Journal of American Medical Association

Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures in Veterans

Annals of Internal Medicine

Social Determinants of Health and Long COVID

British Medical Journal

Sex related differences in efficacy and safety of antithrombotic therapy in patients with coronary artery disease

Lancet

Adjuvant chemotherapy and hormonotherapy versus adjuvant hormonotherapy alone for women aged 70 years and older with high-risk breast cancer based on the genomic grade index (ASTER 70s): a randomised phase 3 trial

JAMA oncology

First-Line Therapy For Advanced Non–Clear Cell Renal Cell CarcinomaA Systematic Review and Meta-Analysis

journal of Hepatology

Carvedilol vs. propranolol for the prevention of decompensation and mortality in patients with compensated and decompensated cirrhosis

Gastroenterology

Mebeverine and the Influence of Labeling in Adolescents With Irritable Bowel Syndrome or Functional Abdominal Pain Not Otherwise Specified: A 2 × 2 Randomized, Placebo-Controlled Trial

Clinical Gastroenterology

Association Between the Inflammatory Potential of Diet and Constipation Among Adults in the United States: A Cross-sectional Study

Circulation

Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy

Journals of the American College of Cardiology

10-Year Outcome of Complete or Infarct Artery-Only Revascularization in STEMI With Multivessel Disease: The DANAMI-3-PRIMULTI Study

JAMA Cardiology

Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection FractionThe FINEARTS-HF Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Tumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer

Diabetes care

Associations of AMH in Midreproductive Years with Bone Mineral Density and Turnover Markers in Midlife

Neurology

Risk of Ventricular Arrhythmia and Sudden Cardiac Arrest Among Older Patients Using Lamotrigine for Epilepsy

Chest

Trajectories of Interferon-Gamma Release Assay Results Over 2 Years in Independent Cohorts From China, South Africa, Tanzania, and the United States

The American Journal of Respiratory and Critical Care Medicine

Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial

Clinical Journal of American Society of Nephrology

Decision Readiness and Determinants of KRT among Veterans with Advanced CKD

Kidney International reports

Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study)

7 28 2025

Mon, 28 Jul 2025 09:24:45 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy

Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer

Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy

Ivermectin to Control Malaria — A Cluster-Randomized Trial

Journal of American Medical Association

Telehealth and Online Cognitive Behavioral Therapy for Chronic Pain

Annals of Internal Medicine

Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes

British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

JAMA oncology

Nivolumab and Ipilimumab Combination Treatment in Advanced Ovarian and Endometrial Clear Cell CancersA Nonrandomized Clinical Trial

journal of Hepatology

All-cause and cause-specific mortality in patients with chronic hepatitis B and concurrent steatotic liver disease

Gastroenterology

Capsule Endoscopy–Guided Proactive Treat-to-Target Versus Continued Standard Care in Patients With Quiescent Crohn’s Disease: A Randomized Controlled Trial

Clinical Gastroenterology

Real-world Clinical Effectiveness and Safety of Vedolizumab and Adalimumab in Biologic-naive Patients With Crohn’s Disease: Results From the EVOLVE Study

Circulation

Efficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial

Journals of the American College of Cardiology

Biolimus-Eluting Biomatrix Stent vs a Dual-Therapy Sirolimus-Eluting Stent in PCI: The SORT OUT XI Randomized Trial

JAMA Cardiology

OCT vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified LesionsThe CALIPSO Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

The Role of Whole Food Plant-Based Food Intake on Postprandial Glycemia in Type 1 Diabetes

Diabetes care

Associations of Concurrent Hypertension and Type 2 Diabetes With Mortality Outcomes: A Prospective Study of U.S. Adults

Chest

Clinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma

The American Journal of Respiratory and Critical Care Medicine

Deep Learning Estimation of Small Airway Disease from Inspiratory Chest Computed Tomography: Clinical Validation, Repeatability, and Associations with Adverse Clinical Outcomes in Chronic Obstructive Pulmonary Disease

Clinical Journal of American Society of Nephrology

Unveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization

Here are the articles from Kidney International reports

Characterization of Monogenic Kidney Disease in Older Patients With CKD

7 21 2025

Mon, 21 Jul 2025 05:50:31 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer

First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate

Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin

Journal of American Medical Association

Hepatitis C Screening in Emergency Departments

The DETECT Hep C Randomized Clinical Trial

Annals of Internal Medicine

Vaporized Nicotine Products for Smoking Cessation Among

British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

Lancet

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial

Journal of Clinical Oncology

Acalabrutinib Plus Bendamustine-Rituximab in Untreated Mantle Cell Lymphoma

Gastroenterology

Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial

Clinical Gastroenterology

Budesonide Versus Mesalamine in Microscopic Colitis: A Comparative Meta-analysis of Randomized Controlled Trials

Circulation

Pulsed Field Ablation of Persistent Atrial Fibrillation With Continuous Electrocardiographic Monitoring Follow-Up: ADVANTAGE AF Phase 2

Journals of the American College of Cardiology

Impact of Optical Coherence Tomography-Based Post-PCI Physiology Assessment to Predict Clinical Outcomes: An ILUMIEN-IV Substudy

JAMA Cardiology

Emergency Department–Based Education and mHealth Empowerment Intervention for HypertensionThe TOUCHED Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Clomiphene Citrate Medication for Infertility and Risk of Stillbirth or Neonatal Death: A Population-based Cohort Study

Diabetes care

Comparison of Serum Creatinine– and Cystatin C–Based eGFR at Baseline and Their Prediction of Incident Moderate Albuminuria in Individuals With Type 1 Diabetes

Neurology

Lamotrigine and Cardiac Arrhythmias: A Target Trial Approach

Chest

Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation

mThe American Journal of Respiratory and Critical Care Medicine

Airway Scaffolds for Emphysema-related Hyperinflation: Six-Month Results from the BREATHE Trial

Clinical Journal of American Society of Nephrology

The Emerging Nephrology Physician Workforce in the United States: Defining an Impending Shortfall

Kidney International reports

Point-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India

7 14 2025

Mon, 14 Jul 2025 09:04:36 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

As-Needed Albuterol–Budesonide in Mild Asthma

Global Effect of Cardiovascular Risk Factors on Lifetime Estimates

Intravenous Tenecteplase before Thrombectomy in Stroke

Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer

Journal of American Medical Association

Obesity Variation Among Asian, Native Hawaiian or Pacific Islander Adults in the US

Annals of Internal Medicine

Development and Validation of Body Mass Index–Specific Waist Circumference Thresholds in Postmenopausal Women

British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

Lancet

Mitapivat in adults with non-transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE): a phase 3, international, randomised, double-blind, placebo-controlled trial

JAMA oncology

Adjuvant Chemoradiation and Immunotherapy for Extrahepatic Cholangiocarcinoma and Gallbladder CancerA Randomized Clinical Trial

Journal of Clinical Oncology

Use of Low-Value Cancer Treatments in Medicare Advantage Versus Traditional Medicare

journal of Hepatology

Modeling the health and economic impact of pharmacologic therapies for MASLD in the United States

Gastroenterology

Diagnostic Accuracy of Timed Barium Esophagram for Achalasia

Clinical Gastroenterology

Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders

Rheumatology

Association of Soluble Immune Checkpoint Molecules PD1 and 4-1BB With CTLA-4Ig Treatment Response in Early Rheumatoid Arthritis

Circulation

Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study

Journals of the American College of Cardiology

Plaque Vulnerability and Cardiovascular Risk Factor Burden in Acute Coronary Syndrome: An Optical Coherence Tomography Analysis

JAMA Cardiology

Cumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk

Journal of Clinical Endocrinology & Metabolism

Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes

Diabetes care

Economic Costs Attributed to Diagnosed Diabetes in Each U.S. State and the District of Columbia: 2021

Neurology

Neighborhood Socioeconomic Status and the Functional Outcome of Patients Treated With Endovascular Thrombectomy for Ischemic Stroke

Chest

Prolonged Mechanical Ventilation in Critically Ill Patients

he American Journal of Respiratory and Critical Care Medicine

Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics

Clinical Journal of American Society of Nephrology

High Heat Exposure and Medical Utilization among the CKD Population

Kidney International reports

Holistic Impact of CKD: A Clinical, Economic, and Environmental Analysis by IMPACT CKD

7 7 2025

Mon, 07 Jul 2025 10:01:31 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer

Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

Journal of American Medical Association

Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension: The Launch-HTN Randomized Clinical Trial

Annals of Internal Medicine

Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses

A Retrospective Cohort Study

British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

Lancet

Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial

Gastroenterology

Noncontrast Magnetic Resonance Imaging vs Ultrasonography for Hepatocellular Carcinoma Surveillance: A Randomized, Single-Center Trial

Clinical Gastroenterology

Esophageal Expert Development of a Preliminary Question Prompt List for Adults With Eosinophilic Esophagitis: A Modified Delphi Study

Clinical Infectious Diseases

Glucocorticoid Dosing and Implications for Vaccination: Evolution of Global Definitions

Journal of Clinical Rheumatology

Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)

Circulation

FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1

Journals of the American College of Cardiology

Long-Acting Factor XI Inhibition and Periprocedural Bleeding: An Analysis From AZALEA-TIMI 71

JAMA Cardiology

Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation

Journal of Clinical Endocrinology & Metabolism

Cost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism

Diabetes care

Impact of Islet Transplantation on Diabetes Complications and Mortality in Patients Living With Type 1 Diabetes

Neurology

Association of Predicted Visceral Fat Percentage With Dementia Risk in Older Adults: The Role of Genetic Risk and Lifestyle

Chest

Ventilator-Associated Pneumonia in Low- and Middle-Income vs High-Income Countries

The American Journal of Respiratory and Critical Care Medicine

Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation

Clinical Journal of American Society of Nephrology

High Heat Exposure and Medical Utilization among the CKD Population

Kidney International reports

Effect of Sleep Characteristics on Rapid Estimated GFR Decline in Adults with Normal Kidney Function

6 30 2025

Mon, 30 Jun 2025 09:34:55 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation

Efruxifermin in Compensated Liver Cirrhosis Caused by MASH

Journal of American Medical Association

Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning

Annals of Internal Medicine

Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses

British Medical Journal

Effect of UK Quality and Outcomes Framework pay-for-performance programme on quality of primary care

journal of Hepatology

Histological severity, clinical outcomes and impact of antiviral treatment in indeterminate phase of chronic hepatitis B: A systematic review and meta-analysis

Clinical Gastroenterology

The Tissue Systems Pathology Test Objectively Risk-Stratifies Patients With Barrett’s Esophagus: Results From a Multicenter US Clinical Experience Study

Delayed Perforation After Endoscopic Resection of Upper Gastrointestinal Tumors: CT Findings to Identify Patients Requiring Surgery

Clinical Infectious Diseases

Antimicrobial Stewardship and Beyond: The Many Essential Roles of Infectious Diseases Pharmacists

Circulation

Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF

Journals of the American College of Cardiology

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension:

JAMA Cardiology

Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant UseA Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence

Diabetes care

Cellular Versus Acellular Matrix Products for Diabetic Foot Ulcer Treatment: The Dermagraft and Oasis Longitudinal Comparative Efficacy Study (DOLCE)—A Randomized Clinical Trial

Neurology

Noninvasive Assessment of the Risk Features of Hemorrhage in Moyamoya Disease Using 7T MRI

Chest

Preserved Ratio Impaired Spirometry Prevalence, Risk Factors, and Outcomes

The American Journal of Respiratory and Critical Care Medicine

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome

Clinical Journal of American Society of Nephrology

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with and without Advanced CKD: Systematic Review and Meta-Analysis

Kidney International reports

Dotinurad Treatment for Patients With Hyperuricemia Complicating CKD

6 9 2025

Mon, 09 Jun 2025 09:10:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules

Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy

A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes

Journal of American Medical Association

Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer

Annals of Internal Medicine

Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery

Lancet

Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial

Journal of Clinical Oncology

Explaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study

journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

Clinical Infectious Diseases

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes

Rheumatology

Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases

Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

JAMA Cardiology

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis

Diabetes care

Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials

Neurology

Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

Chest

Clinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis

The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

Clinical Journal of American Society of Nephrology

Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression

Kidney International reports

Nephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists

6 2 2025

Mon, 02 Jun 2025 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis

Journal of American Medical Association

Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

The KARDIA-2 Randomized Clinical Trial

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

The A2B Randomized Clinical Trial

Annals of Internal Medicine

Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States

British Medical Journal

A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China

Lancet

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial

journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

Rheumatology

Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease

Journal of Clinical Rheumatology

Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis

Circulation

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension

Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

JAMA Cardiology

Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration

Journal of Clinical Endocrinology & Metabolism

Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study

Neurology

Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years

Chest

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest

The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

Clinical Journal of American Society of Nephrology

High-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD

Kidney International reports

Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease

5 26 2025

Mon, 26 May 2025 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Second-Line Antiretroviral Therapy for Children Living with HIV in Africa

Journal of American Medical Association

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial

A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease

Annals of Internal Medicine

Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide

British Medical Journal

Effects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial

Lancet

Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial

Gastroenterology

Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort

Clinical Gastroenterology

The Lactulose Breath Test Can Predict Refractory Gastroesophageal Reflux Disease by Measuring Bacterial Overgrowth in the Small Intestine

Rheumatology

A Catalog of “Knee Friendly” Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey

Journal of Clinical Rheumatology

Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)

Circulation

Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry

Journals of the American College of Cardiology

Effect of Empagliflozin on the Mechanisms Driving Erythropoiesis and Iron Mobilization in Patients With Heart Failure: The EMPEROR Program

JAMA Cardiology

Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity

Journal of Clinical Endocrinology & Metabolism

Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome

Diabetes care

Early Fasting Serum Glucose or Weight Reduction With Tirzepatide and Metabolic Outcomes in People With Type 2 Diabetes: A Post Hoc Analysis of the SURPASS Trials

Neurology

Risk of False Acetylcholine Receptor Autoantibody Positivity by Radioimmunoprecipitation Assay in Clinical Practice

Chest

Low-Dose Melatonin for Prevention of Delirium in Critically Ill Patients

The American Journal of Respiratory and Critical Care Medicine

Population-Based Screening for Chronic Obstructive Pulmonary Disease Using the St. George’s Respiratory Questionnaire in Resource-Limited Settings

Clinical Journal of American Society of Nephrology

Predicting Kidney Outcomes in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Biomarker Analysis

Kidney International reports

Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy

5 19 2025

Mon, 19 May 2025 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis

Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis

Journal of American Medical Association

Spironolactone vs Amiloride for Resistant Hypertension

Annals of Internal Medicine

Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025

British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study

Lancet

Clinical presentation and epidemiological assessment of confirmed human mpox cases in DR Congo: a surveillance-based observational study

journal of Hepatology

A new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD

Gastroenterology

Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares

Clinical Gastroenterology

Reproducibility of the AGREE II Tool for Assessing the Methodological Quality of Clinical Practice Guidelines for the Management of Antithrombotic Agents in Patients Undergoing GI Endoscopy

Circulation

Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes

Journals of the American College of Cardiology

Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial

JAMA Cardiology

Trajectory of Cardiovascular Health Across Childhood and Adolescence

Journal of Clinical Endocrinology & Metabolism

Renal Protective Effect of Metformin in Type 2 Diabetes Patients

Diabetes care

Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease

Neurology

Endovascular Thrombectomy for Large Ischemic Core Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chest

Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes

The American Journal of Respiratory and Critical Care Medicine

Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma

Clinical Journal of American Society of Nephrology

Dialysis Dependence in Standard versus Accelerated Initiation of KRT in AKI: A Post Hoc Analysis

Kidney International reports

Scoping Review of Kidney Patients and Providers Perspectives on Disaster Management

5 1 2025

Mon, 05 May 2025 19:45:19 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a)

Identification of Hepatic-like EPO as a Cause of Polycythemia

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1

Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype

Journal of American Medical Association

Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence

The MUSA Randomized Clinical Trial

Annals of Internal Medicine

Sexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans

British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm

Lancet

Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study

Journal of Clinical Oncology

Supervised Exercise for Patients With Metastatic Breast Cancer

journal of Hepatology

Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B

Gastroenterology

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood

Journal of Clinical Rheumatology

Salivary β2-Microglobulin, Na+, and Cortisol Levels, and Salivary Glands' Uptakes in Sialoscintigraphy in Sjögren Disease

Circulation

Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

Journals of the American College of Cardiology

Nonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves: Exposure Response in 2.39 Million Patients

From JAMA Cardiology

Salt Substitution and Recurrent Stroke and DeathA Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Digital Voice Analysis as a Biomarker of Acromegaly

Chest

Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices

The Lactel Randomized Multicenter Study

Next we will be discussing articles In the field of Nephrology

Here are the articles from Kidney International reports

Improving Blood Pressure in High-Risk Patients With CKD Using an Interdisciplinary Remote Hypertension Program

Outcomes for Patients With a Deceased Donor Kidney Offer in the New Allocation System

4 21 2025

Mon, 21 Apr 2025 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation

Fidanacogene Elaparvovec for Hemophilia B — A Multiyear Follow-up Study

Journal of American Medical Association

Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units

Annals of Internal Medicine

Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023

British Medical Journal

Firearm availability and firearm incidents: quasi-experimental analysis using start of US hunting seasons

Lancet

Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial

Journal of Clinical Oncology

Trastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer

journal of Hepatology

PNPLA3 rs738409, environmental factors and liver-related mortality in the US population

Gastroenterology

ERBB2 Comprehensive Profiling and Prognostication in Stage III Colon Cancer: Findings From PETACC8 and IDEA-France Cohorts

Clinical Gastroenterology

Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials

Rheumatology

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

Journal of Clinical Rheumatology

Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan

Circulation

Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group

Journals of the American College of Cardiology

Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women

JAMA Cardiology

Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and LesothoA Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial

Diabetes care

Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus

Neurology

Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis

Chest

Sarcoidosis Treatment Patterns in the United States

he American Journal of Respiratory and Critical Care Medicine

Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients

Kidney International reports

Randomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia

Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan

4 14 2025

Mon, 14 Apr 2025 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion

Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer

Journal of American Medical Association

Invasive Group A Streptococcal Infections in 10 US States

Annals of Internal Medicine

Insurer-Level Estimates of Revenue From Differential Coding in Medicare Advantage

British Medical Journal

Evolution of reported patient and public involvement over time in randomised controlled trials in major medical journals and in their protocols

Lancet

Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials

Cancer Journal for Clinicians

Cancer statistics for African American and Black people, 2025

Journal of Clinical Oncology

Minimal Residual Disease–Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials

journal of Hepatology

Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study

Gastroenterology

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial

Clinical Gastroenterology

Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials

Rheumatology

Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials

Journal of Clinical Rheumatology

Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies

Circulation

Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting

Journals of the American College of Cardiology

Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis

JAMA Cardiology

Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid ScreeningA Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-In-Human, Randomized Trial

Diabetes care

Diabetes Risk After Treatment for Childhood and Young Adult Cancer

Neurology

Neurodegeneration and Demyelination in the Multiple Sclerosis Spinal Cord: Clinical, Pathological, and 7T MRI Perspectives

Chest

Estimation of Expiratory Function in Infants With Passive Expiration From Total Lung Capacity

The American Journal of Respiratory and Critical Care Medicine

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts

Kidney International reports

Real-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort

Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD

4 7 2025

Mon, 07 Apr 2025 09:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours

The Genetic Architecture of Congenital Diarrhea and Enteropathy

Journal of American Medical Association

Cardiac Arrest During Long-Distance Running Races

Annals of Internal Medicine

The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial

British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension

Lancet

Pharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study

Journal of Clinical Oncology

Efficacy and Safety of Denileukin Diftitox-Cxdl, an Improved Purity Formulation of Denileukin Diftitox, in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma

journal of Hepatology

Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study

Gastroenterology

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial

Clinical Gastroenterology

Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection

Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Tria

Rheumatology

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

Journal of Clinical Rheumatology

Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies

Circulation

Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry

Journals of the American College of Cardiology

New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals

JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

Journal of Clinical Endocrinology & Metabolism

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug

Diabetes care

Diabetes Risk After Treatment for Childhood and Young Adult Cancer

Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

The American Journal of Respiratory and Critical Care Medicine

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts

Clinical Journal of American Society of Nephrology

Performance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers

Kidney International reports

Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD

3 31 2025

Mon, 31 Mar 2025 08:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes

Inebilizumab for Treatment of IgG4-Related Disease

Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

Journal of American Medical Association

Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke

A Systematic Review and Meta-Analysis

Annals of Internal Medicine

Excess Mortality Rate in Black Children Since 1950 in the United States: A 70-Year Population-Based Study of Racial Inequalities

British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis

Lancet

Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study

journal of Hepatology

Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)

Intention-to-treat outcomes of patients with hepatocellular carcinoma receiving immunotherapy before liver transplant: The multicenter VITALITY study

Immune checkpoint inhibitors exhibit significant potential in neoadjuvant therapy Gastroenterology

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations

Clinical Gastroenterology

Treatment of the Buried Bumper Syndrome: A Retrospective Multicenter Study With Inclusion of 160 Cases

Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Trial

Rheumatology

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms

Circulation

Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury

= Journals of the American College of Cardiology

Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials

JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

Journal of Clinical Endocrinology & Metabolism

Iron Status Correlates Strongly to Insulin Resistance Among US Adults: A Nationwide Population-Based Study

Diabetes care

Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 Diabetes: Results From the Diabetes Virus Detection and Intervention Trial

Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

The American Journal of Respiratory and Critical Care Medicine

Randomized Clinical Trial of the Four Supports Intervention for Surrogate Decision-Makers in Intensive Care Units

Clinical Journal of American Society of Nephrology

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

Kidney International reports

Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease

Obinutuzumab and Ofatumumab are More Effective Than Rituximab in the Treatment of Membranous Nephropathy Patients With Anti-Rituximab Antibodies

3 24 2025

Mon, 24 Mar 2025 10:20:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage

Journal of American Medical Association

Inhaled Sedation in Acute Respiratory Distress SyndromeThe SESAR Randomized Clinical Trial

Annals of Internal Medicine

Health Expenditures of Patients With Diabetes After Bariatric Surgery: Comparing Gastric Bypass and Sleeve Gastrectomy

British Medical Journal

Sonolysis during carotid endarterectomy: randomised controlled trial

Lancet

Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial

journal of Hepatology

Decreases in cT1 and liver fat content reflect treatment-induced histological improvements in MASH

Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: A post hoc analysis of the PREDESCI trial

Gastroenterology

Creeping Fat–Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease

Clinical Gastroenterology

Efficacy and Safety of Gastric Per-Oral Endoscopic Myotomy (G-POEM): A Systematic Review and Meta-Analysis

Clinical Infectious Diseases

Epidemiology, Risk Factors and Outcome of Neutropenic Enterocolitis in Onco-Hematological Patients according to Chemotherapy Regimen

Rheumatology

In‐Depth Analysis of Disease Manifestations in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides Identifies Distinct Clinical Phenotypes

Journal of Clinical Rheumatology

Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease

Circulation

Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions

Journals of the American College of Cardiology

Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis

JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

Journal of Clinical Endocrinology & Metabolism

Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome

Neurology

Association of Social Determinants of Health With Genetic Test Request and Completion Rates in Children With Neurologic Disorders

Chest

Isolation of Genetically Distinct Strains Within the Same Species During Treatment of Mycobacterium Avium Complex Pulmonary Disease

The American Journal of Respiratory and Critical Care Medicine

Timing of Extubation in Adult Patients with Acute Brain Injury

Clinical Journal of American Society of Nephrology

Biomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors

Kidney International reports

GFR is a Key Determinant of Red Blood Cell Survival in Anemia Associated With Progressive CKD

Blood Pressure Goals and Outcomes in Kidney Transplant Recipients in an Analysis of the Collaborative Transplant Study

3 17 2025

Mon, 17 Mar 2025 08:10:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage

Journal of American Medical Association

Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck

A Randomized Clinical Trial

Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma

The DIPPER Randomized Clinical Trial

British Medical Journal

Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050

Lancet

Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

journal of Hepatology

Frailty and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases

Non-invasive assessment of severe liver fibrosis in patients with Fontan-associated liver disease: The VALDIG-EASL FONLIVER cohort

Gastroenterology

Creeping Fat–Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease

Clinical Gastroenterology

Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection

Rheumatology

Changes in Long‐Term Glucocorticoid Use Among Older Adults After New Diagnosis of Late‐Onset Rheumatoid Arthritis

Journal of Clinical Rheumatology

Risk of Malignancy Related to Ixekizumab in Patients With Psoriatic Arthritis or Axial Spondyloarthropathy: Systematic Review and Meta-analysis

Circulation

Long-Term Efficacy and Safety of Acoramidis in ATTR-CM: Initial Report From the Open-Label Extension of the ATTRibute-CM Trial

Journals of the American College of Cardiology

Predictors of Outcomes of Reintervention After Transcatheter Aortic Valve Replacement

Journal of Clinical Endocrinology & Metabolism

Weight-Specific Grip Strength as a Novel Indicator Associated With Cardiometabolic Risk in Children: The EMSNGS Study

Diabetes care

The Association Between Cost-Related Insulin Rationing and Health Care Utilization in U.S. Adults With Diabetes

The American Journal of Respiratory and Critical Care Medicine

Impact of Fluid Balance on the Development of Lung Injury

Clinical Journal of American Society of Nephrology

Perspectives and Experiences of Patients with AKI: A Systematic Review

Kidney International reports

Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Influence of Individual- and Area-Level Social Determinants of Health on Likelihood of Living Versus Deceased Donor Kidney Transplantation

3 10 2025

Mon, 10 Mar 2025 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis

Tirzepatide for Obesity Treatment and Diabetes Prevention

Remibrutinib in Chronic Spontaneous Urticaria

Journal of American Medical Association

Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial

Question Does the use of coronary artery calcium (CAC) scoring in intermediate-risk patients with a family history of premature coronary artery disease (CAD) lead to less progression of coronary atheroma in follow-up?

Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease

A Randomized Clinical Trial

Annals of Internal Medicine

Molecular Imaging Versus Adrenal Vein Sampling for the Detection of Surgically Curable Primary Aldosteronism: A Prospective Within-Patient Trial

British Medical Journal

Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and Lancet

A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study

journal of Hepatology

Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity

Hepatocyte aquaporin 8-mediated water transport facilitates bile dilution and prevents gallstone formation in mice

Gastroenterology

A High-Resolution Microendoscope Improves Esophageal Cancer Screening and Surveillance: Implications for Underserved Global Settings Based on an International Randomized Controlled Trial

Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

Clinical Infectious Diseases

Audit and Feedback Interventions for Antibiotic Prescribing in Primary Care: A Systematic Review and Meta-analysis

Rheumatology

RheuMetric Physician 0 to 10 Estimates of Inflammation, Damage, and Patient Distress at Initial Versus Follow-Up Visits in Contemporary Rheumatology Care

Journal of Clinical Rheumatology

Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease

Circulation

Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial)

Journals of the American College of Cardiology

Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD

JAMA Cardiology

Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF ModelA Secondary Analysis of FINEARTS-HF

Journal of Clinical Endocrinology & Metabolism

Comparison of Cumulative Live Birth Rates Between Progestin and GnRH Analogues in Preimplantation Genetic Testing Cycles

Diabetes care

Effects of Adopting Preventive Drug Lists on Medication Costs and Disparities by Income Over 2 Years: A Natural Experiment for Translation in Diabetes (NEXT-D) Study

The American Journal of Respiratory and Critical Care Medicine

Air Hunger Far Exceeds Dyspnea Sense of Effort during Mechanical Ventilation and a Weaning Trial

Kidney International reports

Pharmacokinetics and Side Effects of Δ9-Tetrahydrocannabinol and Cannabidiol in Patients with Different Stages of CKD

Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen

3 3 2025

Mon, 03 Mar 2025 10:50:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans

Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma

Oral Infigratinib Therapy in Children with Achondroplasia

Journal of American Medical Association

First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer: The GEMSTONE-303 Randomized Clinical Trial

Medicaid Spending and Health-Related Social Needs in the North Carolina Healthy Opportunities Pilots Program

Annals of Internal Medicine

Glucagon-Like Peptide-1 Receptor Agonists and Risk for Depression in Older Adults With Type 2 Diabetes: A Target Trial Emulation Study

British Medical Journal

Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study

Lancet

Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial

Journal of Clinical Oncology

Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy

journal of Hepatology

Variation in intention-to-treat survival by MELD subtypes: All models created for end-stage liver disease are not equal

Clinical Gastroenterology

Meta-Analysis of Endoscopic Full-Thickness Resection Versus Endoscopic Submucosal Dissection for Complex Colorectal Lesions

Rheumatology

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficileInfection

Journal of Clinical Rheumatology

Circulation

Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations

Journals of the American College of Cardiology

Intensive Lifestyle Intervention, Cardiac Biomarkers, and Cardiovascular Outcomes in Diabetes: Look AHEAD Cardiac Biomarker Ancillary Study

JAMA Cardiology

Interpreting Population Mean Treatment Effects in the Kansas City Cardiomyopathy QuestionnaireA Patient-Level Meta-Analysis

Journal of Clinical Endocrinology & Metabolism

Clinical and Biochemical Data for the Diagnosis of Endogenous Hypercortisolism: The “Cushingomic” Approach

Neurology

Utility of Progression Independent of Relapse Activity as a Trial Outcome in Relapsing-Remitting Multiple Sclerosis

Chest

The Responsiveness of Exercise Tests in COPD

A Randomized Controlled Trial

The American Journal of Respiratory and Critical Care Medicine

Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial

Clinical Journal of American Society of Nephrology

Efficacy and Safety of Admilparant, an LPA1 Antagonist, in Pulmonary Fibrosis: A Phase 2 Randomized Clinical Trial

Kidney International reports

Impact of Different CKD Definitions on Long-Term Renal Function and Mortality in a Population-Based Cohort Study

2 24 2025

Mon, 24 Feb 2025 10:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia

Fixed-Duration Acalabrutinib Combinations in Untreated Chronic Lymphocytic Leukemia

Microvascular Inflammation of Kidney Allografts and Clinical Outcomes

Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease

Journal of American Medical Association

Emergency Clinician Buprenorphine Initiation, Subsequent Prescriptions, and Continuous Prescriptions

Illicit Substance Use and Treatment Access Among Adults Experiencing Homelessness

Annals of Internal Medicine

Effects of Noise and Public Setting on Blood Pressure Readings: A Randomized Crossover Trial

The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation: A Retrospective Cohort Study

British Medical Journal

Stroke and myocardial infarction with contemporary hormonal contraception: real-world, nationwide, prospective cohort study

Lancet

Epidemiological and clinical features of mpox during the clade Ib outbreak in South Kivu, Democratic Republic of the Congo: a prospective cohort study

journal of Hepatology

Identifying the optimal measurement timing and hemodynamic targets of portal pressure gradient after TIPS in patients with cirrhosis and variceal bleeding

Gastroenterology

Safety and Tolerability of CP101, a Full-Spectrum, Oral Microbiome Therapeutic for the Prevention of Recurrent Clostridioides difficile Infection: A Phase 2 Randomized Controlled Trial

Clinical Gastroenterology

Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States

Clinical Infectious Diseases

PUNCH CD3-OLS: A Phase 3 Prospective Observational Cohort Study to Evaluate the Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA) in Adults With Recurrent Clostridioides difficile Infection

Arthritis and Rheumatology

Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis

Circulation

Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

Journals of the American College of Cardiology

Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease

JAMA Cardiology

Coronary Revascularization Guided With Fractional Flow Reserve or Instantaneous Wave-Free RatioA 5-Year Follow-Up of the DEFINE FLAIR Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes

Diabetes care

Intensive Glucose Lowering and Its Effects on Vascular Events and Death According to Age at Diagnosis and Duration of Diabetes: The ADVANCE Trial

Neurology

Effects of COVID-19 Infection on Symptom Severity and Disability in Multiple Sclerosis

Infections, including infection with SARS-CoV-2 (COVID-19), could alter the course of multiple sclerosis (MS). Previous studies assessing the Chest

longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD

The American Journal of Respiratory and Critical Care Medicine

Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS

Clinical Journal of American Society of Nephrology

Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial

Kidney International reports

Randomized Trial of Dietary Acid Reduction and Acid-Base Status of Patients With CKD and Normal Estimated GFR

CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology

2 17 2025

Mon, 17 Feb 2025 10:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Colchicine in Acute Myocardial Infarction

Routine Spironolactone in Acute Myocardial Infarction

Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors

Evolving Epidemiology of Mpox in Africa in 2024

Journal of American Medical Association

US Abortion Bans and Fertility

Annals of Internal Medicine

Effectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up: A Target Trial Emulation

British Medical Journal

Stroke and myocardial infarction with contemporary hormonal contraception: real-world, nationwide, prospective cohort study

Lancet

Life expectancy losses in the Gaza Strip during the period October, 2023, to September, 2024

Journal of Clinical Oncology

Trastuzumab Duocarmazine in Pretreated Human Epidermal Growth Factor Receptor 2–Positive Advanced or Metastatic Breast Cancer: An Open-Label, Randomized, Phase III Trial (TULIP)

journal of Hepatology

PegIFN alpha-2a reduces relapse in HBeAg-negative patients after nucleo(s)tide analogue cessation: A randomized-controlled trial

Gastroenterology

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7–Blocking Therapy in Inflammatory Bowel Disease

Clinical Gastroenterology

Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant

Clinical Infectious Diseases

Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureusBacteremia or Endocarditis: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials

Arthritis and Rheumatology

Social Connections in Older Adults With Systemic Lupus Erythematosus: Patient Perspectives

Circulation

A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia

Journals of the American College of Cardiology

Higher Aircraft Noise Exposure Is Linked to Worse Heart Structure and Function by Cardiovascular MRI

JAMA Cardiology

Cerebral Embolic Protection by Geographic RegionA Post Hoc Analysis of the PROTECTED TAVR Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma

Diabetes care

Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

Neurology

Chemotherapy-Related Cognitive Impairment and Changes in Neural Network Dynamics: A Systematic Review

Chest

Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization

A Multicenter, Retrospective Study

The American Journal of Respiratory and Critical Care Medicine

Effect of Triple Therapy on Cardiovascular and Severe Cardiopulmonary Events in Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of a Randomized, Double-Blind, Phase 3 Clinical Trial (ETHOS)

Clinical Journal of American Society of Nephrology

Kidney International reports

Cost-Effectiveness of Clinical Decision Support to Improve CKD Outcomes Among First Nations Australians

2 10 2025

Mon, 10 Feb 2025 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy

Atrasentan in Patients with IgA Nephropathy

Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer

Journal of American Medical Association

Simvastatin and Rifaximin in Decompensated Cirrhosis

A Randomized Clinical Trial

Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes

A Network Meta-Analysis

Annals of Internal Medicine

Effectiveness and Cost-Effectiveness of Expanded Targeted Testing and Treatment of Latent Tuberculosis Infection Among the Medicare Population in 2022

British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for IVF treatment

Lancet

Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis

Journal of Clinical Oncology

OPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer

Hepatology

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Gastroenterology

Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels

Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

Clinical Infectious Diseases

Antibiotic Prescribing for Respiratory Tract Infections in Urgent Care: A Comparison of In-Person and Virtual Settings

Rheumatology

Use of 18F-fluorodeoxyglucose Positron Emission Tomography to Monitor Disease Activity in Patients With Giant Cell Arteritis on Tocilizumab

Journal of Clinical Rheumatology

Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

Circulation

Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial

Journals of the American College of Cardiology

Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study

JAMA Cardiology

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial

Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle

Diabetes care

Large Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Glucose-Lowering Medication Under Conditions of Clinical Uncertainty

Neurology

Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial

Chest

A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity

A Randomized Controlled Study

The American Journal of Respiratory and Critical Care Medicine

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

Clinical Journal of American Society of Nephrology

Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study

Kidney International reports

Implementation of a Kidney Genetic Service Into the Diagnostic Pathway for Patients With Chronic Kidney Disease in Canada

clinical utility, strategies to reduce the time from CKD diagnosis to genetics assessment are needed.

2 3 2025

Mon, 03 Feb 2025 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

Continuation versus Interruption of Oral Anticoagulation during TAVI

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

CRISPR-Based Therapy for Hereditary Angioedema

Journal of American Medical Association

Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers

Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers

The IN-PEACE Randomized Clinical Trial

Annals of Internal Medicine

The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation

British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial

Lancet

Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland

Journal of Clinical Oncology

Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study

journal of Hepatology

Patient-reported outcomes in chronic hepatitis delta: An exploratory analysis of the phase III MYR301 trial of bulevirtide

outcome following liver transplantation of patients with ACLF grade 3

Gastroenterology

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells

Clinical Gastroenterology

Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States

Do Patients With NASH-related Cirrhosis Have Better Overall Survival Compared With Other Etiologies of Cirrhosis? A Population-based Study

Rheumatology

Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease

Circulation

Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial

Journals of the American College of Cardiology

Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators

JAMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

Journal of Clinical Endocrinology & Metabolism

Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study

Diabetes care

Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial

Chest

Longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD

The American Journal of Respiratory and Critical Care Medicine

Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis

Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis

Cost-Effectiveness of Empagliflozin in CKD with or without Albuminuria

Kidney International reports

Randomized Trial Demonstrating No Translocation of Intact Intestinal Bacteria During Hemodialysis or Hemodiafiltration

1 27 2025

Mon, 27 Jan 2025 10:40:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest

Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation

Journal of American Medical Association

Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial

Question Is transanal total mesorectal excision (TME) noninferior to laparoscopic Annals of Internal Medicine

Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities

Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine

British Medical Journal

Dapagliflozin plus calorie restriction for remission of type 2 diabetes

Lancet

Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study

Journal of Clinical Oncology

Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study

journal of Hepatology

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy

Gastroenterology

Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction

Clinical Gastroenterology

Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant

Association Between Different Types of Physical Activity and Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES

Journal of Clinical Rheumatology

Preliminary Evaluation for the Development of a Scoring System to Predict Homozygous M694V Genotype in Familial Mediterranean Fever Patients: A Single-Center Study

Circulation

A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand

Journals of the American College of Cardiology

Optimal Strategy for Complete Revascularization in ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis

JAMA Cardiology

Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population

Journal of Clinical Endocrinology & Metabolism

Personalized Medicine in Acromegaly: The ACROFAST Study

Diabetes care

Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study

Chest

Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis

The American Journal of Respiratory and Critical Care Medicine

Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations

Clinical Journal of American Society of Nephrology

Fracture in Association with Anticoagulant Therapy in Patients with CKD and Atrial Fibrillation

Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus

Kidney International reports

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients

1 20 2025

Mon, 20 Jan 2025 09:20:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis

APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans

Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age

Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer

Journal of American Medical Association

Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial

Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial

Annals of Internal Medicine

Inequities in Distance to Lung Cancer Screening Programs

British Medical Journal

Time to nursing home admission and death in people with dementia

Lancet

Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Journal of Clinical Oncology

Association of Participation in Medicare's Oncology Care Model With Spending, Utilization, and Quality Outcomes Among Commercially Insured and Medicare Advantage Members

journal of Hepatology

Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

Gastroenterology

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis

Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

Meta-Analysis of Endoscopic Full-Thickness Resection Versus Endoscopic Submucosal Dissection for Complex Colorectal Lesions

Rheumatology

Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA

Journal of Clinical Rheumatology

Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

Circulation

Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions

Journals of the American College of Cardiology

Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial

Aspirin and Hemocompatibility After LVAD Implantation in Patients With Atherosclerotic Vascular Disease

A Secondary Analysis From the ARIES-HM3 Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

Diabetes care

Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial

Here are the articles from Chest

Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization

Here are the articles from The American Journal of Respiratory and Critical Care Medicine

Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study.

Clinical Journal of American Society of Nephrology

Surrogate End Points in Apolipoprotein L1–Associated Kidney Disease: Evaluation in Three Cohorts

Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study

Kidney International reports

Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

1 13 2025

Mon, 13 Jan 2025 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Transcatheter Valve Replacement in Severe Tricuspid Regurgitation

Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk

Talquetamab plus Teclistamab in Relapsed or Refractory Multiple Myeloma

Clearance of Driver Mutations after Transplantation for Myelofibrosis

A Comparison of Peripherally Inserted Central Catheter Materials

Journal of American Medical Association

Changes in Patient Care Experience After Private Equity Acquisition of US Hospitals

Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes

Annals of Internal Medicine

Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis

Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine

British Medical Journal

Time to nursing home admission and death in people with dementia

Lancet

Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial

Cancer Journal for Clinicians

Breast cancer statistics 2024

Journal of Clinical Oncology

Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma

journal of Hepatology

Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Gastroenterology

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis

Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

Clinical Infectious Diseases

Epidemiology and Prognostic Factors Associated With Mold-Positive Blood Cultures: 10-Year Data From a French Prospective Surveillance Program (2012–2022)

Rheumatology

Frequency of Spondyloarthritis Symptoms Among U.S. Patients with Inflammatory Bowel Disease: A Cross‐sectional Multi‐Center Study

Circulation

Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions

Journals of the American College of Cardiology

Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial

JAMA Cardiology

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

Diabetes care

Trends and Inequalities in Diabetes-Related Complications Among U.S. Adults, 2000–2020

Neurology

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study

Chest

A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity

The American Journal of Respiratory and Critical Care Medicine

Association of Dose of Inhaled Corticosteroids and Frequency of Adverse Events

Clinical Journal of American Society of Nephrology

Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD

Kidney International reports

Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

1 6 2025

Mon, 06 Jan 2025 11:05:00 +0000

Happy New year to all the listeners.

Thank you for listening in 2024 and hope to see you here weekly in 2025.

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma

Asundexian versus Apixaban in Patients with Atrial Fibrillation

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma

Journal of American Medical Association

Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth

Annals of Internal Medicine

Implementation of Billing for Patient Portal Messages as E-Visits in a Large Integrated Health System

British Medical Journal

Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease

Lancet

Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis

journal of Hepatology

Metabolic phenotyping of patients with advanced chronic liver disease for better characterization of cirrhosis regression

Gastroenterology

Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

Clinical Infectious Diseases

Clinical characterisation and outcomes of human clade IIb mpox virus disease

Circulation

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

Journals of the American College of Cardiology

Using Electrocardiogram to Assess Diastolic Function and Prognosis in Mitral Regurgitation

AMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

Neurology

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study

Chest

Exacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD

Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations

The American Journal of Respiratory and Critical Care Medicine

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial

Clinical Journal of American Society of Nephrology

Benefits and Harms of Coronary Revascularization in Non–Dialysis-Dependent Chronic Kidney Disease and Ischemic Heart Disease: A Systematic Review and Meta-Analysis

Kidney International reports

Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories

12 30 2024

Mon, 30 Dec 2024 10:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Ponsegromab for the Treatment of Cancer Cachexia

Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam

Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination

Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype

Journal of American Medical Association

2024 Update of the RECOVER-Adult Long COVID Research Index

Annals of Internal Medicine

iImpaired Wnt/Planar Cell Polarity Signaling in Yellow Nail Syndrome

British Medical Journal

Christmas 2024: Age against the machine—susceptibility of large language models to cognitive impairment

Lancet

Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Journal of Clinical Oncology

Bladder-Preserving Trimodality Treatment for High-Grade T1 Bladder Cancer: Results From Phase II Protocol NRG Oncology/RTOG 0926

journal of Hepatology

Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection

Gastroenterology

Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases

Clinical Infectious Diseases

Impact of Intrapartum Azithromycin on the Carriage and Antibiotic Resistance of Escherichia coli and Klebsiella pneumoniae in Mothers and Their Newborns

Rheumatology

Achieving Medication‐Free Remission in Patients With Juvenile Dermatomyositis

Circulation

Therapeutic Effects of Heart Failure Medical Therapies on Standardized Kidney Outcomes: Comprehensive Individual Participant–Level Analysis of 6 Randomized Clinical Trials

Journals of the American College of Cardiology

Hypertensive Disorders of Pregnancy Increase the Risk for Myocardial Infarction: A Population-Based Study

Diabetes care

Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control

Chest

Occupational Exposure to Charcoal Smoke and Dust, a Major Risk Factor for COPD

Dexmedetomidine for Reducing Mortality in Patients With Septic Shock

The American Journal of Respiratory and Critical Care Medicine

Concordance and Prognostic Relevance of Different Definitions of Systemic Sclerosis Interstitial Lung Disease Progression

Clinical Journal of American Society of Nephrology

Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction

Kidney International reports

Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories

12 23 2024

Mon, 23 Dec 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Ponsegromab for the Treatment of Cancer Cachexia

Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam

Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination

Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype

Journal of American Medical Association

2024 Update of the RECOVER-Adult Long COVID Research Index

Annals of Internal Medicine

Risk for Financial Precarity From Hospitalization: Implications for Targeting Financial Assistance in Medicare

Lancet

Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

Journal of Clinical Oncology

Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results

Gastroenterology

An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk

Journal of Clinical Rheumatology

Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid Arthritis

Circulation

NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study

Journals of the American College of Cardiology

2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis: A Nationwide Registry Study

JAMA Cardiology

Amiodarone or Implantable Cardioverter-Defibrillator in Chagas CardiomyopathyThe CHAGASICS Randomized Clinical Trial

Diabetes care

Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study

Chest

Severity of Inhalation Injury and Risk of Nosocomial Pneumonia

Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation

The American Journal of Respiratory and Critical Care Medicine

Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome

Clinical Journal of American Society of Nephrology

Breast and Prostate Cancer Screening by Life Expectancy in Patients with Kidney Failure on Dialysis

Kidney International reports

Pilot Trial of Hydroxychloroquine as Add-On Therapy in Patients With Membranous Nephropathy

Urine Protein-to-Creatinine Ratio Remains Informative Despite Nonsteady State Serum Creatinine During Acute Kidney Injury

12 16 2024

Mon, 16 Dec 2024 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment

Bedaquiline Monotherapy for Multibacillary Leprosy

Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy

Journal of American Medical Association

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards

Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial

Annals of Internal Medicine

Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank

British Medical Journal

Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial

Lancet

National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050

Journal of Clinical Oncology

Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab

Hepatology

Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease

Gastroenterology

Exon-Skipping–Based Subtyping of Colorectal Cancers

Rheumatology

Revisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinated Peptide/Protein Antibodies

Journal of Clinical Rheumatology

Periprosthetic Joint Infection in Patients With Inflammatory Arthritis: Optimal Tests to Differentiate From Flares

Circulation

Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II

Journals of the American College of Cardiology

Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip: Insights From RESHAPE-HF2

Endocrinology

Diabetes care

Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Associated With Reduced Hospitalization for Acute Diabetes Events and Cardiovascular Complications in Adults With Type 1 Diabetes

Chest

Impact of Dyspnea on Adults With Respiratory Symptoms Without a Defined Diagnosis

Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock

The American Journal of Respiratory and Critical Care Medicine

Application of the European Respiratory Society/American Thoracic Society Spirometry Standards and Race-Neutral Equations in the COPDGene Study

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Bioimpedance-Guided Fluid Removal in Continuous KRT: The VENUS Randomized Clinical Trial

Kidney International reports

Anti Phospholipase A2 Receptor 1 Antibodies and Membranous Nephropathy Recurrence After Kidney Transplantation

Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy

12 9 2024

Mon, 09 Dec 2024 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease

Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B

Trastuzumab Deruxtecan after Endocrine Therapy in Metastatic Breast Cancer

Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer

Journal of American Medical Association

HepB-CpG vs HepB-Alum Vaccine in People With HIV and Prior Vaccine NonresponseQuestion Does vaccination with a hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG vaccine) improve hepatitis B virus (HBV) seroprotection in people with HIV and nonresponse to prior hepatitis B vaccine?

Message Reminders to Improve Adherence to Chronic Cardiovascular Medications

Annals of Internal Medicine

A Framework for Considering the Value of Race and Ethnicity in Estimating Disease Risk

British Medical Journal

Chocolate intake and risk of type 2 diabetes: prospective cohort studies

Lancet

Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial

Journal of Clinical Oncology

Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, EGFR–Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer

journal of Hepatology

Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer

Gastroenterology

Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response

Rheumatology

Axial Spondyloarthritis in Black Americans: An Observational Study From Five Centers in Shelby County, Tennessee

Journal of Clinical Rheumatology

Anticoagulant Treatment May Decrease the Relapse Rate of Pulmonary Arterial Involvement in Behçet’s Disease

Circulation

Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial

Journals of the American College of Cardiology

Major Bleeding and Mortality After Revascularization of Left Main Disease

Diabetes care

Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study

American Journal of Respiratory and Critical Care Medicine

Severity of Airflow Obstruction Based on FEV1/FVC Versus FEV1 Percent

Kidney International reports

Prognosis for Type 1 Diabetes with Diabetic Nephropathy between 2000 and 2020 - Changes in Kidney Function Decline Over Time and Development of Cardiovascular Disease, Kidney Failure, and Mortality

Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population

12 2 2024

Mon, 02 Dec 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer

Journal of American Medical Association

Association of Severe Maternal Morbidity With Subsequent Birth

Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery

Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation

The Tri.Fr Randomized Clinical Trial

Annals of Internal Medicine

Association of Work Control With Burnout and Career Intentions Among U.S. Physicians: A Multi-Institution Stud

British Medical Journal

Contemporary menopausal hormone therapy and risk of cardiovascular disease

Lancet

Cancer Journal for Clinicians

A phase 2 study of a brachyury-targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma

Journal of Clinical Oncology

Prospective Study of Supplemental Screening With Contrast-Enhanced Mammography in Women With Elevated Risk of Breast Cancer: Results of the Prevalence Round

journal of Hepatology

Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis

Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma

Gastroenterology

Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease

Clinical Gastroenterology

Updated Reference Intervals for Alanine Aminotransferase in a Metabolically and Histologically Normal Population

Clinical Infectious Diseases

The Use of Long-term Antibiotics for Suppression of Bacterial Infections

Rheumatology

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic

Journal of Clinical Rheumatology

Circulation

ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension

Journals of the American College of Cardiology

Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial

JAMA Cardiology

Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve ImplantationThe ACE-PROTAVI Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study

Diabetes care

Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Neurology

SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes

Chest

Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD

The American Journal of Respiratory and Critical Care Medicine

Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study

Clinical Journal of American Society of Nephrology

Acute Myocardial Infarction and Chronic Kidney Disease: A Nationwide Cohort Study on Management and Outcomes from 2010 to 2022

Kidney International reports

Randomized Trial of Patiromer on Efficacy to Reduce Episodic Hyperkalemia in Patients with ESKD Treated With Hemodialysis

11 25 2024

Mon, 25 Nov 2024 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

in New England Journal of Medicine

Nationwide, Couple-Based Genetic Carrier Screening

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

Journal of American Medical Association

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial

Annals of Internal Medicine

The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease

British Medical Journal

Nurse and doctor turnover and patient outcomes in NHS acute trusts in England

Lancet

Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan

Cancer Journal for Clinicians

Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma

Journal of Clinical Oncology

Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial

Hepatology

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Gastroenterology

Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

Clinical Gastroenterology

Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

Clinical Infectious Diseases

Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022

Rheumatology

Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

Journal of Clinical Rheumatology

Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India

Circulation

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

Journals of the American College of Cardiology

Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation

JAMA Cardiology

Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes

Diabetes care

Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019

Neurology

Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy

Chest

Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk

A Longitudinal Study

The American Journal of Respiratory and Critical Care Medicine

Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)

Clinical Journal of American Society of Nephrology

Physical Function and Mortality in Older Adults with Chronic Kidney Disease

Kidney International reports

Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT

11 18 2024

Mon, 18 Nov 2024 12:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer

Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation

Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation

Preoperative Chemoradiotherapy for Resectable Gastric Cancer

Journal of American Medical Association

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial

Tenofovir and Hepatitis B Virus Transmission During Pregnancy

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

Annals of Internal Medicine

Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort

British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

Malnutrition in infants aged 6-23 months in China’s poorest rural counties from 2016 to 2021

Lancet

Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study

Cancer Journal for Clinicians

Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer

Journal of Clinical Oncology

Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial

Hepatology

CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals

Gastroenterology

The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018

Clinical Gastroenterology

The Efficacy of Real-time Computer-aided Detection of Colonic Neoplasia in Community Practice: A Pragmatic Randomized Controlled Trial

Clinical Infectious Diseases

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study

Rheumatology

Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study

Journal of Clinical Rheumatology

Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

Circulation

Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment–Elevation Myocardial Infarction: An Individual Patient Meta-Analysis

Journals of the American College of Cardiology

Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy

JAMA Cardiology

Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial InfarctionThe PULSE-MI Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence

Diabetes care

Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration

Neurology

Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach

Chest

Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis

The American Journal of Respiratory and Critical Care Medicine

Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial

Clinical Journal of American Society of Nephrology

Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease: Results from the EQUAL Study

Kidney International reports

IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens

11 7 2024

Mon, 11 Nov 2024 09:05:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Invasive Treatment Strategy for Older Patients with Myocardial Infarction

Randomized Trial of Very Early Medication Abortion

Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma

Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

Journal of American Medical Association

Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries

The SAFE-IVC Study

A Digital Health Behavior Intervention to Prevent Childhood Obesity

The Greenlight Plus Randomized Clinical Trial

Annals of Internal Medicine

Ensuring Safe Practice by Late Career Physicians: Institutional Policies and Implementation Experiences

British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

Lancet

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Cancer Journal for Clinicians

Epidemiology, treatment patterns, and clinical outcomes in de novo oligometastatic hormone-sensitive prostate cancer

Journal of Clinical Oncology

Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial

journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

Gastroenterology

Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

Clinical Gastroenterology

Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

Clinical Infectious Diseases

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

Rheumatology

Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

Journal of Clinical Rheumatology

Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

Circulation

Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States

Journals of the American College of Cardiology

Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

Diabetes care

Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes

Neurology

Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

Chest

Primary Ciliary Dyskinesia in Adult Bronchiectasis

American Journal of Respiratory and Critical Care Medicine

Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma

Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults

Kidney International reports

Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy

11 4 2024

Mon, 04 Nov 2024 11:15:00 +0000

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New England Journal of Medicine

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis

Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis

from Journal of American Medical Association

Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis

The EVOLVED Randomized Clinical Trial

Annals of Internal Medicine

Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer

Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study

British Medical Journal

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies

Lancet

The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial

Journal of Clinical Oncology

Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)

journal of Hepatology

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

Gastroenterology

A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis

Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)

Clinical Infectious Diseases

Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections

Abstract

Rheumatology

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center

Circulation

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing

Journals of the American College of Cardiology

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis

JAMA Cardiology

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

Diabetes care

Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes

The American Journal of Respiratory and Critical Care Medicine

The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome

Rationale: A U-shaped relationship should exist between lung volume and Kidney International reports

Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients

A Survey on End-of-Life Contemplation Among Patients on Dialysis

10 28 2024

Mon, 28 Oct 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC

Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture

Journal of American Medical Association

Dialysis Facility Staffing Ratios and Kidney Transplant Access Among Adolescents and Young Adults

Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions

Annals of Internal Medicine

Colorectal Cancer Screening Completion and Yield in Patients Aged 45 to 50 Years: An Observational Study

British Medical Journal

Association of holidays and the day of the week with suicide risk: multicounty, two stage, time series study

Lancet

Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial

Journal of Clinical Oncology

Social Characteristics and Adherence to Adjuvant Endocrine Therapy in Premenopausal Women With Breast Cancer

journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

Gastroenterology

Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis

Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension

Clinical Gastroenterology

Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

Clinical Infectious Diseases

Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults

Journal of Clinical Rheumatology

Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

Circulation

Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing

Journals of the American College of Cardiology

Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study

Diabetes care

Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin

Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial

Neurology

Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

Chest

Characteristics of Adults With Severe Asthma in Childhood

A 60-Year Follow-Up Study

The American Journal of Respiratory and Critical Care Medicine

Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease

Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

Kidney International reports

Elevated Ambient Temperature Associated With Increased Cardiovascular Disease–Risk Among Patients on Hemodialysis

Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis

10 21 2024

Mon, 21 Oct 2024 09:35:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma

Safety of Kidney Transplantation from Donors with HIV

A Modular Communicative Leadless Pacing–Defibrillator System

Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer

Journal of American Medical Association

Testing and Evaluation of Health Care Applications of Large Language Models

A Systematic Review

Annals of Internal Medicine

School Mask Mandates and COVID-19: The Challenge of Using Difference-in-Differences Analysis of Observational Data to Estimate the Effectiveness of a Public Health Intervention

British Medical Journal

Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study

Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries

Lancet

Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials

Journal of Clinical Oncology

Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies

journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

Gastroenterology

Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY)

Prognostic Factors for Early Recurrence After Resection of Pancreatic Cancer: A Systematic Review and Meta-Analysis

Clinical Infectious Diseases

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

Rheumatology

Leveraging Habits to Improve Adherence to Gout Medications: A Qualitative Study

Journal of Clinical Rheumatology

Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

Circulation

Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation

Journals of the American College of Cardiology

Bivalirudin vs Heparin Anticoagulation in STEMI: Confirmation of the BRIGHT-4 Results

JAMA Cardiology

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

Diabetes care

Discrepancy Between Genetically Predicted and Observed BMI Predicts Incident Type 2 Diabetes

Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes

Neurology

Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort

Chest

Characteristics of Adults With Severe Asthma in Childhood

The American Journal of Respiratory and Critical Care Medicine

Impact of Using Pre- and Postbronchodilator Spirometry Reference Values in a Chinese Population

Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

Kidney International reports

Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor

Losing Much More Than a Transplant: A Qualitative Study of Kidney Transplant Recipients’ Experiences of Graft Failure

10 14 2024

Mon, 14 Oct 2024 10:00:00 +0000

New England Journal of Medicine

Beta-Blocker Interruption or Continuation after Myocardial Infarction

Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy

Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy

Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer

Journal of American Medical Association

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial

Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial

Annals of Internal Medicine

Pain Reduction With Oral Methotrexate in Knee Osteoarthritis

British Medical Journal

Rainfall events and daily mortality across 645 global locations

Lancet

Tivozanib plus nivolumab versus tivozanib monotherapy in patients with renal cell carcinoma following an immune checkpoint inhibitor: results of the phase 3 TiNivo-2 Study

Effects of oral sepiapterin on blood Phe concentration in a broad range of patients with phenylketonuria (APHENITY): results of an international, phase 3, randomised, double-blind, placebo-controlled trial

Journal of Clinical Oncology

Post-Transplant Cyclophosphamide–Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors

Gastroenterology

WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors

Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer

Journal of Clinical Rheumatology

Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

Circulation

Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension

Journals of the American College of Cardiology

Minimum National Prevalence of Diagnosed Atrial Fibrillation Inferred From California Acute Care Facilities

Diabetes care

Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries

Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study

The American Journal of Respiratory and Critical Care Medicine

Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults

Kidney International reports

Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK)

Bringing a Systems Approach to Living Donor Kidney Transplantation

10 7 2024

Mon, 07 Oct 2024 08:50:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity

Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer

Journal of American Medical Association

Screening for Helicobacter pylori to Prevent Gastric Cancer

Assessment of Antitachycardia Pacing in Primary Prevention Patients

The APPRAISE ATP Randomized Clinical Trial

Annals of Internal Medicine

Time-Restricted Eating in Adults With Metabolic Syndrome: A Randomized Controlled Trial

British Medical Journal

Model of integrated mental health video consultations for people with depression or anxiety in primary care

Lancet

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

journal of Hepatology

Prospective validation of the EASL management algorithm for acute kidney injury in cirrhosis

Gastroenterology

Comparison of Vonoprazan Versus Intravenous Proton Pump Inhibitor for Prevention of High-Risk Peptic Ulcers Rebleeding After Successful Endoscopic Hemostasis: A Multicenter Randomized Noninferiority Trial

Clinical Gastroenterology

Representation of Racial Minorities in the United States Colonoscopy Surveillance Interval Guidelines

Clinical Infectious Diseases

Make Modern Microbiology Matter More in the 2023 European Society of Cardiology Guidelines for the Management of Infective Endocarditis

HIV, HIV-Specific Factors, and Myocardial Disease in Women

Arthritis and Rheumatology

Expanded CD8+CD38+ T Cell Population in Patients With Systemic Lupus Erythematosus Is Linked to Increased Infection Rates: A Prospective Study

Circulation

Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest

Journals of the American College of Cardiology

Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion

JAMA Cardiology

Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk

Journal of Clinical Endocrinology & Metabolism

Contralateral Suppression in Adrenal Venous Sampling Predicts Clinical and Biochemical Outcome in Primary Aldosteronism

Diabetes care

Long-term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers With Diabetes During Pregnancy: A Large, Population-Based Cohort Study in Ontario, Canada

Neurology

Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Chest

Barriers and Facilitators of Surrogates Providing Consent for Critically Ill Patients in Clinical Trials

The American Journal of Respiratory and Critical Care Medicine

Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis

Clinical Journal of American Society of Nephrology

A National Survey of Pregnancy and Parenthood among Nephrology Trainees: A Focus on Nephrology Fellowship

Kidney International reports

APOL1 High-Risk Genotype is Not Associated With New or Worsening of Proteinuria or Kidney Function Decline Following COVID-19 Vaccination

9 30 2024

Mon, 30 Sep 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Results after Four Years of Screening for Prostate Cancer with PSA and MRI

Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection

Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B

Journal of American Medical Association

Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial

Thrombectomy for Stroke With Large Infarct on Noncontrast CT

The TESLA Randomized Clinical Trial

Annals of Internal Medicine

Severe Maternal and Neonatal Morbidity Among Gestational Carriers: A Cohort Study

British Medical Journal

Model of integrated mental health video consultations for people with depression or anxiety in primary care

Lancet

Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis

journal of Hepatology

B-cell characteristics define HCV reinfection outcome

Gastroenterology

Gut Microbiota-Derived Butyrate Induces Epigenetic and Metabolic Reprogramming in Myeloid-Derived Suppressor Cells to Alleviate Primary Biliary Cholangitis

Clinical Gastroenterology

Efficacy and Safety of Vedolizumab and Tumor Necrosis Factor Inhibitors in the Treatment of Steroid-refractory Microscopic Colitis: A Systematic Review and Meta-analysis

Clinical Infectious Diseases

Drivers of Geographic Patterns in Outpatient Antibiotic Prescribing in the United States

Nosocomial Infections in Adults Receiving Extracorporeal Membrane Oxygenation: A Review for Infectious Diseases Clinicians

sparent reporting of practices at individual facilities in future clinical trials.

Arthritis and Rheumatology

Prevalence and Risk of Immunostimulatory Herbal Supplement Treatment Among Autoimmune Dermatology Patients

Cardiology

Mineralocorticoid Receptor Antagonism Prevents Aortic Plaque Progression and Reduces Left Ventricular Mass and Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease: The MAGMA Trial

Journals of the American College of Cardiology

Antithrombotic Strategies in Atrial Fibrillation After ACS and/or PCI: A 4-Way Comparison From AUGUSTUS

JAMA Cardiology

Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension

Journal of Clinical Endocrinology & Metabolism

The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study

] Diabetes care

Effectiveness of Multilevel and Multidomain Interventions to Improve Glycemic Control in U.S. Racial and Ethnic Minority Populations: A Systematic Review and Meta-analysis

Neurology

Graded Multidimensional Clinical and Radiologic Variation in Patients With Alzheimer Disease and Posterior Cortical Atrophy

Chest

Changes in Spirometry Interpretative Strategies

The American Journal of Respiratory and Critical Care Medicine

Physiologic Effects of Extracorporeal Membrane Oxygenation in Patients with Severe Acute Respiratory Distress Syndrome

Clinical Journal of American Society of Nephrology

A Six-Year Follow-Up of Bloodstream Infections in Hemodialysis Facilities in the United States, National Healthcare Safety Network, 2020

Kidney International reports

Global aHUS Registry Analysis of Patients Switching to Ravulizumab From Eculizumab

9 23 2024

Mon, 23 Sep 2024 09:35:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia

Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths

Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease

Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia

Journal of American Medical Association

Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging

Malaria Rapid Tests, Febrile Illness Management, and Child Mortality Across Sub-Saharan African Countries

Annals of Internal Medicine

Factors Associated With Recurrent Pediatric Firearm Injury: A 10-Year Retrospective Cohort Analysis

Class I Recalls of Cardiovascular Devices Between 2013 and 2022: A Cross-Sectional Analysis

British Medical Journal

Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis

Lancet

Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Gastroenterology

Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in

Clinical Gastroenterology

Symptom Outcomes of Celiac Disease in Those on a Gluten-free Diet

Clinical Infectious Diseases

Changes in the Appropriateness of US Outpatient Antibiotic Prescribing After the COVID-19 Outbreak

The Value of Outpatient Parenteral Antimicrobial Therapy: Better Care in 27 Minutes

Arthritis and Rheumatology

Returning Incidental Research Findings from FDG PET/CT to Participants

Circulation

Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy

Journals of the American College of Cardiology

Triglyceride Levels, Alirocumab Treatment, and Cardiovascular Outcomes After an Acute Coronary Syndrome

JAMA Cardiology

Postpartum Ambulatory Blood Pressure Patterns Following New-Onset Hypertensive Disorders of Pregnancy

Journal of Clinical Endocrinology & Metabolism

An Open-label Phase 2 Study of Eneboparatide, a Novel PTH Receptor 1 Agonist, in Hypoparathyroidism

Diabetes care

Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank

Neurology

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Chest

Effect of Corticosteroids on Long-Term Humoral and Memory T-Cell Responses in Follow-Up Visit of Hospitalized Patients With COVID-19

The American Journal of Respiratory and Critical Care Medicine

Potential Diaphragm Muscle Weakness-related Dyspnea Persists 2 Years after COVID-19 and Could Be Improved by Inspiratory Muscle Training: Results of an Observational and an Interventional Clinical Trial

Clinical Journal of American Society of Nephrology

Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury: A Randomized Controlled Trial

Kidney International reports

Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti-Phospholipase A2 Receptor Autoantibody–Positive Primary Membranous Nephropathy

9 16 2024

Mon, 16 Sep 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Asciminib in Newly Diagnosed Chronic Myeloid Leukemia

Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia

Zodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia

Journal of American Medical Association

Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer: A Multisite Randomized Clinical Trial

Tenecteplase vs Alteplase for Patients With Acute Ischemic Stroke

Annals of Internal Medicine

Hospital Type and Resilience During COVID-19 Surges

British Medical Journal

Randomised controlled trials on radiation dose fractionation in breast cancer

Lancet

De-escalation to ticagrelor monotherapy versus 12 months of dual antiplatelet therapy in patients with and without acute coronary syndromes

Cancer Journal for Clinicians

Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019

Next we will be discussing articles In the field of Gastroenterology

Here are the articles from Clinical Gastroenterology

Endoscopic Glue Injection Versus Endoscopic Human Thrombin Injection for Bleeding Gastric

Clinical Infectious Diseases

Association Between Social Vulnerability and Streptococcus pneumoniae Antimicrobial Resistance in US Adults

Quantifying the Time to Administer Outpatient Parenteral Antimicrobial Therapy

Next we will be discussing articles In the field of Rheumatology

Here are the articles from Arthritis and Rheumatology

Diversity and epitope spreading of anti-RNA polymerase III antibodies in systemic sclerosis

Journal of Clinical Rheumatology

Contemporary Patterns of Financial Toxicity Among Patients With Rheumatologic Disease in the United States

Next we will be discussing articles In the field of Cardiology

Here are the articles from Circulation

Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)

Journals of the American College of Cardiology

Serial Shock Severity Assessment Within 72 Hours After Diagnosis: A Cardiogenic Shock Working Group Report

JAMA Cardiology

Neighborhood Social Vulnerability and Premature Cardiovascular Disease in Haiti

Journal of Clinical Endocrinology & Metabolism

Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes

Diabetes care

Circulating Metabolite Biomarkers of Glycemic Control in Youth-Onset Type 2 Diabetes

Neurology

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients With ICH and Mechanical Heart Valves

Pulmonary and Critical care

Here are the articles from Chest

Nationwide Increasing Incidence of Nontuberculous Mycobacterial Diseases Among Adults in Denmark

The American Journal of Respiratory and Critical Care Medicine

Susceptible Young Adults and Development of Chronic Obstructive Pulmonary Disease Later in Life

Clinical Journal of American Society of Nephrology

Sodium Bicarbonate Treatment and Clinical Outcomes in Chronic Kidney Disease with Metabolic Acidosis: A Meta-Analysis

Kidney International reports

A Randomized Controlled Trial Comparing Automated Peritoneal Dialysis and Hemodialysis for Urgent-Start Dialysis in ESRD

9 9 2009

Mon, 09 Sep 2024 11:00:00 +0000

New England Journal of Medicine

Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

A Monoclonal Antibody to PACAP for Migraine Prevention

Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke

A New Orthonairovirus Associated with Human Febrile Illness

Journal of American Medical Association

Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial

Annals of Internal Medicine

Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort

British Medical Journal

Risk of dementia after initiation of sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in adults aged 40-69 years with type 2 diabetes

Lancet

General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants

Cancer Journal for Clinicians

Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019

journal of Hepatology

Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort

Gastroenterology

Association of GLP-1 Receptor Agonists and Hepatocellular Carcinoma Incidence and Hepatic Decompensation in Patients With Type 2 Diabetes

Clinical Gastroenterology

Inpatient Outcomes of Gastric Antral Vascular Ectasia in Those With Aortic Stenosis: A Retrospective Study of 85,000 Hospitalizations

Clinical Infectious Diseases

Development of Predictive Models to Inform a Novel Risk Categorization Framework for Antibiotic Resistance in Escherichia coli–Caused Uncomplicated Urinary Tract Infection

The Ethical Obligation to Treat Infectious Patients: A Systematic Review of Reasons

Arthritis and Rheumatology

Do Existing MRI Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow-Up?

=Journal of Clinical Rheumatology

Acute Kidney Injury in Systemic Sclerosis Beyond Scleroderma Renal Crisis: A Case-Control Study

Circulation

Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease

Journals of the American College of Cardiology

Prediction of Cumulative Exposure to Atherogenic Lipids During Early Adulthood

JAMA Cardiology

Emergency Medical Service Agency Practices and Cardiac Arrest Survival

Journal of Clinical Endocrinology & Metabolism

Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study

Diabetes care

Age of Diabetes Diagnosis and Lifetime Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Chest

Effect of Azithromycin on Asthma Remission in Adults With Persistent Uncontrolled Asthma

The American Journal of Respiratory and Critical Care Medicine

Human Neutrophils Couple Nitric Oxide Production and Extracellular Trap Formation in Allergic Asthma

Clinical Journal of American Society of Nephrology

Validation of Noninvasive Detection of Hyperkalemia by Artificial Intelligence–Enhanced Electrocardiography in High Acuity Settings

Kidney International reports

Virtual Nephron: Evaluation of a Novel Virtual Reality Educational Tool

9 2 2023

Mon, 02 Sep 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury

Journal of American Medical Association

Greenhouse Gas Emissions and Costs of Inhaler Devices in the US

Long-Term Prognosis of Patients With Myocarditis Attributed to COVID-19 mRNA Vaccination, SARS-CoV-2 Infection, or Conventional Etiologies

Annals of Internal Medicine

Sodium–Glucose Cotransporter-2 Inhibitors, Dulaglutide, and Risk for Dementia: A Population-Based Cohort Study

Efficacy of a Therapeutic Pelvic Yoga Program Versus a Physical Conditioning Program on Urinary Incontinence in Women: A Randomized Trial

British Medical Journal

Risk of dementia after initiation of sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in adults aged 40-69 years with type 2 diabetes: population based cohort study

Lancet

Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials

Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis

journal of Hepatology

One-year transplant-free survival following hospital discharge after ICU admission for ACLF in the Netherlands

Gastroenterology

Relative Efficacies of Interventions to Improve the Quality of Screening-Related Colonoscopy: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Clinical Gastroenterology

Machine Learning Predicts Patients With New-onset Diabetes at Risk of Pancreatic Cancer

Journals of the American College of Cardiology

Clinical and Analytical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay

JAMA Cardiology

Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension

Journal of Clinical Endocrinology & Metabolism

Testosterone Treatment, Weight Loss, and Health-related Quality of Life and Psychosocial Function in Men: A 2-year Randomized Controlled Trial

Neurology

Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis

Chest

Is using automatic mechanical ventilation (MV) feasible and comparable to the manual ventilation method during CPR?

Clinical Journal of American Society of Nephrology

A Six-Year Follow-Up of Bloodstream Infections in Hemodialysis Facilities in the United States, National Healthcare Safety Network, 2020

Mechanisms of Antihypertensive Effect of Chlorthalidone in Advanced Chronic Kidney Disease: A Causal Mediation Analysis

Kidney International reports

Pregnancy Among Women Receiving Chronic Dialysis in France (2006–2020)

8 26 2024

Mon, 26 Aug 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

A Randomized Trial of Intravenous Amino Acids for Kidney Protection

Azithromycin to Reduce Mortality — An Adaptive Cluster-Randomized Trial

Journal of American Medical Association

Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause

OASIS 1 and 2 Randomized Clinical Trials

Characterizing Long COVID in Children and Adolescents

NAnnals of Internal Medicine

Effect of Starting Dialysis Versus Continuing Medical Management on Survival and Home Time in Older Adults With Kidney Failure: A Target Trial Emulation Study

British Medical Journal

Suicide rates among physicians compared with the general population in studies from 20 countries: gender stratified systematic review and meta-analysis

Lancet

Activity limitations, use of assistive devices, and mortality and clinical events in 25 high-income, middle-income, and low-income countries: an analysis of the PURE study

journal of Hepatology

Treatment response and clinical event-free survival in autoimmune hepatitis: A Canadian multicentre cohort study

Evaluation of a delayed liver transplantation strategy for patients with HCC receiving bridging therapy: the DELTA-HCC study

Gastroenterology

Thoracoabdominal Wall Motion–Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial

Clinical Gastroenterology

An Accurate and Automated Method for Adenoma Detection Rate and Report Card Generation Utilizing Common Electronic Health Records

Journals of the American College of Cardiology

Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR:

JAMA Cardiology

Postpartum Ambulatory Blood Pressure Patterns Following New-Onset Hypertensive Disorders of Pregnancy

Journal of Clinical Endocrinology & Metabolism

Differential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics

Neurology

Prediction of Future Parkinson Disease Using Plasma Proteins Combined With Clinical-Demographic Measures

Chest

Changes in Spirometry Interpretative Strategies

The American Journal of Respiratory and Critical Care Medicine

Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension

Clinical Journal of American Society of Nephrology

Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury: A Randomized Controlled Trial

C3 Glomerulopathy Recurs Early after Kidney Transplantation in Serial Biopsies Performed within the First 2 Years after Transplantation

Here are the articles from Kidney International reports

Dialysis Outcomes Across Countries and Regions: A Global Perspective From the International Society of Nephrology Global Kidney Health Atlas Study

8 19 2024

Mon, 19 Aug 2024 09:40:00 +0000

New England Journal of Medicine

Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC

Cognitive Motor Dissociation in Disorders of Consciousness

An Accurate and Rapidly Calibrating Speech Neuroprosthesis

Journal of American Medical Association

Uterus Transplant in Women With Absolute Uterine-Factor Infertility

Annals of Internal Medicine

Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort

British Medical Journal

Decompression alone or with fusion for degenerative lumbar spondylolisthesis

Lancet

Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease

Journal of Clinical Oncology

Phase II Efficacy and Safety of 80 mg Osimertinib in Patients With Leptomeningeal Metastases Associated With Epidermal Growth Factor Receptor Mutation–Positive Non–Small Cell Lung Cancer (BLOSSOM)

journal of Hepatology

ALT to qHBsAg ratio predicts long-term HBsAg seroclearance after entecavir cessation in Chinese patients with chronic hepatitis B

FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma

Gastroenterology

Biopsy Proteome Scoring to Determine Mucosal Remodeling in Celiac Disease

Clinical Gastroenterology

Efficacy of Antiobesity Medications in Patients With Celiac Disease on a Gluten-free Diet: A Retrospective Matched Cohort Study

Journal of Clinical Rheumatology

Treatment Patterns for End-Stage Kidney Failure in Patients With Systemic Lupus Erythematous

Journals of the American College of Cardiology

Kidney and Cardiovascular Effectiveness of SGLT2 Inhibitors vs GLP-1 Receptor Agonists in Type 2 Diabetes

JAMA Cardiology

Neighborhood Social Vulnerability and Premature Cardiovascular Disease in Haiti

Journal of Clinical Endocrinology & Metabolism

Nonoperative, Active Surveillance of Larger Malignant and Suspicious Thyroid Nodules

Diabetes care

Determinants of Diabetes Awareness Among Hispanic/Latino Adults in the U.S., 2005–2018

Neurology

Associations of Cerebral Blood Flow Patterns With Gray and White Matter Structure in Patients With Temporal Lobe Epilepsy

Chest

Effect of Corticosteroids on Long-Term Humoral and Memory T-Cell Responses in Follow-Up Visit of Hospitalized Patients With COVID-19

The American Journal of Respiratory and Critical Care Medicine

Shift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults

Clinical Journal of American Society of Nephrology

Sodium Bicarbonate Treatment and Clinical Outcomes in Chronic Kidney Disease with Metabolic Acidosis: A Meta-Analysis

A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome

Kidney International reports

Patiromer to Reduce Albuminuria Through Increased Renin Angiotensin Aldosterone System Inhibition in Patients With CKD-A Feasibility Trial

8 12 2024

Wed, 14 Aug 2024 20:28:50 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

Post Acute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras

Journal of American Medical Association

A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users

A Randomized Clinical Trial

The Annual Cost of Cancer Screening in the United States

British Medical Journal

Intake of sugar sweetened beverages among children and adolescents in 185 countries between 1990 and 2018: population based study

Lancet

Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study

Hemato Oncology.

Cancer Journal for Clinicians

Cancer diagnosis and treatment in working-age adults: Implications for employment, health insurance coverage, and financial hardship in the United States

Journal of Clinical Oncology

LACC Trial: Final Analysis on Overall Survival Comparing Open Versus Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer

journal of Hepatology

Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes

EFIB and FNI in patients with type 2 diabetes and MASLD.

Multicentre phase II trial of cabozantinib in patients with hepatocellular carcinoma after immune checkpoint inhibitor treatment

Gastroenterology

Risk of Esophageal Adenocarcinoma After Helicobacter pylori Eradication Treatment in a Population-Based Multinational Cohort Study

Clinical Infectious Diseases

Low-Risk Staphylococcus aureus Bacteremia Patients Do Not Require Routine Diagnostic Imaging: A Multicenter, Retrospective, Cohort Study

Arthritis and Rheumatology

Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain

Journal of Clinical Rheumatology

Rheumatoid Arthritis–Related Lung Disease and Its Association With Mortality

Circulation

Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study

Journals of the American College of Cardiology

Prescription Patterns for Sodium-Glucose Cotransporter 2 Inhibitors in U.S. Health Systems

JAMA Cardiology

Emergency Medical Service Agency Practices and Cardiac Arrest Survival

Journal of Clinical Endocrinology & Metabolism

Treatment Satisfaction With Omnipod DASH in Adults With Type 1 Diabetes: A Nonblinded 1:1 Randomized Controlled Trial

EMBARK: A Randomized, Controlled Trial Comparing Three Approaches to Reducing Diabetes Distress and Improving HbA1c in Adults With Type 1 Diabetes

Neurology

MRI-Derived Modeling of Disease Progression Patterns in Patients With Temporal Lobe Epilepsy

Chest

Effect of Azithromycin on Asthma Remission in Adults With Persistent Uncontrolled Asthma

The American Journal of Respiratory and Critical Care Medicine

Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease

Clinical Journal of American Society of Nephrology

Validation of Noninvasive Detection of Hyperkalemia by Artificial Intelligence–Enhanced Electrocardiography in High Acuity Settings

A National Survey of Pregnancy and Parenthood among Nephrology Trainees: A Focus on Nephrology Fellowship

Kidney International reports

Obinutuzumab as Initial or Second-Line Therapy in Patients With Primary Membranous Nephropathy

8 5 2024

Mon, 05 Aug 2024 12:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma

Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Multiple Myeloma

Autoantibodies Targeting Nephrin in Podocytopathies

Journal of American Medical Association

Projected Changes in Statin and Antihypertensive Therapy Eligibility With the AHA PREVENT Cardiovascular Risk Equations

Addiction Consultation Services for Opioid Use Disorder Treatment Initiation and EngagementA Randomized Clinical Trial

Annals of Internal Medicine

Fatal and Nonfatal Firearm Injury Rates by Race and Ethnicity in the United States, 2019 to 2020

British Medical Journal

Intraosseous versus intravenous vascular access in upper extremity among adults with out-of-hospital cardiac arrest: cluster randomised clinical trial (VICTOR trial)

Lancet

Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study

Hepatology

Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

Clinical Gastroenterology

Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV

Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn’s Disease (EXPLORER)

Clinical Infectious Diseases

Community-Acquired Staphylococcus aureus Bacteremia Among People Who Inject Drugs: A National Cohort Study in England, 2017–2020

A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response

Arthritis and Rheumatology

Intra-Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study

Journals of the American College of Cardiology

Apixaban vs Aspirin According to CHA2DS2-VASc Score in Subclinical Atrial Fibrillation: Insights From ARTESiA

Semaglutide and NYHA Functional Class in Obesity-Related Heart Failure With Preserved Ejection Fraction: The STEP-HFpEF Program

Journal of Clinical Endocrinology & Metabolism

Comparison of the Efficacy of Ezetimibe Combination Therapy and High-Intensity Statin Monotherapy in Type 2 Diabetes

Neurology

Mechanisms of Hypercoagulability Driving Stroke Risk in Obesity: A Mendelian Randomization Study

Chest

The Efficacy and Safety of Inhaled Antibiotics for the Treatment of Bronchiectasis in Adults

Early Deep Sedation Practices Worsened During the Pandemic Among Adult Patients Without COVID-19

The American Journal of Respiratory and Critical Care Medicine

High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients

Clinical Journal of American Society of Nephrology

Genomic Testing in Patients with Kidney Failure of an Unknown Cause: A National Australian Study

Kidney International reports

Randomized Controlled Trial of Intradialytic Cognitive and Physical Training to Enhance Functional Capacity

Outcomes of Early Versus Delayed Anemia Treatment in Nondialysis-Dependent CKD

]

P2Y12 Inhibitors Refill Gap Predicts Death in Medicare Beneficiaries on Chronic Dialysis

Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use

7 29 2024

Mon, 29 Jul 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults

Journal of American Medical Association

Association Between Cost Sharing and Naloxone Prescription Dispensing

Next we will be discussing articles from Annals of Internal Medicine

Effect of Acupuncture for Methadone Reduction: A Randomized Clinical Trial

Next we will be discussing articles from British Medical Journal

Effectiveness of behavioural interventions with motivational interviewing on physical activity outcomes

Next we will be discussing articles from Lancet

Effectiveness and cost-effectiveness of an individualised, progressive walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack): a randomised controlled trial

Next we will be discussing articles In the field of Hemato Oncology.

Here are the articles from Journal of Clinical Oncology

CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non–Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy

Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma

Here are the articles from journal of Hepatology

Sex and ethnic disparities in hepatitis B evaluation and treatment across the world

Next we will be discussing articles In the field of Gastroenterology

Here are the articles from Clinical Gastroenterology

Association Between Celiac Disease and Irritable Bowel Syndrome: A Nationwide Cohort Study

Long-Term Effectiveness and Durability of COVID-19 Vaccination Among Patients With Inflammatory Bowel Disease

Low Colorectal Cancer Risk After Resection of High-Risk Pedunculated Polyps

Next we will be discussing articles In the field of Infectious Diseases

Here are the articles from Clinical Infectious Diseases

Excellence in Antibiotic Stewardship: A Mixed-Methods Study Comparing High-, Medium-, and Low-Performing Hospitals

Next we will be discussing articles In the field of Rheumatology

Here are the articles from Journal of Clinical Rheumatology

Causality Assessment Between Idiopathic Inflammatory Myopathies and Lung Cancer: A Bidirectional 2-Sample Mendelian Randomization

Here are the articles from Arthritis and Rheumatology

Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing

Next we will be discussing articles In the field of Cardiology

Here are the articles from Journals of the American College of Cardiology

Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy

Racial Differences in Diabetic Cardiomyopathy: The ARISE-HF Trial

Next we will be discussing articles In the field of Endocrinology

Here are the articles from Journal of Clinical Endocrinology & Metabolism

Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy

Next we will be discussing articles In the field of Neurology

Here are the articles from Neurology

Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core

Next we will be discussing articles In the field of Pulmonary and Critical care

Here are the articles from Chest

Anaerobic Antibiotic Coverage in Aspiration Pneumonia and the Associated Benefits and Harms

A RETROSPECTIVE COHORT STUDY

Achieving Goals of Care Decisions in Chronic Critical Illness

A MULTI-INSTITUTIONAL QUALITATIVE STUDY

Here are the articles from The American Journal of Respiratory and Critical Care Medicine

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Kinetics of β-2-Microglobulin with Hemodiafiltration and High-Flux Hemodialysis

Kidney International reports

Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort

Global Validation of a Model to Predict Reduced Estimated GFR in People With Type 2 Diabetes Without Diagnosis of CKD

Prognostication After Dialysis Withdrawal

The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy

7 22 24

Mon, 22 Jul 2024 19:18:25 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy

Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn’s Disease

Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19

Journal of American Medical Association

Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac SurgeryThe ENGAGES-Canada Randomized Clinical Trial

Annals of Internal Medicine

Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients With Cirrhosis and Atrial Fibrillation: A Nationwide Cohort Study

British Medical Journal

Lee Silverman voice treatment versus NHS speech and language therapy versus control for dysarthria in people with Parkinson’s disease (PD COMM): pragmatic, UK based, multicentre, three arm, parallel group, unblinded, randomised controlled trial

Lancet

Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomised controlled trial

Post-trial monitoring of a randomised controlled trial of intensive glycaemic control in type 2 diabetes extended from 10 years to 24 years (UKPDS 91)

Hemato Oncology.

Journal of Clinical Oncology

Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial

Phase Ib Study of Unesbulin (PTC596) Plus Dacarbazine for the Treatment of Locally Recurrent, Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma

journal of Hepatology

Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease

Gastroenterology

Clinical Gastroenterology

Validation of the Laryngeal Cognitive-Affective Tool

Outcomes of High-Grade Immune Checkpoint Inhibitor Hepatitis in Hospitalized and Nonhospitalized Patients

Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions

Infectious Diseases

Clinical Infectious Diseases

Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections

Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis

Rheumatology

Journal of Clinical Rheumatology

Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis

Arthritis and Rheumatology

Using Two Predictive Models to Capture Two Types of Poor Outcomes in Knee Arthroplasty: A Multisite Longitudinal Cohort Study

Cardiology

Journals of the American College of Cardiology

Effects of Rapid Uptitration of Neurohormonal Blockade on Effective,

OCT-Guided vs Angiography-Guided Coronary Stent Implantation in Complex Lesions: An ILUMIEN IV Substudy

Endocrinology

Here are the articles from Journal of Clinical Endocrinology & Metabolism

Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes

Neurology

Here are the articles from Neurology

Prevalence of Suicidality in Adolescents With Newly Diagnosed Focal Epilepsy at Diagnosis and Over the Following 36 Months

Next we will be discussing articles In the field of Pulmonary and Critical care

Chest

International Variation in Severe Exacerbation Rates in Patients With Severe Asthma

Clinician- and Patient-Identified Solutions to Reduce the Fragmentation of Post-ICU Care in Australia

The American Journal of Respiratory and Critical Care Medicine

The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use

Predicting Obstructive Sleep Apnea Based on Computed Tomography Scans Using Deep Learning Models

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function: ASSESS-AKI

Kidney International reports

Effects of Once-Weekly Semaglutide on Kidney Disease Outcomes by KDIGO Risk Category in the SUSTAIN 6 Trial

Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Results from a Phase III Clinical Trial

Prospective Study of Change in Skin Autofluorescence Over Time and Mortality in People Receiving Hemodialysis

Etelcalcetide use During Maintenance Hemodialysis and Incidence of Parathyroidectomy After Kidney Transplantation

6 24 2024

Mon, 24 Jun 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma

APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

Noninvasive Ventilation for Preoxygenation during Emergency Intubation

A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia

Journal of American Medical Association

Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis

A Randomized Clinical Trial

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction

The DEFENDER Randomized Clinical Trial

Annals of Internal Medicine

Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease

British Medical Journal

Lateral episiotomy or no episiotomy in vacuum assisted delivery in nulliparous women (EVA): multicentre, open label, randomised controlled trial

Journal of Clinical Oncology

Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022

Clinical Gastroenterology

Glucagon-like Peptide-1 Receptor Agonist Use in Patients With Liver Cirrhosis and Type 2 Diabetes

Coconut Water Induces Clinical Remission in Mild to Moderate Ulcerative Colitis: Double-blind Placebo-controlled Trial

Journal of Clinical Rheumatology

Factors Associated With Distress Related to Perceived Dignity in Patients With Rheumatic Diseases

Arthritis and Rheumatology

Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study

Circulation

Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial

American College of Cardiology

TAVR or SAVR for Failed Bioprosthetic Aortic Valves

Journal of Clinical Endocrinology & Metabolism

Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia

Neurology:

Cardiopulmonary Coupling Spectrogram as an Ambulatory Method for Assessing Sleep Disorders in Patients With Autoimmune Encephalitis

Chest

Effect of Atypical Sleep EEG Patterns on Weaning From Prolonged Mechanical Ventilation

Clinical Journal of American Society of Nephrology

Evaluation and Measurement Properties of a Patient-Reported Experience Measure for Home Dialysis

Kidney International reports

Lithium-Associated Kidney Failure: Predictors and Outcomes

6 17 2024

Mon, 17 Jun 2024 10:15:00 +0000

Hi, This Week in Medicine, we will be discussing

Hemato Oncology.

New England Journal of Medicine

Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

Journal of Clinical Oncology

Updated Analysis of Comparative Toxicity of Proton and Photon Radiation for Prostate Cancer

Gastroenterology

Clinical Gastroenterology

Association Between Vonoprazan and the Risk of Gastric Cancer After Helicobacter pylori Eradication

Impact of Treatment Response on Risk of Serious Infections in Patients With Crohn’s Disease: Secondary Analysis of the PYRAMID Registry

Infectious Diseases:

From Journal of American Medical Association

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

Clinical Infectious Diseases

Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections

Rheumatology

Journal of Clinical Rheumatology

Comparative Effectiveness of Tofacitinib and Adalimumab in Axial Spondyloarthritis: A Real-World Clinical Context Multicenter Study

Arthritis and Rheumatology

Hydroxychloroquine in Lupus Pregnancy and Risk of Preeclampsia

Cardiology

Annals of Internal Medicine

The Effect of Heat Exposure on Myocardial Blood Flow and Cardiovascular Function

British Medical Journal

Antiplatelet therapy after coronary artery bypass surgery: five year follow-up of randomised DACAB trial

Circulation

Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial

American College of Cardiology

Evaluate Renal Function With Semaglutide Once Weekly

Endocrinology

Journal of Clinical Endocrinology & Metabolism

Cushing Syndrome Is Associated With Gut Microbial Dysbiosis and Cortisol-Degrading Bacteria

Neurology

Lancet

Neurology:

Herpes Simplex Virus Encephalitis in Patients With Autoimmune Conditions or Exposure to Immunomodulatory Medications

Pulmonary and Critical care

New England Journal of Medicine

Early Diagnosis and Treatment of COPD and Asthma — A Randomized, Controlled Trial

American Medical Association

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial

Chest

National and Local Direct Medical Cost Burden of COPD in the United States From 2016 to 2019 and Projections Through 2029

Clinical Journal of American Society of Nephrology

Protected Time for Program Administration among Nephrology Program Leadership in the United States

Kidney International reports

Aversion to a High Salt Taste is Disturbed in Patients With CKD

6 10 2024

Mon, 10 Jun 2024 08:40:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon Cancer

Self-Expanding or Balloon-Expandable TAVR in Patients with a Small Aortic Annulus

Journal of American Medical Association

Home Blood Pressure Telemonitoring and Nurse Case Management in Black and Hispanic Patients With Stroke

Mortality and Morbidity in Adults With Rheumatic Heart Disease

Annals of Internal Medicine

Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer: A

British Medical Journal

Mailed feedback to primary care physicians on antibiotic prescribing for patients aged 65 years and older: pragmatic, factorial randomised controlled trial

Lancet

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Journal of Clinical Oncology

Doxorubicin Exposure and Breast Cancer Risk in Survivors of Adolescent and Adult Hodgkin Lymphoma

Clinical Gastroenterology

Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study

Chronic Viral Hepatitis B and C Outweigh MASLD in the Associated Risk of Cirrhosis and HCC

Journal of Clinical Rheumatology

Axial Spondyloarthritis: Does Magnetic Resonance Imaging Classification Improve Report Interpretation

Arthritis and Rheumatology

Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus

Circulation

Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial

American College of Cardiology

Degenerative MR Due to Flail Leaflet According to Sex

Journal of Clinical Endocrinology & Metabolism

Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus

Neurology:

Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes: A Secondary Analysis of the ESCAPE Trial

Chest

Safety and Efficacy of Clofazimine as an Alternative for Rifampicin in Mycobacterium avium Complex Pulmonary Disease Treatment

Comparison of Pirfenidone and Nintedanib

Clinical Journal of American Society of Nephrology

Preventive Pharmacological Therapy and Risk of Recurrent Urinary Stone Disease

Kidney International reports

Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in CKD Patients With COVID-19

6 3 2024

Mon, 03 Jun 2024 20:03:19 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy

Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke

Journal of American Medical Association

Aspirin vs Placebo as Adjuvant Therapy for Breast CancerThe Alliance A011502 Randomized Trial

Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine ReplacementA Randomized Clinical Trial

Annals of Internal Medicine

Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men

Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults

British Medical Journal

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma

Epidural analgesia during labour and severe maternal morbidity

Journal of Clinical Oncology

Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort

journal of Hepatology

Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population

Clinical Gastroenterology

Validated Clinical Score to Predict Gastroesophageal Reflux in Patients With Chronic Laryngeal Symptoms: COuGH RefluX

Hypercholesterolemia Is Associated With Dysregulation of Lipid Metabolism and Poor Prognosis in Primary Biliary Cholangitis

Journal of Clinical Rheumatology

Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis

Arthritis and Rheumatology

Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis–Associated Lymphoproliferative Disorders

Circulation

Comparison of Incidence and Prognostic Impact of Ischemic, Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry

American College of Cardiology

Coronary Atherosclerotic Plaque Activity and Risk of MI

Journal of Clinical Endocrinology & Metabolism

Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study

Neurology:

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease

Chest

Tolerability Outcomes of American Thoracic Society/Infectious Diseases Society of America Guideline-Recommended Multidrug Antibiotic Treatment for Mycobacterium avium Complex Pulmonary Disease in US Medicare Beneficiaries With Bronchiectasis

Prophylactic Minocycline for Delirium in Critically Ill Patients

Clinical Journal of American Society of Nephrology

Sotagliflozin and Kidney Outcomes, Kidney Function, and Albuminuria in Type 2 Diabetes and CKD: A Secondary Analysis of the SCORED Trial

Kidney International reports

Pregnancy and Family Planning in Women With Kidney Disease

5 27 2024

Mon, 27 May 2024 09:30:00 +0000

Hi, This Week in Medicine, we will be discussing

Journal of American Medical Association

Hypertension and Kidney Function After Living Kidney Donation

Annals of Internal Medicine

Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance

Artificial Intelligence for Real-Time Prediction of the Histology of Colorectal Polyps by General Endoscopists

British Medical Journal

Epidural analgesia during labour and severe maternal morbidity

Clinical Gastroenterology

Older Patients With Acute on Chronic Liver Failure Have a Higher Waitlist Mortality, but Acceptable Post Liver Transplantation Survival When Compared to Younger Patients

Prolonged Gastrointestinal Manifestations After Recovery From COVID-19

Clinical Infectious Diseases

External Validation of the 2023 Duke–International Society for Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis

Journal of Clinical Rheumatology

Rheumatology High Blood Pressure Protocol Reduces Disparities, But Delays Remain for External Primary Care

Journals of the American College of Cardiology

Mandibular Advancement vs CPAP for Blood Pressure Reduction in Patients With Obstructive Sleep Apnea

Journal of Clinical Endocrinology & Metabolism

Erythrocytosis Is Rare With Exogenous Testosterone in Gender-Affirming Hormone Therapy

Chest

Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support

The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19

Clinical Journal of American Society of Nephrology

Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy: A Randomized Controlled Trial

Evaluating ApoL1 Genetic Testing Policy Options for Transplant Centers: A Delphi Consensus Panel Project with Stakeholders

Kidney International reports

Pregnancy and Family Planning in Women With Kidney Disease

Lithium-Associated Kidney Failure: Predictors and Outcomes

5 20 2024

Mon, 20 May 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Andexanet for Factor Xa Inhibitor–Associated Acute Intracerebral Hemorrhage

Perioperative Nivolumab in Resectable Lung Cancer

Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk

Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome

Journal of American Medical Association

Text Messages With Financial Incentives for Men With Obesity

A Randomized Clinical Trial

An Adaptive Behavioral Intervention for Weight Loss Management

A Randomized Clinical Trial

Nature Medicine

Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure

Lancet

Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial

Journal of Clinical Oncology

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women

journal of Hepatology

Optimal hepatitis C treatment adherence patterns and sustained virologic response among people who inject drugs: The HERO study

Background & Aims

Clinical Gastroenterology

Prospective Comparison of Attenuation Imaging and Controlled Attenuation Parameter for Liver Steatosis Diagnosis in Patients With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Misclassified Alcohol-related Liver Disease is Common in Presumed Metabolic Dysfunction-associated Steatotic Liver Disease and Highly Increases Risk for Future Cirrhosis

Burden of Crohn’s Disease in the United States Medicaid Population, 2010–2019

Clinical Infectious Diseases

The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence

Outcomes of SARS-CoV-2 Omicron Variant Infections Compared With Seasonal Influenza and Respiratory Syncytial Virus Infections in Adults Attending the Emergency Department: A Multicenter Cohort Study

Evaluation of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Criteria in a Multicenter Cohort of Patients With Suspected Infective Endocarditis

Journal of Clinical Rheumatology

The Relationship Between Anti–SSA-52 and Interstitial Lung Disease

Risk Factors for Pneumocystis jirovecii Pneumonia in Children With Systemic Lupus Erythematosus Exposed to Prolonged High-Dose Glucocorticoids

Arthritis and Rheumatology

Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register

Circulation

Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells

American College of Cardiology

Cardiomyopathies in Children and Adolescents

Journals of the American College of Cardiology

Association of Lipoprotein(a) Levels With Myocardial Infarction in Patients With Low-Attenuation Plaque

Journal of Clinical Endocrinology & Metabolism

Characterizing Genetic Alterations Related to Radioiodine Avidity in Metastatic Thyroid Cancer

Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus

Next we will be discussing articles from Neurology:

Covert Cerebrovascular Changes in People With Heart Disease: A Systematic Review and Meta-Analysis

Chest

Longitudinal Effects of Elexacaftor/Tezacaftor/Ivacaftor

Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest

The American Journal of Respiratory and Critical Care Medicine

Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease

Alveolar Hemorrhage in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results of an International Randomized Controlled Trial (PEXIVAS)

Clinical Journal of American Society of Nephrology

Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis

Associations of Changes in Bone Turnover Markers with Change in Bone Mineral Density in Kidney Transplant Patients

Kidney International reports

Associations Between Prematurity, Birthweight, and Adolescence Blood Pressure in a Nationwide Cohort

A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population

5 13 2-24

Mon, 13 May 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

Journal of American Medical Association

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores With Patient Outcomes

Annals of Internal Medicine

The Safety of Outpatient Health Care: Review of Electronic Health Records

Diagnostic Strategy Using Color Doppler Ultrasound of Temporal Arteries in Patients With High Clinical Suspicion of Giant Cell Arteritis: A Prospective Cohort Study

Nature Medicine

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis

Lancet

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial

Journal of Clinical Oncology

Phase II Trial of nab-Sirolimus in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT): Long-Term Efficacy and Safety Update

journal of Hepatology

Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease

Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration

Clinical Gastroenterology

Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Screening for Fibrosis Promotes Lifestyle Changes: A Prospective Cohort Study in 4796 Individuals

ENTERPRET: A Randomized Controlled Trial of Vedolizumab Dose Optimization in Patients With Ulcerative Colitis Who Have Early Nonresponse

Clinical Infectious Diseases

Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection

A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of COVID-19 Prognostic Scores

Compared Performance of the 2023 Duke–International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort

Journal of Clinical Rheumatology

Measurement of Neutrophil Extracellular Traps as a Biomarker for the Differential Diagnosis Between Antineutrophil Cytoplasmic Antibody–Positive Individuals With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Nonautoimmune Diseases

Prediction of Treatment Effect of SLE-ITP Patients Based on Cost-Sensitive Neural Network and Variational Autoencoder

Arthritis and Rheumatology

Anti-Inflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

American College of Cardiology

LGE CMR and Sudden Death in Hypertrophic Cardiomyopathy

Journals of the American College of Cardiology

Sacubitril/Valsartan-Related Hypotension in Patients With Heart Failure and Preserved or Mildly Reduced Ejection Fraction

Journal of Clinical Endocrinology & Metabolism

Association Between a History of Breast Cancer and Decreased Thyroid Cancer-specific Mortality

Neurology:

Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort

Chest

Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals

The American Journal of Respiratory and Critical Care Medicine

Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial

Clinical Journal of American Society of Nephrology

Associations of Angiopoietin 2 and Vascular Endothelial Growth Factor-A Concentrations with Clinical End Points

The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications

Kidney International reports

Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome

Aversion to a High Salt Taste is Disturbed in Patients With CKD

5 6 2024

Mon, 06 May 2024 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria

Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction

Transcatheter or Surgical Treatment of Aortic-Valve Stenosis

Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura

Journal of American Medical Association

Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth

Youth Experiencing Parental Death Due to Drug Poisoning and Firearm Violence in the US, 1999-2020

Annals of Internal Medicine

Deep Learning to Estimate Cardiovascular Risk From Chest Radiographs: A Risk Prediction Study

Nature Medicine

Equitable implementation of a precision digital health program for glucose management in individuals with newly diagnosed type 1 diabetes

British Medical Journal

Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

Lancet

Diagnosis of common health conditions among autistic adults in the UK: evidence from a matched cohort study

Journal of Clinical Oncology

Improved Disease-Free Survival With Adjuvant Chemotherapy After Nephroureterectomy for Upper Tract Urothelial Cancer: Final Results of the POUT Trial

journal of Hepatology

Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis

Clinical Gastroenterology

Reduction of Upper Gastrointestinal Bleeding Risk With Proton Pump Inhibitor Therapy in Asian Patients With Atrial Fibrillation Receiving Direct Oral Anticoagulant: A Nationwide Population-based Cohort Study

Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD

Cardiovascular Safety of Ozanimod in Patients With Ulcerative Colitis: True North and Open-Label Extension Analyses

Clinical Infectious Diseases

Can Chatbot Artificial Intelligence Replace Infectious Diseases Physicians in the Management of Bloodstream Infections? A Prospective Cohort Study

PROCESS Trial: Effect of Duloxetine Premedication for Postherpetic Neuralgia Within 72 Hours of Herpes Zoster Reactivation—A Randomized Controlled Trial

Evaluation of the Specificity of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Classification for Infective Endocarditis

Journal of Clinical Rheumatology

Chronic Nonbacterial Osteomyelitis Associated With Familial Mediterranean Fever in Children

Comparative Levels of Urinary Biomarkers of Renal Injury and Inflammation Among Patients Arthritis and Rheumatology

A Mobile Health Application Integrated in the Electronic Health Record for Rheumatoid Arthritis Patient–Reported Outcomes: A Controlled Interrupted Time-Series Analysis of Impact on Visit Efficiency

Circulation

Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

American College of Cardiology

Catheter Ablation as First-Line Therapy in Persistent AF

Journals of the American College of Cardiology

Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality

Journal of Clinical Endocrinology & Metabolism

Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment in Children With Growth Hormone Deficiency

Stratification of Atherosclerosis based on Plasma Metabolic States

Neurology:

Neurodevelopmental and Functional Outcomes Following In Utero Exposure to Antiseizure Medication: A Systematic Review

Chest

Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders

Individual Risk Factors of PM2.5 Associated With Wintertime Mortality in Urban Patients With COPD

The American Journal of Respiratory and Critical Care Medicine

Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease

Deep Learning Classification of Usual Interstitial Pneumonia Predicts Outcomes

Clinical Journal of American Society of Nephrology

Vaccine Effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 in CKD

Trust, Multidimensional Health Literacy, and Medication Adherence among Patients Undergoing Long-Term Hemodialysis

Kidney International reports

Aortic Dilatation in Children and Young People With ADPKD

Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in CKD Patients With COVID-19

4 29 2024

Mon, 29 Apr 2024 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Empagliflozin after Acute Myocardial Infarction

Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis

FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction

Nutritional Support for Moderate-to-Late–Preterm Infants — A Randomized Trial

Journal of American Medical Association

Neurodevelopmental Outcomes After Late Preterm Antenatal Corticosteroids

The ALPS Follow-Up Study

Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments

Annals of Internal Medicine

Disparities in Tuberculosis Incidence by Race and Ethnicity Among the U.S.-Born Population in the United States, 2011 to 2021: An Analysis of National Disease Registry Data

Nature Medicine

Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses

British Medical Journal

Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study

Lancet

Optimised prevention of postnatal HIV transmission in Zambia and Burkina Faso (PROMISE-EPI): a phase 3, open-label, randomised controlled trial

Journal of Clinical Oncology

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Final Results of CheckMate 722

journal of Hepatology

An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis

A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma

Clinical Gastroenterology

Financial Burden of Hepatocellular Carcinoma Screening in Patients With Cirrhosis

Chronic Liver Disease and Cirrhosis Mortality Rates Are Disproportionately Increasing in Younger Women in the United States Between 2000-2020

Real-World Surgical and Endoscopic Recurrence Based on Risk Profiles and Prophylaxis Utilization in Postoperative Crohn’s Disease

Clinical Infectious Diseases

Brain Abscess Caused by Oral Cavity Bacteria: A Nationwide, Population-based Cohort Study

Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C): A Stepped Wedge Cluster Randomized Trial

Early Mortality After the First Dose of COVID-19 Vaccination: A Target Trial Emulation

Journal of infectious Diseases

Early Initiation of Antiretroviral Therapy Preserves the Metabolic Function of CD4+ T Cells in Subtype C Human Immunodeficiency Virus 1 Infection

Arthritis and Rheumatology

Weight Loss Induced by Antiobesity Medications and All-Cause Mortality Among Patients With Knee or Hip Osteoarthritis

American College of Cardiology

Comparison of IVUS-Guided vs. Angiography-Guided Angioplasty for the Outcomes of Drug-Coated Balloon in the Treatment of Femoropopliteal Artery Disease

Journals of the American College of Cardiology

Effect of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Congenital Heart Disease

Journal of Clinical Endocrinology & Metabolism

Modification Effects of Albuminuria on the Association Between Kidney Function and Development of Anemia in Diabetes

Association of Urine Albumin to Creatinine Ratio With Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus

Neurology:

Association of Time to Thrombolysis With Early Reperfusion After Alteplase and Tenecteplase in Patients With Large Vessel Occlusion

Identification of Distinct Brain MRI Phenotypes and Their Association With Long-Term Dementia Risk in Community-Dwelling Older Adults

Chest

Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support

The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19

Impact of Left Heart Disease Risk Factors on Outcomes in Pulmonary Arterial Hypertension Therapy

The American Journal of Respiratory and Critical Care Medicine

Oxygen-Saturation Targets and Cognitive and Functional Outcomes in Mechanically Ventilated Adults

Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome

Clinical Journal of American Society of Nephrology

Time-Varying Determinants of Graft Failure in Pediatric Kidney Transplantation in Europe

Trends and Specific Causes of Cardiovascular Mortality after Kidney Transplantation in Finland

Kidney International reports

A Randomized Controlled Study of Efficacy and Safety of Accelerated Versus Standard Hepatitis B Vaccination in Patients With Advanced CKD

Exploring Preconceptions as Barriers to Peritoneal Dialysis Eligibility: A Global Scenario-Based Survey of Kidney Care Physicians

4 22 2024

Mon, 22 Apr 2024 09:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction

Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock

Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes

Journal of American Medical Association

Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban

Non–High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events

Annals of Internal Medicine

Deep Learning to Estimate Cardiovascular Risk From Chest Radiographs: A Risk Prediction Study

Nature Medicine

Development and validation of a new algorithm for improved cardiovascular risk prediction

British Medical Journal

Temporal trends in lifetime risks of atrial fibrillation and its complications between 2000 and 2022: Danish, nationwide, population based cohort study

Lancet

Patient, family caregiver, and economic outcomes of an integrated screening and novel stepped collaborative care intervention in the oncology setting in the USA (CARES): a randomised, parallel, phase 3 trial

Journal of Clinical Oncology

Phase III, Randomized Study of Atezolizumab Plus Bevacizumab and Chemotherapy in Patients With EGFR- or ALK-Mutated Non–Small-Cell Lung Cancer (ATTLAS, KCSG-LU19-04)

journal of Hepatology

Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

A new clinical and prognostic characterization of the patterns of decompensation of cirrhosis

Clinical Gastroenterology

Statins Are Associated With a Decreased Risk of Severe Liver Disease in Individuals With Noncirrhotic Chronic Liver Disease

Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

Histologic Activity in Inflammatory Bowel Disease and Risk of Serious Infections: A Nationwide Study

The Diagnostic Performance of Fecal Immunochemical Tests for Detecting Advanced Neoplasia at Surveillance Colonoscopy

Clinical Infectious Diseases

Clinical Outcomes of Patients With Nontyphoidal SalmonellaInfections by Isolate Resistance—Foodborne Diseases Active Surveillance Network, 10 US Sites, 2004–2018

Clinical Impact of Multiplex Molecular Diagnostic Testing in Children With Acute Gastroenteritis Presenting to an Emergency Department: A Multicenter Prospective Study

Timing and Predictors of Loss of Infectivity Among Healthcare Workers With Mild Primary and Recurrent COVID-19: A Prospective Observational Cohort Study

Journal of infectious Diseases

The Effects of Human Immunodeficiency Virus Type 1 (HIV-1) Antigen-Expanded Specific T-Cell Therapy and Vorinostat on Persistent HIV-1 Infection in People With HIV on Antiretroviral Therapy

Arthritis and Rheumatology

Towards the Lowest Efficacious Dose: Results From a Multicenter Noninferiority Randomized Open-Label Controlled Trial Assessing Tocilizumab or Abatacept Injection Spacing in Rheumatoid Arthritis in Remission

American College of Cardiology

Preventive Coronary Intervention on Stenosis With Functionally Insignificant Vulnerable Plaque

Journals of the American College of Cardiology

Water Conservation Overrides Osmotic Diuresis During SGLT2 Inhibition in Patients With Heart Failure

Journal of Clinical Endocrinology & Metabolism

Discontinuation of Drug Treatment in Cushing's Disease Not Cured by Pituitary Surgery

Dasiglucagon for the Treatment of Congenital Hyperinsulinism: A Randomized Phase 3 Trial in Infants and Children

Neurology:

Trends in Cognitive Function Before and After Diabetes Onset: The China Health and Retirement Longitudinal Study

Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds

Chest

Longitudinal Effects of Elexacaftor/Tezacaftor/Ivacaftor

Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest

Hospital Policy Variation in Addressing Decisions to Withhold and Withdraw Life-Sustaining Treatment

The American Journal of Respiratory and Critical Care Medicine

Heterogeneity of Benefit from Earlier Time-to-Antibiotics for Sepsis

Clinical Journal of American Society of Nephrology

Association of Bioimpedance Parameters with Increases in Blood Pressure during Hemodialysis

Drug-Coated Balloon Angioplasty for Dysfunctional Arteriovenous Hemodialysis Fistulae: A Randomized Controlled Trial

Kidney International reports

Patient Perspectives of Center-Specific Reporting in Kidney Failure Care: An Australian Qualitative Study

Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition

4 15 2024

Mon, 15 Apr 2024 09:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer

Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage

Journal of American Medical Association

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a)

Nature Medicine

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

British Medical Journal

Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study

Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Lancet

Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial

Journal of Clinical Oncology

Genomic Classification and Individualized Prognosis in Multiple Myeloma

journal of Hepatology

Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B

Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis

Clinical Gastroenterology

Significance of Crypt Atypia in Barrett’s Esophagus: A Clinical, Molecular, and Outcome Study

Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis

Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis

Benefits of Prokinetics, Gastroparesis Diet, or Neuromodulators Alone or in Combination for Symptoms of Gastroparesis

Clinical Infectious Diseases

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir

SARS-CoV-2 Infection and Postacute Risk of Non–Coronavirus Disease 2019 Infectious Disease Hospitalizations: A Nationwide Cohort Study of Danish Adults Aged ≥50 Years

Journal of infectious Diseases

Journal of Clinical Rheumatology

Chronic Nonbacterial Osteomyelitis Associated With Familial Mediterranean Fever in Children

Arthritis and Rheumatology

Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive–Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study

Circulation

mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis

American College of Cardiology

One-Month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes

Journals of the American College of Cardiology

Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score

Journal of Clinical Endocrinology & Metabolism

Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention

Lifestyle Intervention With Smartphone App and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial

Neurology:

Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study

Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults

Chest

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals

The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology

The American Journal of Respiratory and Critical Care Medicine

SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset

Clinical Journal of American Society of Nephrology

Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria

Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD

Kidney International reports

Implications of Implementing the 2021 CKD-EPI Equation Without Race on Managing Patients With Kidney Disease in British Columbia, Canada

Pregnancies in Women With Kidney Failure on Home Dialysis in the United States

4 8 2024

Tue, 09 Apr 2024 00:44:01 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Omitting Axillary Dissection in Breast Cancer with Sentinel-Node Metastases

Trial of Lixisenatide in Early Parkinson’s Disease

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Pragmatic Trial of Hospitalization Rate in Chronic Kidney Disease

Journal of American Medical Association

Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial

Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a)

Annals of Internal Medicine

Association of Low Glomerular Filtration Rate With Adverse Outcomes at Older Age in a Large Population With Routinely Measured Cystatin C

Nature Medicine

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

British Medical Journal

Use of progestogens and the risk of intracranial meningioma: national case-control study

Lancet

Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial

Journal of Clinical Oncology

Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study

journal of Hepatology

Preventing liver disease with policy measures to tackle alcohol consumption and obesity: The HEPAHEALTH II study

Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease

Clinical Gastroenterology

The Index of Severity for Eosinophilic Esophagitis (I-SEE) Reflects Longitudinal Clinicopathologic Changes in Children

Alcoholic Foamy Degeneration, an Entity Resembling Alcohol-Associated Hepatitis: Diagnosis, Prognosis, and Molecular Profiling

Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials

Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome From Adolescence to Adulthood

Clinical liver disease

Acceptability of hepatitis C screening and treatment during pregnancy in pregnant women in Egypt, Pakistan, and Ukraine: A cross-sectional survey

Clinical Infectious Diseases

Is Short-Course Antibiotic Therapy Suitable for Pseudomonas aeruginosa Bloodstream Infections in Onco-hematology Patients With Febrile Neutropenia? Results of a Multi-institutional Analysis

Bartonella quintana Endocarditis: A Systematic Review of Individual Cases

Socioeconomic and Demographic Risk Factors for SARS-CoV-2 Seropositivity Among Healthcare Workers in a UK Hospital: A Prospective Cohort Study

Journal of infectious Diseases

Effectiveness of BNT162b2 BA.4/5 Bivalent mRNA Vaccine Against Symptomatic COVID-19 Among Immunocompetent Individuals Testing at a Large US Retail Pharmacy

Journal of Clinical Rheumatology

Transition From Pediatric to Adult Rheumatology Care: An Exploratory Study From Latin America

Arthritis and Rheumatology

Poly-Refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease With Distinct Inflammatory and Noninflammatory Phenotypes

Circulation

Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy

American College of Cardiology

Journals of the American College of Cardiology

Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease

Journal of Clinical Endocrinology & Metabolism

Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditi

Metabolic Profiles of Type 2 Diabetes and Their Association With Renal Complications

Next we will be discussing articles from Neurology:

Remote Ischemic Conditioning With Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults

Chest

Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders

Individual Risk Factors of PM2.5 Associated With Wintertime Mortality in Urban Patients With COPD

High-Resolution CT Scan Fibrotic Patterns in Stage IV Pulmonary Sarcoidosis

The American Journal of Respiratory and Critical Care Medicine

Antimicrobial Drug Penetration Is Enhanced by Lung Tissue Inflammation and Injury

Clinical Journal of American Society of Nephrology

Strategies to Guide Preemptive Waitlisting and Equity in Waittime Accrual by Race/Ethnicity

Association of eGFR and Albuminuria with Venous Thromboembolism

Kidney International reports

Acute Kidney Injury Duration and 20-Year Risks of CKD and Cardiovascular Disease

Systematic Review of Women Leading and Participating in Nephrology Randomized Clinical Trials

4 1 2024

Mon, 01 Apr 2024 10:05:00 +0000

Hi, This Week in Medicine, we will start with the article from Journal of American Medical Association

Health Equity Adjustment and Hospital Performance in the Medicare Value-Based Purchasing Program

British Medical Journal

Use of progestogens and the risk of intracranial meningioma: national case-control study

Journal of Clinical Oncology

International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

journal of Hepatology

Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours

Clinical Gastroenterology

Endoscopic Removal of Premalignant Lesions Reduces Long-Term Colorectal Cancer Risk: Results From the Japan Polyp Study

Nutritional Assessment in Patients after Gastric Electrical Stimulation (GES)

Journal of infectious Diseases

Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes

Arthritis and Rheumatology

Risk of Hypertensive Disorders and Preterm Birth in Pregnant Women With Systemic Vasculitides: A Nationwide Population-Based Cohort Study

Circulation

Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs

American College of Cardiology

Revealing Mechanisms and Investigating Efficacy of Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis - REMOVE

Journals of the American College of Cardiology

Intraoperative Anemia Mediates Sex Disparity in Operative Mortality After Coronary Artery Bypass Grafting

Journal of Clinical Endocrinology & Metabolism

Structural and Functional Brain Changes After Glucocorticoid Therapy in Thyroid-Associated Ophthalmopathy

Neurology:

Sex Differences in the Role of Multimorbidity on Poststroke Disability: The Taiwan Stroke Registry

Chest

Do-Not-Resuscitate Orders by COVID-19 Status Throughout the First Year of the COVID-19 Pandemic

Exploring the Association of Male Sex With Adverse Outcomes in Severe Bronchopulmonary Dysplasia

The American Journal of Respiratory and Critical Care Medicine

Lung Injury Prediction Model in Bone Marrow Transplantation: A Multicenter Cohort Study

Clinical Journal of American Society of Nephrology

Time-Varying Determinants of Graft Failure in Pediatric Kidney Transplantation in Europe

Trends and Specific Causes of Cardiovascular Mortality after Kidney Transplantation in Finland

Kidney International reports

Familial Variability of Disease Severity in Adult Patients With ADPKD

3 25 2024

Mon, 25 Mar 2024 09:15:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure

Ribociclib plus Endocrine Therapy in Early Breast Cancer

Intrathecal Gene Therapy for Giant Axonal Neuropathy

Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency

Journal of American Medical Association

Vibration-Controlled Transient Elastography Scores to Predict Liver-Related Events in Steatotic Liver Disease

Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies

Annals of Internal Medicine

Association of Low Glomerular Filtration Rate With Adverse Outcomes at Older Age in a Large Population With Routinely Measured Cystatin C

Surgery, Needle Fasciotomy, or Collagenase Injection for Dupuytren Contracture: A Randomized Controlled Trial

British Medical Journal

Current safeguards, risk mitigation, and transparency measures of large language models against the generation of health disinformation: repeated cross sectional analysis

Lancet

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Journal of Clinical Oncology

Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG)

journal of Hepatology

Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease

Clinical Gastroenterology

Buprenorphine Versus Diclofenac for Pain Relief in Acute Pancreatitis: A Double-Blinded Randomized Controlled Trial

Sex Differences in Treatment Response to Nucleos(t)ide Therapy in Chronic Hepatitis B: A Multicenter Longitudinal Study

Clinical Infectious Diseases

Emulating a Target Trial of Shorter Compared to Longer Course of Antibiotic Therapy for Gram-Negative Bacteremia

Journal of Clinical Rheumatology

Persistent Risk of Developing Autoimmune Diseases Associated With COVID-19: An Observational Study Using an Electronic Medical Record Database in Japan

Arthritis and Rheumatology

Three-Dimensional Chromosomal Landscape Revealing miR-146a Dysfunctional Enhancer in Lupus and Establishing a CRISPR-Mediated Approach to Inhibit the Interferon Pathway

Circulation

Arterial Thromboembolism in Patients With Atrial Fibrillation and CHA2DS2-VASc Score 1: A Nationwide Study

American College of Cardiology

TAVR or SAVR in Severe Aortic Stenosis and Small Aortic Annulus

Journals of the American College of Cardiology

Angiotensin Receptor-Neprilysin Inhibition in Patients With STEMI vs NSTEMI

Journal of Clinical Endocrinology & Metabolism

High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study

Neurology:

Effect of Evobrutinib on Slowly Expanding Lesion Volume in Relapsing Multiple Sclerosis: A Post Hoc Analysis of a Phase 2 Trial

Chest

Preserved Ratio Impaired Spirometry and COPD Accelerate Frailty Progression

Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity

Prospective Evaluation of Venous Excess Ultrasound for Estimation of Venous Congestion

The American Journal of Respiratory and Critical Care Medicine

Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial – A Randomized Clinical Trial

Clinical Journal of American Society of Nephrology

Association of Bioimpedance Parameters with Increases in Blood Pressure during Hemodialysis

Drug-Coated Balloon Angioplasty for Dysfunctional Arteriovenous Hemodialysis Fistulae: A Randomized Controlled Trial

Kidney International reports

Ecological Momentary Assessment to Explore Fatigue, Mood, and Physical Activity Levels in People Receiving Peritoneal Dialysis

3 18 2024

Mon, 18 Mar 2024 09:40:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening

Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening

Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria

RSV Prefusion F Protein–Based Maternal Vaccine — Preterm Birth and Journal of American Medical Association

To estimate the self-reported prevalence of and sociodemographic and policy factors associated with Δ8-THC and marijuana use among US adolescents in the past 12 months.

Annals of Internal Medicine

Health Care Contact Days Among Older Adults in Traditional Medicare: A Cross-Sectional Study

Trends in Discharge Rates for Acute Pulmonary Embolism in U.S. Emergency Departments

Nature Medicine

Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial

British Medical Journal

25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis

Cervical pessary versus vaginal progesterone in women with a singleton pregnancy, a short cervix, and no history of spontaneous preterm birth at less than 34 weeks’ gestation: open label, multicentre, randomised, controlled trial

Lancet

Intracytoplasmic sperm injection versus conventional in-vitro fertilisation for couples with infertility with non-severe male factor: a multicentre, open-label, randomised controlled trial

Journal of Clinical Oncology

HLA Haplotypes and Relapse After Hematopoietic Cell Transplantation

journal of Hepatology

Association between public health policies on alcohol and worldwide cancer, liver disease and cardiovascular disease outcomes

Clinical Gastroenterology

Prevalence and Predictors of Barrett’s Esophagus After Negative Initial Endoscopy: Analysis From Two National Databases

Incidence of Etiology-specific Hepatocellular Carcinoma: Diverging Trends and Significant Heterogeneity by Race and Ethnicity

Clinical Infectious Diseases

An Open-Label, Randomized Trial Comparing Fidaxomicin With Oral Vancomycin for the Treatment of Clostridioides difficile Infection in Hospitalized Patients Receiving Concomitant Antibiotics for Concurrent Infections

Journal of Clinical Rheumatology

Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort

Arthritis and Rheumatology

Strength Training Is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Circulation

Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program

American College of Cardiology

Prospective ARNI versus ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After MI

Journals of the American College of Cardiology

Surveillance Stress Testing After Percutaneous Intervention for Patients With Multivessel or Left Main Coronary Disease

Journal of Clinical Endocrinology & Metabolism

Trends and Components of Thyroid Status Evaluation in Commercially Insured Adults in the United States, 2006-2020

Neurology:

Prognostic Role of Ventricular Size and Its Dynamics in Patients With Leptomeningeal Metastasis From Solid Tumors

Chest

Using Trajectories of Bedside Vital Signs to Identify COVID-19 Subphenotypes

Prevalence, Risk Factors, Clinical Features, and Outcome of Influenza-Associated Pulmonary Aspergillosis in Critically Ill Patients

The American Journal of Respiratory and Critical Care Medicine

Geo-economic Influence on the Effect of Fluid Volume for Sepsis Resuscitation: A Meta-Analysis

Clinical and Translational Gastroenterology

Higher and Sustained Cell-Mediated Immune Responses after Three Doses of mRNA COVID-19 Vaccine In Patients with Inflammatory Bowel Disease on Anti-TNF Therapy

Clinical Journal of American Society of Nephrology

Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria

Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD

Kidney International reports

Novel Colorimetric and Light Scatter Methods to Identify and Manage Peritoneal Dialysis-Associated Peritonitis at the Point-of-Care

3 11 2024

Mon, 11 Mar 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer

Omalizumab for the Treatment of Multiple Food Allergies

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis

Journal of American Medical Association

Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis

Annals of Internal Medicine

Health Care Contact Days Among Older Adults in Traditional Medicare

Nature Medicine

Sex-specific genetic architecture of blood pressure

British Medical Journal

Comparison of prior authorization across insurers: cross sectional evidence from Medicare Advantage

Lancet

The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment

Journal of Clinical Oncology

Long-Term Results of the Dasatinib-Blinatumomab Protocol for Adult Philadelphia-Positive ALL

journal of Hepatology

Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH

Clinical Gastroenterology

The Severity of Reduced Esophageal Distensibility Parallels Eosinophilic Esophagitis Disease Duration

Snare Tip Soft Coagulation vs Argon Plasma Coagulation vs No Margin Treatment After Large Nonpedunculated Colorectal Polyp Resection: a Randomized Trial

Clinical liver disease

Screening for hepatitis C as part of an opioid stewardship quality improvement initiative: Identifying infected patients and analyzing linkage to care

Clinical Infectious Diseases

Persistence of Detectable Pathogens by Culture-Independent Systems (T2 Magnetic Resonance) in Patients With Bloodstream Infection: Prognostic Role and Possible Clinical Implications

Journal of Clinical Rheumatology

Interleukin 6 Levels and Disease Activity in Takayasu Arteritis: A Systematic Review With Meta-analysis

Arthritis and Rheumatology

Methotrexate Safety and Efficacy in Combination Therapies in Patients With Early Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial

Circulation

Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients With Atrial Fibrillation

American College of Cardiology

Arm and Ankle BP Indices, PAD, and Mortality

Journals of the American College of Cardiology

Lipoprotein(a) and Major Adverse Cardiovascular Events in Patients With or Without Baseline Atherosclerotic Cardiovascular Disease

Journal of Clinical Endocrinology & Metabolism

Predictive Risk Score for Postparathyroidectomy Hungry Bone Syndrome in Patients With Secondary Hyperparathyroidism

Neurology:

Cinpanemab in Early Parkinson Disease: Evaluation of Biomarker Results From the Phase 2 SPARK Clinical Trial

Chest

Legionnaires Disease in Solid Organ Transplant Recipients

Background

External Validation of the BACES Score in Canadian Patients With Nontuberculous Mycobacterial Pulmonary Disease

The American Journal of Respiratory and Critical Care Medicine

Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988–2019

Clinical and Translational Gastroenterology

Genetic Factors Associated with Adverse Pregnancy Outcomes in Chronic Pancreatitis

Clinical Journal of American Society of Nephrology

Strategies to Guide Preemptive Waitlisting and Equity in Waittime Accrual by Race/Ethnicity

Association of eGFR and Albuminuria with Venous Thromboembolism

Kidney International reports

Providing Hemodialysis in Unstable Areas: An Assessment and Framework for Effective Care

3 5 2024

Mon, 04 Mar 2024 09:30:00 +0000

New England Journal of Medicine

A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis

Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis

Cognition and Memory after Covid-19 in a Large Community Sample

Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer

Journal of American Medical Association

Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes

Annals of Internal Medicine

A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2

Nature Medicine

Impact of extreme weather events on healthcare utilization and mortality in the United States

British Medical Journal

Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses

Added benefit and revenues of oncology drugs approved by the European Medicines Agency between 1995 and 2020: retrospective cohort study

Lancet

Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELE

Background

Journal of Clinical Oncology

Clinical Validation of Human Papilloma Virus Circulating Tumor DNA for Early Detection of Residual Disease After Chemoradiation in Cervical Cancer

Clinical Gastroenterology

Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis

Antimullerian Hormone, a Marker of Ovarian Reserve, Is Protective Against Presence and Severity of NASH in Premenopausal Women

Clinical Infectious Diseases

Moving Beyond Mortality: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

Journal of Clinical Rheumatology

Evaluating Provider Perceptions of Telehealth Utility in Outpatient Rheumatology Telehealth Encounters

Arthritis and Rheumatology

Kidney Outcomes and Preservation of Kidney Function With Obinutuzumab in Patients With Lupus Nephritis: A Post Hoc Analysis of the NOBILITY Trial

Circulation

Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease

American College of Cardiology

Plasma Ferritin Levels and Incident HF in Older Adults

American College of Cardiology

Clinical Presentation, Classification, and Outcomes of Cardiogenic Shock in Children

Journal of Clinical Endocrinology & Metabolism

At any Level of Adiposity, Relatively Elevated Leptin Concentrations Are Associated With Decreased Insulin Sensitivity

Sex Hormones, the Stool Microbiome, and Subclinical Atherosclerosis in Women With and Without HIV

Neurology:

Association Between β-Amyloid Accumulation and Incident Dementia in Individuals 80 Years or Older Without Dementia

MRI vs CT for Baseline Imaging Evaluation in Acute Large Artery Ischemic Stroke: A Subanalysis of the SWIFT-DIRECT Trial

The American Journal of Respiratory and Critical Care Medicine

Elexacaftor/Tezacaftor/Ivacaftor Treatment and Depression-related Events

Clinical Gastroenterology AND Hepatology

Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ)

Hepatocellular Carcinoma Diagnosis and Management in 2021: A National Veterans Affairs Quality Improvement Project

Clinical and Translational Gastroenterology

Differences in mucosal permeability among patients with ulcerative colitis classified based on the colonic location and disease activity

Clinical Journal of American Society of Nephrology

Effect of Intensive Blood Pressure Control on Kidney Outcomes: Long-Term Electronic Health Record–Based Post-Trial Follow-Up of SPRINT

Effects of Steady Glucose Concentration Peritoneal Dialysis on Ultrafiltration Volume and Sodium Removal: A Pilot Crossover Trial

Pulmonary Rehabilitation Is Associated With Decreased Exacerbation and Mortality in Patients With COPD

Kidney International reports

Trajectory of GFR Decline and Fluctuation in Albuminuria Leading to End-Stage Kidney Disease in Patients With Biopsy-Confirmed Diabetic Kidney Disease

Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment in CKD

2 26 2024

Mon, 26 Feb 2024 10:50:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Biomarker Changes during 20 Years Preceding Alzheimer’s Disease

Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera

Journal of American Medical Association

Examining Excess Mortality Associated With the COVID-19 Pandemic for Renters Threatened With Eviction

Annals of Internal Medicine

Autoimmune Disorders Associated With Surgical Remission of Cushing’s Disease

A Cohort Study

Nature Medicine

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

British Medical Journal

Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study

Short term exposure to low level ambient fine particulate matter and natural cause, cardiovascular, and respiratory morbidity

Lancet

Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial

Journal of Clinical Oncology

Costs of Cancer Prevention: Physical and Psychosocial Sequelae of Risk-Reducing Total Gastrectomy

Clinical Gastroenterology

An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan

Hepatocellular Carcinoma Diagnosis and Management in 2021: A National Veterans Affairs Quality Improvement Project

Clinical liver disease

Screening for hepatitis C as part of an opioid stewardship quality improvement initiative: Identifying infected patients and analyzing linkage to care

Clinical Infectious Diseases

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions

Journal of Clinical Rheumatology

Unveiling the Link Between Antiphospholipid Antibodies and Cognitive Dysfunction in the Almenara Lupus Cohort

Arthritis and Rheumatology

Derivation and Internal Validation of a Disease-Specific Cardiovascular Risk Prediction Model for Patients With Psoriatic Arthritis and Psoriasis

Circulation

Arrhythmic Risk in Biventricular Pacing Compared With Left Bundle Branch Area Pacing: Results From the I-CLAS Study

American College of Cardiology

Validation of a Protein Risk Score for Mortality in HF

American College of Cardiology

Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis

Journal of Clinical Endocrinology & Metabolism

Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity

Neurology:

Geographic Disparities in Access to Neurologists and Multiple Sclerosis Care in the United States

Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration

Chest

Outcomes of Intermittent Multidrug IV Therapy for Refractory Mycobacterium abscessus Pulmonary Disease

Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records

The American Journal of Respiratory and Critical Care Medicine

Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis

Clinical Gastroenterology AND Hepatology

An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan

Association of Renin-Angiotensin System Inhibition With Liver-Related Events and Mortality in Compensated Cirrhosis

Clinical and Translational Gastroenterology

Clinical outcomes before and after prucalopride treatment: an observational study in patients with chronic idiopathic constipation in the USA

Clinical Journal of American Society of Nephrology

Comparative Safety of Antidepressants in Adults with CKD

Evaluation of Opening Offers Early for Deceased Donor Kidneys at Risk of Nonutilization

Kidney International reports

Influenza Vaccine Administration and Effectiveness Among Children and Adults With Glomerular Disease

Impact of Remote Monitoring on Standardized Outcomes in Nephrology-Peritoneal Dialysis

2 19 2024

Mon, 19 Feb 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Inhibition of CD40L with Frexalimab in Multiple Sclerosis

Electronic Nicotine-Delivery Systems for Smoking Cessation

Cefepime–Taniborbactam in Complicated Urinary Tract Infection

Journal of American Medical Association

Mass Azithromycin Distribution to Prevent Child Mortality in Burkina Faso

Annals of Internal Medicine

Surgery, Needle Fasciotomy, or Collagenase Injection for Dupuytren Contracture

A Randomized Controlled Trial

Nature Medicine

Effectiveness and safety of telehealth medication abortion in the USA

British Medical Journal

Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials

Lancet

Chemoprevention for malaria with monthly intermittent preventive treatment with dihydroartemisinin–piperaquine in pregnant women living with HIV on daily co-trimoxazole in Kenya and Malawi: a randomised, double-blind, placebo-controlled trial

Journal of Clinical Oncology

DNA Mutational Profiling in Patients With Colorectal Cancer Treated With Standard of Care Reveals Differences in Outcome and Racial Distribution of Mutations

Clinical Gastroenterology

Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing

Association of Renin-Angiotensin System Inhibition With Liver-Related Events and Mortality in Compensated Cirrhosis

Clinical liver disease

Screening for hepatitis C as part of an opioid stewardship quality improvement initiative: Identifying infected patients and analyzing linkage to care

Arthritis and Rheumatology

Genetic Influence on Osteoarthritis Versus Other Rheumatic Diseases

Circulation

Associations Between End-Tidal Carbon Dioxide During Pediatric Cardiopulmonary Resuscitation, Cardiopulmonary Resuscitation Quality, and Survival

Journals of the American College of Cardiology

Universal Risk Prediction for Individuals With and Without Atherosclerotic Cardiovascular Disease

Journal of Clinical Endocrinology & Metabolism

Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or MalignantGet a

Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort

Neurology:

Hospitalizations and Mortality From Myasthenia Gravis: Trends From 2 US National Datasets

Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis: Results From the Randomized Phase 2 Vivacity-MG Study

Chest

Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India

Peripheral Administration of Norepinephrine

A PROSPECTIVE OBSERVATIONAL STUDY

The American Journal of Respiratory and Critical Care Medicine

Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema

Clinical Gastroenterology AND Hepatology

Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing

Age-Dependent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study

Clinical Journal of American Society of Nephrology

Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial

Kidney International reports

Implementation of a 1-Day Living Kidney Donor Evaluation Program: A Qualitative Analysis of Donor Candidate and Stakeholder Perspectives

An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD

2 12 2024

Mon, 12 Feb 2024 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis

An Oral Interleukin-23–Receptor Antagonist Peptide for Plaque Psoriasis

Journal of American Medical Association

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy

The ARCADIA Randomized Clinical Trial

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke

The MARVEL Randomized Clinical Trial

Annals of Internal Medicine

Reducing Care Overuse in Older Patients Using Professional Norms and Accountability

A Cluster Randomized Controlled Trial

Trends in Psychological Distress and Outpatient Mental Health Care of Adults During the COVID-19 Era

Nature Medicine

Reductions in smoking due to ratification of the Framework Convention for Tobacco Control in 171 countries

British Medical Journal

Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study

Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial

Lancet

Cultural engagement and prevalence of pain in socially isolated older people: a longitudinal modified treatment policy approach

Journal of Clinical Oncology

Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial

journal of Hepatology

CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis

Clinical Gastroenterology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

Blood

Three-year follow-up analysis of axicabtagene ciloleucel in relapsed/refractory indolent non-Hodgkin lymphoma (ZUMA-5)

Journal of Clinical Rheumatology

Racial Disparities in Diagnosis and Treatment of Patients With Dermatomyositis of Different Skin Tones

Arthritis and Rheumatology

Anti–Citrullinated Protein Antibodies With Multiple Specificities Ameliorate Collagen Antibody–Induced Arthritis in a Time-Dependent Manner

Circulation

Long-Term Mortality in Patients With Severe Hypercholesterolemia Phenotype From a Racial and Ethnically Diverse US Cohort

Next article from

American College of Cardiology

E-Cigarettes vs. Varenicline and Nicotine Gum as Aid to Stop Smoking

Journals of the American College of Cardiology

Randomized Trial of Effect of Bariatric Surgery on Blood Pressure After 5 Years

Journal of Clinical Endocrinology & Metabolism

Prevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease

Neurology:

Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy

Chest

Clinical Response and Remission in Patients With Severe Asthma Treated With Biologic Therapies

The American Journal of Respiratory and Critical Care Medicine

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Clinical Gastroenterology AND Hepatology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

Clinical Journal of American Society of Nephrology

Regional Citrate Anticoagulation versus No Anticoagulation for CKRT in Patients with Liver Failure with Increased Bleeding Risk

Kidney International reports

Implementation of the ASCENT Trial to Improve Transplant Waitlisting Access

2 5 2024

Mon, 05 Feb 2024 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults

Skin Antisepsis before Surgical Fixation of Extremity Fractures

Trial of N-Acetyl-l-Leucine in Niemann–Pick Disease Type C

CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema

Journal of American Medical Association

Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula

Functional Outcomes After Localized Prostate Cancer Treatment

Nature Medicine

First-line sugemalimab with chemotherapy for advanced esophageal squamous cell carcinoma: a randomized phase 3 study

British Medical Journal

Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England

Lancet

Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial

Journal of Clinical Oncology

Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA

journal of Hepatology

Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories

Clinical Gastroenterology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

endent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study

Arthritis and Rheumatology

Kidney Outcomes and Preservation of Kidney Function With Obinutuzumab in Patients With Lupus Nephritis: A Post Hoc Analysis of the NOBILITY Trial

Circulation

Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial

American College of Cardiology

CRP Modifies Lp(a)-Related Risk for CHD

Journals of the American College of Cardiology

Outcomes According to Coronary Revascularization Modality in the ISCHEMIA Trial

Journal of Clinical Endocrinology & Metabolism

Prevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease

Tirzepatide Immunogenicity on Pharmacokinetics, Efficacy, and Safety: Analysis of Data From Phase 3 Studies

Neurology:

Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy

Bisphosphonates in Glucocorticoid-Treated Patients With Duchenne Muscular Dystrophy: A Systematic Review and Grading of the Evidence

Chest

Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?

The American Journal of Respiratory and Critical Care Medicine

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Clinical Gastroenterology AND Hepatology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis

Clinical and Translational Gastroenterology

Development and Validation of Serum Markers as Noninvasive Diagnostic Methods for Achalasia

Clinical Kidney Journal

Differentiating primary and secondary FSGS using non-invasive urine biomarkers

1 29 2024

Mon, 29 Jan 2024 11:30:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease

Journal of American Medical Association

Rape-Related Pregnancies in the 14 US States With Total Abortion Bans

International Consensus Criteria for Pediatric Sepsis and Septic Shock

Functional Outcomes After Localized Prostate Cancer Treatment

Cancer Diagnoses After Recent Weight Loss

Recreational and Medical Cannabis Legalization and Opioid Prescriptions and Mortality

Opioid Prescribing Patterns After Imposition of Setting-Specific Limits on Prescription Duration

Annals of Internal Medicine

Cumulative Incidence of Thiazide-Induced Hyponatremia

HIV Testing and Preexposure Prophylaxis Prescriptions Among U.S. Commercially Insured Transgender Men and Women, 2014 to 2021

Nature Medicine

British Medical Journal

Ecological study estimating melanoma overdiagnosis in the USA using the lifetime risk method

De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a systematic review and network meta-analysis

Lancet

Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial

JAMA Cardiology

Polygenic Risk in Families With Spontaneous Coronary Artery Dissection

1 22 2024

Mon, 22 Jan 2024 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Testosterone Treatment and Fractures in Men with Hypogonadism

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

Azithromycin during Routine Well-Infant Visits to Prevent Death

Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19

Journal of American Medical Association

Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss

Annals of Internal Medicine

Effectiveness of Recombinant Zoster Vaccine Against Herpes Zoster in a Real-World Setting

Nature Medicine

Health effects associated with exposure to secondhand smoke: a Burden of Proof study

Lancet

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Circulation

ChaMP-CMD: A Phenotype-Blinded, Randomized Controlled, Cross-Over Trial

American College of Cardiology

Arrhythmic Mitral Valve Prolapse in Unexplained Cardiac Arrest

Journals of the American College of Cardiology

Health Status After Transcatheter Tricuspid-Valve Repair in Patients With Severe Tricuspid Regurgitation

Journal of Clinical Endocrinology & Metabolism

Acute Statin Withdrawal Does not Interfere With the Improvements of a Session of Exercise in Postprandial Metabolism

Association Between Free Fatty Acids and Cardiometabolic Risk in Coronary Artery Disease: Results From the PROMISE Study

journal of Hepatology

Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Clinical Gastroenterology AND Hepatology

Regional Differences in Clinical Presentation and Prognosis of Patients With Post–Sustained Virologic Response Hepatocellular Carcinoma

Evolution of Symptoms After Ustekinumab Induction Therapy in Patients With Crohn’s Disease

Clinical Gastroenterology

A Delphi Method for Development of a Barrett’s Esophagus Question Prompt List as a Communication Tool for Optimal Patient-physician Communication

Journal of infectious Diseases

Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020

Chest

Epidemiology and Clinical Patterns of Lung Abscesses in ICU

A FRENCH MULTICENTER RETROSPECTIVE STUDY

The American Journal of Respiratory and Critical Care Medicine

The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation

Clinical Journal of American Society of Nephrology

Associations of Biomarkers of Tubular Injury and Inflammation with Biopsy Features in Type 1 Diabetes

Kidney International reports

CKD is the Major Cause of Death in Uddanam: A Population-Representative Study Using Smart Verbal Autopsy

Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence

Exercise-Induced Fluid Retention, Cardiac Volume Overload, and Peripheral Edema in Ultra-Distance Cyclists

Neurology:

Initiation of Antiseizure Medications by US Board-Certified Neurologists After a First Unprovoked Seizure Based on EEG Findings

Journal of Clinical Oncology

Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial

Journal of Clinical Rheumatology

Racial Disparities in Diagnosis and Treatment of Patients With Dermatomyositis of Different Skin Tones

Arthritis and Rheumatology

A Randomized Controlled Neuroimaging Trial of Cognitive Behavioral Therapy for Fibromyalgia Pain

1 15 2024

Mon, 15 Jan 2024 10:55:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

Repotrectinib in ROS1 Fusion–Positive Non–Small-Cell Lung Cancer

Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy

Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy

Journal of American Medical Association

Social Risk and Dialysis Facility Performance in the First Year of the ESRD Treatment Choices Model

Measuring Equity in Readmission as a Distinct Assessment of Hospital Performance

Importance Equity is an essential domain of health care quality. The Centers for Medicare & Medicaid Services (CMS) developed 2 Disparity Methods that together assess equity in clinical outcomes.

Annals of Internal Medicine

Real-World Effectiveness of BNT162b2 Against Infection and Severe Diseases in Children and Adolescents

Nature Medicine

Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme

British Medical Journal

Perinatal depression and risk of mortality: nationwide, register based study in Sweden

Next article from Lancet

Perinatal morbidity among women with a previous caesarean delivery (PRISMA trial): a cluster-randomised trial

Circulation

Inflammation and Cholesterol as Predictors of Cardiovascular Events Among 13 970 Contemporary High-Risk Patients With Statin Intolerance

American College of Cardiology

Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2

Treatment Effect of IV Iron in Iron-Deficient Heart Failure

Journal of Clinical Endocrinology & Metabolism

A Randomized Clinical Trial of Intravenous Methylprednisolone With 2 Protocols in Patients With Graves Orbitopathy

Metabolites as Risk Factors for Diabetic Retinopathy in Patients With Type 2 Diabetes: A 12-Year Follow-up Study

journal of Hepatology

A prospective, multicenter, three-cohort study evaluating contrast-induced acute kidney injury (CI-AKI) in patients with cirrhosis

Background & Aims

Clinical Gastroenterology AND Hepatology

Helicobacter pylori Burden in the United States According to Individual Demographics and Geography: A Nationwide Analysis of the Veterans Healthcare System

Tumor Necrosis Factor Inhibitors in Inflammatory Bowel Disease and Risk of Immune Mediated Inflammatory Diseases

Clinical Gastroenterology

A Delphi Method for Development of a Barrett’s Esophagus Question Prompt List as a Communication Tool for Optimal Patient-physician Communication

Chest

Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?

A SYSTEMATIC REVIEW AND META-ANALYSIS

The American Journal of Respiratory and Critical Care Medicine

Application of Global Lung Function Initiative Global Spirometry Reference Equations across a Large, Multicenter Pulmonary Function Lab Population

Clinical Journal of American Society of Nephrology

Performance of ChatGPT on Nephrology Test Questions

Kidney International reports

Higher Nocturnal Blood Pressure and Blunted Nocturnal Dipping Are Associated With Decreased Daytime Urinary Sodium and Potassium Excretion in Patients With CKD

Validation of a Core Patient-Reported Outcome Measure for Life Participation in Kidney Transplant Recipients: the SONG Life Participation Instrument

Postreperfusion Renal Allograft Biopsy Predicts Outcome of Single-Kidney Transplantation: A 10-Year Observational Study in China

Neurology:

Exploring Factors That Prolong the Diagnosis of Myasthenia Gravis

JAMA Neurology:

APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry

Journal of Clinical Oncology

Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial

Journal of Clinical Rheumatology

Burden of Other Musculoskeletal Disorders in Latin America and the Caribbean: Findings of Global Burden of Disease Study 2019

Arthritis and Rheumatology

Distinct Scleroderma Autoantibody Profiles Stratify Patients for Cancer Risk at Scleroderma Onset and During the Disease Course

1 8 2024

Mon, 08 Jan 2024 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Drug-Eluting Resorbable Scaffold versus Angioplasty for Infrapopliteal Artery Disease

A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy

Liquefied Petroleum Gas or Biomass Cooking and Severe Infant Pneumonia

Journal of American Medical Association

Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With ObesityThe SURMOUNT-4 Randomized Clinical Trial

Pregnancy After Breast Cancer in Young BRCA CarriersAn International Hospital-Based Cohort

Nature Medicine

A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial

British Medical Journal

Retail demand for emergency contraception in United States following New Year holiday: time series study

Lancet

Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial

Circulation

Invasive Endotyping in Patients With Angina and No Obstructive Coronary Artery Disease: A Randomized Controlled Trial

American College of Cardiology

Pivotal Investigation of Safety and Efficacy of Drug-Eluting Resorbable Scaffold Treatment-Below the Knee

Revascularization for Ischemic Ventricular Dysfunction

Journal of Clinical Endocrinology & Metabolism

Efficacy and Safety of Teprotumumab in Patients With Thyroid Eye Disease of Long Duration and Low Disease Activity

Higher Risk of Incident Hyperthyroidism in Patients With Atrial Fibrillation

journal of Hepatology

Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis

Clinical Gastroenterology AND Hepatology

Achalasia is Strongly Associated With Eosinophilic Esophagitis and Other Allergic Disorde

Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study

The American Journal of Respiratory and Critical Care Medicine

Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations

Kidney International reports

Systematic Review of Cardiovascular Benefits and Safety of Sacubitril-Valsartan in End-Stage Kidney Disease

Improved Renal Function in Initial Treatment Improves Patient Survival, Renal Outcomes, and Glucocorticoid-Related Complications in IgG4-Related Kidney Disease in Japan

Iptacopan in Idiopathic Immune Complex–Mediated Membranoproliferative Glomerulonephritis: Protocol of the APPARENT Multicenter, Randomized Phase 3 Study

Neurology:

Health and Wellness Coaching for 5-Year Projected Cardiovascular Health: A Randomized Controlled Trial

JAMA Neurology:

Atrial Fibrillation In Patients With Stroke Attributed to Large- or Small-Vessel Disease

Journal of Clinical Oncology

Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone for the Treatment of High-Risk Newly Diagnosed Multiple Myeloma

Journal of Clinical Rheumatology

Racial Disparities in Diagnosis and Treatment of Patients With Dermatomyositis of Different Skin Tones

Arthritis and Rheumatology

Safety and Efficacy of Long-Term Voclosporin Treatment for Lupus Nephritis in the Phase 3 AURORA 2 Clinical Trial

01 01 2024

Mon, 01 Jan 2024 11:00:00 +0000

Happy New year! Hope 2024 will bring peace,happiness and healing to the world.

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke

Nirsevimab for Prevention of Hospitalizations Due to RSV in Infants

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia

Journal of American Medical Association

Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition

Annals of Internal Medicine

Effect of Complementary Interventions to Redesign Care on Teamwork and Quality for Hospitalized Medical Patients

A Pragmatic Controlled Trial

Nature Medicine

The infant gut virome is associated with preschool asthma risk independently of bacteria

Lancet

Treatment of severe symptomatic aortic valve stenosis using non-invasive ultrasound therapy: a cohort study

Journal of Clinical Oncology

Health-Related Quality of Life With Nivolumab Plus Chemotherapy Versus Chemotherapy in Patients With Advanced Gastric/Gastroesophageal Junction Cancer or Esophageal Adenocarcinoma From CheckMate 649

journal of Hepatology

Familial coaggregation of MASLD with hepatocellular carcinoma and adverse liver outcomes: Nationwide multigenerational cohort study

Clinical Gastroenterology

Recent Trends in the Incidence of Gastric Cancer in the United States

Defecation Symptoms in Relation to Stool Consistency Significantly Reflect the Dyssynergic Pattern in High-resolution Anorectal Manometry in Constipated Patients

Clinical Infectious Diseases

Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial

Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis With Liver Fibrosis as Predictors of New-Onset Diabetes Mellitus in People With HIV: A Longitudinal Cohort Study

Journal of Clinical Rheumatology

Evaluation of Gastrointestinal System Complaints and Comorbidities in Pediatric Familial Mediterranean Fever Patients

Arthritis and Rheumatology

Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the SLICC Inception Cohort

Circulation

Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury

American College of Cardiology

Role of Polyunsaturated Fat in Modifying CVD Risk

Journals of the American College of Cardiology

Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis

Journal of Clinical Endocrinology & Metabolism

Association of Body Mass Index and Its Change With Incident Diabetes Mellitus

The Presence and Severity of NAFLD are Associated With Cognitive Impairment and Hippocampal Damage

Neurology:

Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA: A Pooled Analysis

Chest

Indicators of Neighborhood-Level Socioeconomic Position and Pediatric Critical Illness

The American Journal of Respiratory and Critical Care Medicine

Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial—MIST-3

Clinical Gastroenterology AND Hepatology

Epidemiology of Gastric Malignancies 2000–2018 According to Histology: A Population-Based Analysis of Incidence and Temporal Trends

Background & Aims

Clinical Journal of American Society of Nephrology

Vascular Access–Related Distal Ischemia Requiring Intervention: Frequency, Risk Factors, and Consequences

Kidney International reports

Contemporary Practice of Anemia Treatment Among Dialysis Patients in the United States

12 25 2023

Mon, 25 Dec 2023 09:55:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina

Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women

Simvastatin in Critically Ill Patients with Covid-19

Journal of American Medical Association

Association Between Daily Toothbrushing and Hospital-Acquired Pneumonia

A Systematic Review and Meta-Analysis

Annals of Internal Medicine

Inappropriate Prescribing to Older Patients by Nurse Practitioners and Primary Care Physicians

Nature Medicine

The infant gut virome is associated with preschool asthma risk independently of bacteria

Lancet

Ubrogepant for the treatment of migraine attacks during the prodrome: a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial in the USA

Journal of Clinical Oncology

Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer

journal of Hepatology

Progression of non-alcoholic fatty liver disease and long-term outcomes: A nationwide paired liver biopsy cohort study

Clinical Gastroenterology

The Overlap Subgroup of Functional Dyspepsia Exhibits More Severely Impaired Gastric and Autonomic Functions

Effect of Premedication With Pronase Before Upper Gastrointestinal Endoscopy: A Multicenter Prospective Randomized Controlled Study

Clinical Infectious Diseases

Remdesivir Reduced Mortality in Immunocompromised Patients Hospitalized for COVID-19 Across Variant Waves: Findings From Routine Clinical Practice

Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort

Journal of Clinical Rheumatology

Barriers and Solutions for Pediatric Rheumatology Referrals in a Rural Area: Physician Survey Results From Montana State

Arthritis and Rheumatology

Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study

Circulation

Dapagliflozin and Apparent Treatment-Resistant Hypertension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The DELIVER Trial

American College of Cardiology

Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity

Journals of the American College of Cardiology

Lipoprotein(a) and Risks of Peripheral Artery Disease, Abdominal Aortic Aneurysm, and Major Adverse Limb Events

Journal of Clinical Endocrinology & Metabolism

Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography

The Glucose Challenge Test in Pregnancy Identifies Future Risk of Diabetes

Neurology:

Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS

Chest

Association Between Rome Classification Among Hospitalized Patients With COPD Exacerbations and Short-Term and Intermediate-Term Outcomes

The American Journal of Respiratory and Critical Care Medicine

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial

Clinical Gastroenterology AND Hepatology

Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976–2022: A Systematic Review and Meta-analysis

Clinical Journal of American Society of Nephrology

Interstitial Eosinophilic Aggregates and Kidney Outcome in Patients with CKD

Kidney International reports

Patient Survival With Extended Home Hemodialysis Compared to In-Center Conventional Hemodialysis

12 18 2023

Mon, 18 Dec 2023 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

Recombinant or Standard-Dose Influenza Vaccine in Adults under 65 Years of Age

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma

Annals of Internal Medicine

Development and Validation of the CANHEART Population-Based Laboratory Prediction Models for Atherosclerotic Cardiovascular Disease

Nature Medicine

Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial

Lancet

Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial

Journal of Clinical Oncology

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma

journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US

Clinical Gastroenterology

Reflux Symptoms Increase Following Sleeve Gastrectomy Despite Triage of Symptomatic Patients to Roux-en-Y Gastric Bypass

Safety and Efficacy of Endoscopic Full Thickness Resection of Upper Gastrointestinal Lesions Using a Full Thickness Resection Device: A Systematic Review and Meta-analysis

Clinical Infectious Diseases

Patient Characteristics, Microbiology, and Mortality of Infective Endocarditis After Transcatheter Aortic Valve Implantation

Temporal Trends in Hepatitis C–Related Hospitalizations, United States, 2000–2019

Journal of Clinical Rheumatology

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

Arthritis and Rheumatology

A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

Circulation

Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD

American College of Cardiology

Predictors of Outcomes in Mild Pulmonary Hypertension

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

Journal of Clinical Endocrinology & Metabolism

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy

Neurology:

Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke

Chest

CT Scan Differences of Pulmonary TB According to Presence of Pleural Effusion

The American Journal of Respiratory and Critical Care Medicine

Impact of Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma on Symptoms, Quality of Life, Healthcare Use, and Work Productivity

Clinical Gastroenterology AND Hepatology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

Clinical Journal of American Society of Nephrology

Cystatin C–Based eGFR Changes during Gender-Affirming Hormone Therapy in Transgender Individuals

Kidney International reports

Sex/Gender-Based Disparities in Early Transplant Access by Attributed Cause of Kidney Disease–Evidence from a Multiregional Cohort in the Southeast United States

12 11 2023

Mon, 11 Dec 2023 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C

Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes

Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes

Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer

Journal of American Medical Association

Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial

Pregnancy After Breast Cancer in Young BRCA Carriers

Annals of Internal Medicine

Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma

Lancet

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial

Journal of Clinical Oncology

Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer

Journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

Clinical Gastroenterology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

Blood

Clinical Outcomes in Patients with High-Dose Methotrexate Toxicity Treated with Vs. without Glucarpidase

Clinical Infectious Diseases

Diagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration

Journal of Clinical Rheumatology

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

Arthritis and Rheumatology

Poly-refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease with Distinct Inflammatory and Non-inflammatory Phenotypes

Circulation

Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study

American College of Cardiology

Long-Term Safety of Inclisiran for Treatment of Hypercholesterolemia

Journals of the American College of Cardiology

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

Journal of Clinical Endocrinology & Metabolism

Effective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH

Neurology:

Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis

Chest

Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure

The American Journal of Respiratory and Critical Care Medicine

Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study

Clinical and Translational Gastroenterology

Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study

Clinical Journal of American Society of Nephrology

Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD

Kidney International reports

Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy

12 4 2023

Mon, 04 Dec 2023 11:00:00 +0000

New England Journal of Medicine

Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors

Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia

Tarlatamab for Patients with Previously Treated Small-Cell Lung Cancer

Journal of American Medical Association

Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning

Effect of Personalized Risk-Reduction Strategies on Cognition and Dementia Risk Profile Among Older Adults

The SMARRT Randomized Clinical Trial

Annals of Internal Medicine

Inappropriate Prescribing to Older Patients by Nurse Practitioners and Primary Care Physicians

Nature Medicine

Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial

British Medical Journal

Social media use and health risk behaviours in young people: systematic review and meta-analysis

Lancet

Long-term outcomes with biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomised superiority trial

Journal of Clinical Oncology

Five-Year Overall Survival Analysis of the JIPANG Study: Pemetrexed or Vinorelbine Plus Cisplatin for Resected Stage II-IIIA Nonsquamous Non–Small-Cell Lung Cancer

Hepatology

Duration of type 2 diabetes and liver-related events in nonalcoholic fatty liver disease: A landmark analysis

Clinical Gastroenterology

The Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease

Clinical Infectious Diseases

Prevalence of Comorbid Factors in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Randomized Trial of an Oral Microbiota–Based Therapeutic

Journal of infectious Diseases

Incidence of Cytomegalovirus Primary and Secondary Infection in Adolescent Girls: Results From a Prospective Study

Journal of Clinical Rheumatology

Hip Abductor Weakness and Its Association With New or Worsened Knee Pain: Data From the Multicenter Osteoarthritis Study

Efficacy and Safety of Sublingual Cyclobenzaprine for the Treatment of Fibromyalgia: Results From a Randomized, Double-Blind, Placebo-Controlled Trial

Arthritis and Rheumatology

A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

Circulation

Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial

American College of Cardiology

Stroke and Bleeding Risk in AF With CHA2DS2-VASc Score of One

Journals of the American College of Cardiology

Comparison of Intravascular Imaging, Functional, or Angiographically Guided Coronary Intervention

Journal of Clinical Endocrinology & Metabolism

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

Neurology:

Short-term Exposure to Air Pollution and Ischemic Stroke

A Systematic Review and Meta-analysis

Chest

Liberation From Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure

The American Journal of Respiratory and Critical Care Medicine

Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR

Clinical and Translational Gastroenterology

Proton Pump Inhibitor use and Complications of Cirrhosis Are Linked with Distinct Gut Microbial Bacteriophage and Eukaryotic Viral Like Particle Signatures in Cirrhosis

Clinical Gastroenterology AND Hepatology

Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study

Real-World Experience With Tofacitinib Dose De-Escalation in Patients With Moderate and Severe Ulcerative Colitis

Clinical Journal of Kidney International

Changes in Bone Quality after Treatment with Etelcalcetide

Comparison of Short-Term Outcomes in Kidney Transplant Recipients from SARS-CoV-2–Infected versus Noninfected Deceased Donors

Kidney International reports

Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

11 27 2023

Mon, 27 Nov 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing recently published articles.

New England Journal of Medicine

Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma

Journal of American Medical Association

Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial

Annals of Internal Medicine

Relationship Between Clinician Language and the Success of Behavioral Weight Loss Interventions

British Medical Journal

Blood cell differential count discretisation modelling to predict survival in adults reporting to the emergency room: a retrospective cohort study

Journal of Clinical Oncology

ROSEWOOD: A Phase II Randomized Study of Zanubrutinib Plus Obinutuzumab Versus Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma

Homoharringtonine-Based Induction Regimen Improved the Remission Rate and Survival Rate in Chinese Childhood AML: A Report From the CCLG-AML 2015 Protocol Study

Hepatology

Abdominal pain in patients with inflammatory bowel disease in remission

Clinical Gastroenterology AND Hepatology

Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis

Association Between the Presence of Metabolic Comorbidities and Liver-Related Events in Patients With Chronic Hepatitis B

Clinical Infectious Diseases

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections

Journal of infectious Diseases

Stability and Inactivation of Monkeypox Virus on Inanimate Surfaces

Journal of Clinical Rheumatology

How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects

Prevalence of Nonsteroidal Antiinflammatory Drugs Prescribed for Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies

Arthritis and Rheumatology

Large-Scale Analysis of Meniscus Morphology as Risk Factor for Knee Osteoarthritis

Risk–Benefit Analysis of Primary Prophylaxis Against Pneumocystis Jirovecii Pneumonia in Patients With Rheumatic Diseases Receiving Rituximab

Circulation October 24, 2023

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study

American College of Cardiology

Antithrombotic Regimens After Left Atrial Appendage Occlusion

Dapagliflozin in Patients With Heart Failure and Deterioration in Renal Function

Journal of Clinical Endocrinology & Metabolism

Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing's Disease

Neurology:

Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies

Chest

Microbiological Cure at Treatment Completion Is Associated With Longer Survival in Patients With Mycobacterium avium Complex Pulmonary Disease

The American Journal of Respiratory and Critical Care Medicine

Combination of BAL and Computed Tomography Differentiates Progressive and Non-progressive Fibrotic Lung Diseases

Clinical and Translational Gastroenterology

Real-Time Evaluation of Helicobacter pylori Infection by Convolution Neural Network During White-Light Endoscopy: A Prospective, Multicenter Study

Clinical Journal of American Society of Nephrology

Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN

Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study

Kidney International reports

Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes

11 20 2023

Mon, 20 Nov 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing recently published articles.

New England Journal of Medicine

First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion–Positive NSCLC

Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer

Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease

Arginine or Hypertonic Saline–Stimulated Copeptin to Diagnose AVP Deficiency

Journal of American Medical Association

Effect of Dietary Sodium on Blood PressureA Crossover Trial

Intravenous Vitamin C for Patients Hospitalized With COVID-19

Two Harmonized Randomized Clinical Trials

Multitarget Stool RNA Test for Colorectal Cancer Screening

Hypertension journal

Different Home Blood Pressure Thresholds to Predict Perfect 24-Hour Ambulatory Blood Pressure Control in Treated Hypertension Based on an “All-in-One” Device

Annals of Internal Medicine

Atezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial

Journal of Clinical Oncology

Zanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study

Hepatology

Microscopic colitis and risk of incident rheumatoid arthritis

Clinical Gastroenterology

The Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease

Clinical Infectious Diseases

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum

Journal of infectious Diseases

Hepatitis B e Antigen-Negative Single Hepatocyte Analysis Shows Transcriptional Silencing and Slow Decay of Infected Cells With Treatment

Journal of Clinical Rheumatology

Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review

Arthritis and Rheumatology

Association of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10-Year Magnetic Resonance Imaging Study

Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides During Rituximab Maintenance Therapy

Circulation October 24, 2023

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery

American College of Cardiology

SGLT2 Inhibitors for Cancer Therapy–Related Cardiac Dysfunction

Journal of Clinical Endocrinology & Metabolism

Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes

Neurology:

Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging

Chest

Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes

The American Journal of Respiratory and Critical Care Medicine

Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis

Clinical Gastroenterology AND Hepatology

Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study

The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure

Clinical Journal of American Society of Nephrology

Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait

Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

Kidney International reports

Randomized Study of Tenapanor Added to Phosphate Binders for Patients With Refractory Hyperphosphatemia

11 13 2023

Mon, 13 Nov 2023 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing recently published articles.

First we will be discussing articles in New England Journal of Medicine

Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis

Actionable Genotypes and Their Association with Life Span in Iceland

Trial of Botulinum Toxin for Isolated or Essential Head Tremor

Decolonization in Nursing Homes to Prevent Infection and Hospitalization

Nivolumab plus Gemcitabine–Cisplatin in Advanced Urothelial Carcinoma

Journal of American Medical Association

Automated Opt-Out vs Opt-In Patient Outreach Strategies for Breast Cancer Screening

Association of Gestational Diabetes With Subsequent Long-Term Risk of Mortality

Objective To investigate the associations between gestational diabetes and long-term risks of total and cause-specific mortality.

Annals of Internal Medicine

Relationship Between Clinician Language and the Success of Behavioral Weight Loss Interventions

Journal of Clinical Oncology

Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor–Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial

Hepatology

Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease

Clinical Gastroenterology AND Hepatology

Development and Validation of the Veterans Affairs Eosinophilic Esophagitis Cohort

Epidemiologic Burden and Projections for Eosinophilic Esophagitis–Associated Emergency Department Visits in the United States: 2009-2030

Journal of infectious Diseases

BK Polyomavirus Diversity After Hematopoietic Stem Cell Transplantation

Journal of Clinical Rheumatology

Development of American College of Rheumatology Quality Measures for Systemic Lupus Erythematosus: A Modified Delphi Process With Rheumatology Informatics System for Effectiveness (RISE) Registry Data Review

Examination of the Increased Risk for Falls Among Individuals With Knee Osteoarthritis: A Canadian Longitudinal Study on Aging Population-Based Study

Arthritis and Rheumatology

Baricitinib Improves Bone Properties and Biomechanics in Patients With Rheumatoid Arthritis: Results of the Prospective Interventional BARE BONE Trial

Circulation October 24, 2023

Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up

American College of Cardiology

Impact of Residual Inflammatory Risk in Patients Receiving Statin Therapy

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches - ISCHEMIA

Journal of Clinical Endocrinology & Metabolism

Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure

Neurology:

Movement Disorders in Patients With Genetic Developmental and Epileptic Encephalopathies

Chest

Clinic vs Home Spirometry for Monitoring Lung Function in Patients With Asthma

Background

The American Journal of Respiratory and Critical Care Medicine

Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators

Clinical Journal of American Society of Nephrology

Outcomes of Hospital-Acquired Hypernatremia

Fixed-Dose Combination Therapy for the Prevention of Cardiovascular Diseases in CKD: An Individual Participant Data Meta-Analysis

Kidney International reports

Supporting Patient-Centered Pregnancy Counseling in Nephrology Care: A Semistructured Interview Study of Patients and Nephrologists

11 6 2023

Mon, 06 Nov 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis

A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy

Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia

Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation

Perioperative Durvalumab for Resectable Non–Small-Cell Lung Cancer

Journal of Hypertension

Sedentary behavior and risk of cardiovascular disease and all-cause mortality in United States adults with hypertension

Hypertension journal

Blood Pressure and Cardiovascular Disease Mortality Among US Adults: A Sex-Stratified Analysis, 1999–2019

Journal of American Medical Association

Changes in Physician Electronic Health Record Use With the Expansion of Telemedicine

Management for Opioid Use Disorder Treatment

Annals of Internal Medicine

Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women

Suspected Bronchiectasis and Mortality in Adults With a History of Smoking Who Have Normal and Impaired Lung Function

Journal of Clinical Oncology

Trastuzumab Deruxtecan in Patients With HER2-Mutant Metastatic Non–Small-Cell Lung Cancer: Primary Results From the Randomized, Phase II DESTINY-Lung02 Trial

Hepatology

Effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy-confirmed nonalcoholic steatohepatitis

Clinical microbiology and Infection

To evaluate the safety and efficacy of switching from intravenous (IV) to oral antimicrobial therapy in patients with Enterobacterales bacteraemia, after completion of 3–5 days of microbiologically active IV therapy.

Journal of infectious Diseases

Sociodemographic Variables Can Guide Prioritized Testing Strategies for Epidemic Control in Resource-Limited Contexts

Arthritis and Rheumatology

Rheumatoid Arthritis–Specific Autoimmunity in the Lung Before and at the Onset of Disease

Clinical and Biomarker Responses to BI 655064, an Antagonistic Anti-CD40 Antibody, in Patients With Active Lupus Nephritis: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial

Circulation October 24, 2023

Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III

American College of Cardiology

Lead Extraction and Mortality Among Patients With CIED Infection

China Tongxinluo Study for Myocardial Protection in Patients With Acute Myocardial Infarction

Relationship of Daily Step Counts to All-Cause Mortality and Cardiovascular Events

Clinical Endocrinology & Metabolism

Thyroid Function Tests in Children and Adolescents With Trisomy 21: Definition of Syndrome-Specific Reference Ranges

BLOOD ADVANCES

JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study

The American Journal of Respiratory and Critical Care Medicine

Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older – The RECOVER Trial

Incorporating Effects of Time Accrued on the Waiting List into Lung Transplantation Survival Models

INTENSIVE CARE MEDICINE

Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial

JOURNAL OF AMERICAN SOCIETY OF MEDICINE, SURGERY

Primary Care Physician Follow-Up and 30-Day Readmission After Emergency General Surgery Admissions

Urology Journal

Acute Kidney Injury Within 90Days of Radical Cystectomy for Bladder Cancer: Incidence and Risk Factors

10 30 2023

Mon, 30 Oct 2023 11:00:00 +0000

Hi, This Week in Medicine, we will be discussing

NEJM

Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis

Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes

Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis

Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

JAMA

Pharmacy e-Prescription Dispensing Before and After CancelRx Implementation

Defining Usual Oral Temperature Ranges in Outpatients Using an Unsupervised Learning Algorithm

Cardiac Arrest Survival at Emergency Medical Service Agencies in Catchment Areas With Primarily Black and Hispanic Populations

Annals of Internal Medicine

Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis

Lancet

Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trials

Journal of Clinical Oncology

Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study

Clinical Gastroenterology

Blood Test Increases Colorectal Cancer Screening in Persons Who Declined Colonoscopy and Fecal Immunochemical Test

Hepatology

Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study

Clinical Infectious Diseases

Sustained Viral Suppression With Dolutegravir Monotherapy Over 192 Weeks in Patients Starting Combination Antiretroviral Therapy During Primary Human Immunodeficiency Virus Infection (EARLY-SIMPLIFIED): A Randomized, Controlled, Multi-site, Noninferiority Trial

Journal of infectious Diseases

Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in Journal of Clinical Rheumatology

Clinical Characteristics and Prognostic Value of Ro52/SSA Antibodies in Idiopathic Inflammatory Myopathies

Arthritis and Rheumatology

Bone Loss in Inflammatory Rheumatic Musculoskeletal Disease Patients Treated With Low-Dose Glucocorticoids and Prevention by Anti-Osteoporosis Medications

Circulation

Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest

ACC Latest-in-Cardiology

Performance of the ACC/AHA Pooled Cohort Cardiovascular Risk Equations in Clinical Practice |

Journal of Clinical Endocrinology & Metabolism

Heart Rate Variability and Incident Type 2 Diabetes in General Population

New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study

Neurology:

Randomized Trial Comparing Low- vs High-Dose IV Dexamethasone for Patients With Moderate to Severe Migraine

Chest

The Effect of Inhaled Corticosteroids on Pneumonia Risk in Patients With COPD-Bronchiectasis Overlap

Lifestyle, Genetic Susceptibility, and the Risk of Idiopathic Pulmonary Fibrosis

Cell-Free DNA Fragmentomes in the Diagnostic Evaluation of Patients With Symptoms Suggestive of Lung Cancer

The American Journal of Respiratory and Critical Care Medicine

Sleep Apnea Physiological Burdens and Cardiovascular Morbidity and Mortality

Clinical Journal of American Society of Nephrology

Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy

Kidney International

Implications of Complete Proteinuria Remission at any Time in Focal Segmental Glomerulosclerosis: Sparsentan DUET Trial

10 23 2023

Mon, 23 Oct 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

NEJM

Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer

Optical Coherence Tomography–Guided versus Angiography-Guided PCI

OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions

Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty

JAMA

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection

The ACORN Randomized Clinical Trial

Endovascular Aneurysm Repair Devices as a Use Case for Postmarketing Surveillance of Medical Devices

Changes in the Use of Long-Term Medications Following Incident Dementia Diagnosis

Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched ComparatorsA 2-Year Cohort Analysis

Annals of Internal Medicine

Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events

Atrial Fibrillation Recurrence in Patients With Transient New-Onset Atrial Fibrillation Detected During Hospitalization for Noncardiac Surgery or Medical Illness

Lancet

Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study

Journal of Clinical Oncology

Cluster Randomized Pragmatic Clinical Trial Testing Behavioral Economic Implementation Strategies to Improve Tobacco Treatment for Patients With Cancer Who Smoke

Hepatology

Predicting liver-related events in NAFLD: A predictive model

Clinical Infectious Diseases

Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir

Journal of infectious Diseases

Bronchiolitis, Regardless of Its Etiology and Severity, Is Associated With Increased Risk of Asthma: A Population-Based Study

Journal of Clinical Rheumatology

Does the Type of Failure and the Choice of the Second Biologic Influence Response and Persistence on Medication in Rheumatoid Arthritis?

Arthritis and Rheumatology

The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome

Circulation

Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus

ACC: LATEST IN CARDIOLOGY

Benefits and Drawbacks of Vegetarian and Vegan Diets: Key Points

Journal of Clinical Endocrinology & Metabolism

Visit to Visit Hemoglobin A1c Variation and Long-term Risk of Major Adverse Limb Events in Patients With Type 2 Diabetes

Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women: The ADIMOS Case-Control Study

Neurology:

Association Between Socioeconomic Factors, Race, and Use of a Specialty Memory Clinic

Chest

Effect of Hypertonic Saline on Lung Function as Add-on Treatment in People With Cystic Fibrosis Receiving Dornase Alfa

Noninvasive Oxygenation Strategies in Adult Patients With Acute Hypoxemic Respiratory Failure

Observation, Aspiration, or Tube Thoracostomy for Primary Spontaneous Pneumothorax

The American Journal of Respiratory and Critical Care Medicine

A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities

Clinical Journal of American Society of Nephrology

Early Risk Stratification for Natural Disease Course in Fabry Patients Using Plasma Globotriaosylsphingosine Levels

Kidney International

Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment

10 16 2023

Mon, 16 Oct 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

NEJM

Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction

Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia

JAMA

Effects of Cuff Size on the Accuracy of Blood Pressure ReadingsThe Cuff(SZ) Randomized Crossover Trial

Association of Intensive Lifestyle Intervention for Type 2 Diabetes With Labor Market Outcomes

Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US

Annals of Internal Medicine

Risk for Congenital Anomalies in Children Conceived With Medically Assisted Fertility Treatment

Implications of the Use of Artificial Intelligence Predictive Models in Health Care Settings

BMJ

Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities

Lancet

Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial

Journal of Clinical Oncology

Eltrombopag for Low-Risk Myelodysplastic Syndromes With Thrombocytopenia: Interim Results of a Phase II, Randomized, Placebo-Controlled Clinical Trial (EQOL-MDS)

Hepatology

Lactulose therapy for patients with cirrhosis, portal hypertension, and poor patient-reported outcomes: The Mi-Kristal trial

Blood

Prevalence and significance of DDX41 gene variants in the general population

Clinical Infectious Diseases

Current Epidemiology and Clinical Features of Cryptococcus Infection in Patients Without Human Immunodeficiency Virus

Journal of infectious Diseases

JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain

Journal of Clinical Rheumatology

The Effect of Clinical and Genetic Variables of Familial Mediterranean Fever Patients: Real Life Data

Arthritis and Rheumatology

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease

Circulation

Cost-Effectiveness of Vericiguat in Patients With Heart Failure With Reduced Ejection Fraction: The VICTORIA Randomized Clinical Trial

American college of cardiology: /Latest-in-Cardiology

Machine Learning Approaches in Primary Mitral Regurgitation

Journal of Clinical Endocrinology & Metabolism

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study

Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity

Neurology:

Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort

Chest

Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease

Lower vs Higher Fluid Volumes in Adult Patients With Sepsis

The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism

The American Journal of Respiratory and Critical Care Medicine

Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial

Clinical and Translational Gastroenterology

Lactulose versus polyethylene glycol for bowel preparation: a single-center, prospective, randomized controlled study based on the BMI

Clinical Journal of American Society of Nephrology

Renin–Angiotensin–Aldosterone System Blockade after AKI with or without Recovery among US Veterans with Diabetic Kidney Disease

Kidney International

A cohort study found a high risk of end-stage kidney disease associated with acromegaly

10 9 2023

Mon, 09 Oct 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing recently published articles in Medical journals.

NEJM

Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper

Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression

JAMA

Effects of Cuff Size on the Accuracy of Blood Pressure ReadingsThe Cuff(SZ) Randomized Crossover Trial

Changes in the Use of Long-Term Medications Following Incident Dementia Diagnosis

Defining Usual Oral Temperature Ranges in Outpatients Using an Unsupervised Learning Algorithm

Annals of Internal Medicine

Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis

Suspected Bronchiectasis and Mortality in Adults With a History of Smoking Who Have Normal and Impaired Lung Function

Nature Medicine

Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial

BMJ

Mortality risks associated with floods in 761 communities worldwide: time series study

Lancet

Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study

Journal of Clinical Oncology

Phase II Trial of Atezolizumab Combined With Carboplatin and Pemetrexed for Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer With Untreated Brain Metastases

Hepatology

Etiological cure prevents further decompensation and mortality in patients with cirrhosis with ascites as the single first decompensating event

Blood

Real-world experience of CAR T-cell therapy in older patients with relapsed/refractory diffuse large B-cell lymphoma

Clinical Infectious Diseases

One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial

Journal of infectious Diseases

Epidemiology and Risk Factors of Norovirus Infections Among Diarrhea Patients Admitted to Tertiary Care Hospitals in Bangladesh

Journal of Clinical Rheumatology

Pan American League of Associations for Rheumatology Guidelines for the Treatment of Takayasu Arteritis

Arthritis and Rheumatology

The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria

Circulation

Changes in Cardiovascular Spending, Care Utilization, and Clinical Outcomes Associated With Participation in Bundled Payments for Care Improvement – Advanced

ACC

Home-Based Walking and Supervised Treadmill Exercise in PAD

Journal of Clinical Endocrinology & Metabolism

Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark—A National Observational Study

Gram-Negative Bacteria and Lipopolysaccharides as Risk Factors for the Occurrence of Diabetic Foot

Neurology:

Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease:

Chest

Redefining the Role of Bronchoscopy in the Workup of Severe Uncontrolled Asthma in the Era of Biologics

Emulating Target Trials Comparing Early and Delayed Intubation Strategies

Effectiveness of Flexible Bronchoscopy Simulation-Based Training

The American Journal of Respiratory and Critical Care Medicine

Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life

Clinical Journal of American Society of Nephrology

Research and Nonresearch Industry Payments to Nephrologists in the United States between 2014 and 2021

10 2 2023

Mon, 02 Oct 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

NEJM

Ferric Carboxymaltose in Heart Failure with Iron Deficiency

JAMA

Comparison of Hospital Online Price and Telephone Price for Shoppable Services

Annals of Internal Medicine

Role of Artificial Intelligence in Colonoscopy Detection of Advanced Neoplasias

Nature Medicine

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

BMJ

Preconception contraceptive use and miscarriage: prospective cohort study

Lancet

Sex-related differences in functional capacity and its implications in risk stratification before major non-cardiac surgery

Journal of Clinical Oncology

Bladder-Sparing Treatment With Radical Dose Radiotherapy Is an Effective Alternative to Radical Cystectomy in Patients With Clinically Node-Positive Nonmetastatic Bladder Cancer

Clinical Infectious Diseases

Cholesterol Contributes to Risk, Severity, and Machine Learning-Driven Diagnosis of Lyme Disease

Journal of infectious Diseases

Impact of HCV Testing and Treatment on HCV Transmission Among Men Who Have Sex With Men and Who Inject Drugs in San Francisco: A Modelling Analysis

Journal of Clinical Rheumatology

Patterns of Involvement of the Hand Joints in Classical Rheumatoid Arthritis

Circulation

Biodegradable-Polymer or Durable-Polymer Stents in Patients at High Bleeding Risk: A Randomized, Open-Label Clinical Trial

ACC Latest in Cardiology

LDL-C Reduction With Lipid-Lowering Therapy for Primary Prevention of Major Vascular Events Among Older Individuals

Journal of Clinical Endocrinology & Metabolism

The Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes

Clinical Journal of Nephrology

Discrepancies between Cystatin C–Based and Creatinine-Based eGFR

Kidney international reports

Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on Vascular

9 25 2023

Mon, 25 Sep 2023 10:00:00 +0000

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity

Inhaled Fluticasone Furoate for Outpatient Treatment of Covid-19

Trial of Solanezumab in Preclinical Alzheimer’s Disease

JAMA

Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants

Follow-Up of the OPTIMIST-A Randomized Clinical Trial

Annals of Internal Medicine

Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery

A Nationwide Cohort Study

The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis: Individual Patient Data From Five Randomized Trials

Nature Medicine

Longitudinal genomic surveillance of carriage and transmission of Clostridioides difficile in an intensive care unit

British Medical Journal

Sensitivity, specificity, and diagnostic accuracy of WHO 2013 criteria for diagnosis of gestational diabetes mellitus in low risk early pregnancies: international, prospective, multicentre cohort study

Preconception contraceptive use and miscarriage: prospective cohort study

Objectives To evaluate the association between preconception contraceptive use and miscarriage.

Lancet

Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis

Clinical Infectious Diseases

Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus

Journal of infectious Diseases

Bacterial Vaginosis and Spontaneous Clearance of Chlamydia trachomatis in the Longitudinal Study of Vaginal Flora

Journal of Clinical Rheumatology

Disease-Modifying Antirheumatic Drug Use and Its Effect on Long-term Opioid Use in Patients With Rheumatoid Arthritis

Circulation

Early Ablation for Atrial Fibrillation After Admission for Heart Failure

Effect of Semaglutide 2.4 mg Once Weekly on Function and Symptoms in Subjects With Obesity-Related Heart FailureWith Preserved Ejection Fraction - STEP-HFpEF

American Journal of Respiratory and Critical Care Medicine

FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease

Mortality in Patients with Obesity and Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation: The Multicenter ECMObesity Study

Journal of Clinical Endocrinology & Metabolism

Efficacy and Safety of Low-dose Spironolactone for Chronic Kidney Disease in Type 2 Diabetes

Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia

American journal of hypertension

Intensive Blood Pressure Control and Cardiovascular Outcomes in Elderly Patients: A Secondary Analysis of SPRINT Study Based on a 60-Year Age Cutoff

September 21 ,2023

Thu, 21 Sep 2023 23:31:49 +0000

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity

Inhaled Fluticasone Furoate for Outpatient Treatment of Covid-19

Trial of Solanezumab in Preclinical Alzheimer’s Disease

The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis: Individual Patient Data From Five Randomized Trials

Association between physical therapy frequency and postacute care for a national cohort of patients hospitalized with pneumonia

Cancer Screening in the United States During the Second Year of the COVID-19 Pandemic

Albuterol-Budesonide Pressurized Metered Dose Inhaler in Patients With Mild-to-Moderate Asthma